Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure
Public ClinicalTrials.gov record NCT01910389. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is a multi-center, prospective, randomized, double blind, placebo-controlled clinical trial. Subjects in the study will be adults with New York Heart Association (NYHA) Class II-IV heart failure (HF) due to left ventricular systolic dysfunction (LVSD), left ventricular ejection fraction (LVEF) \<0.40, and secondary pulmonary hypertension (PH). The purpose of the study is to evaluate the safety, effectiveness, and effects of tadalafil compared to placebo on the subjects' functional capacity / quality of life.
Study identification
- NCT ID
- NCT01910389
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 23 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 21 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2013 (Type not available)
- Primary completion
- Feb 2014 (Actual)
- Completion
- Feb 2014 (Actual)
- Last update posted
- May 4, 2015
2013 – 2014
United States locations
- U.S. sites
- 62
- U.S. states
- 26
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Inc - Research | Huntsville | Alabama | — | — |
| Baptist Health Transplant Institute | Little Rock | Arkansas | — | — |
| Allianz Medical and Research Center | Fountain Valley | California | — | — |
| Christiana Care Health System | Newark | Delaware | — | — |
| Broward Health | Fort Lauderdale | Florida | — | — |
| Miller School of Medicine University of Miami | Miami | Florida | — | — |
| Orlando Health | Orlando | Florida | — | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | — | — |
| Brevard Cardiovascular Research Associates | Rockledge | Florida | — | — |
| University Cardiology Associates LLC | Augusta | Georgia | — | — |
| Eisenhower Army Medical Center | Fort Gordon | Georgia | — | — |
| Northwestern University | Chicago | Illinois | — | — |
| University of Illinois Hospital | Chicago | Illinois | — | — |
| Methodist Medical Group Cardiology | Peoria | Illinois | — | — |
| Baptist Hospital East | Louisville | Kentucky | — | — |
| Research Integrity LLC | Owensboro | Kentucky | — | — |
| LSU Health Sciences Center | New Orleans | Louisiana | — | — |
| Maine Research Associates | Auburn | Maine | — | — |
| Johns Hopkins Hospital | Baltimore | Maryland | — | — |
| Primary Care Cardiology Research, Inc. | Ayer | Massachusetts | — | — |
| Brigham and Women's Hospital | Boston | Massachusetts | — | — |
| Massachusetts General Hospital | Boston | Massachusetts | — | — |
| MGH West | Waltham | Massachusetts | — | — |
| University of Michigan Health System | Ann Arbor | Michigan | — | — |
| Oakwood Hospital and Medical Center | Dearborn | Michigan | — | — |
| Henry Ford Hospital | Detroit | Michigan | — | — |
| William Beaumont Hospital | Royal Oak | Michigan | — | — |
| Covenant Center for the Heart | Saginaw | Michigan | — | — |
| Essentia Health East | Duluth | Minnesota | — | — |
| Metropolitan Heart and Vascular Institute | Minneapolis | Minnesota | — | — |
| Mayo Clinic | Rochester | Minnesota | — | — |
| Missouri Cardiovascular Specialists | Columbia | Missouri | — | — |
| St. Luke's Health System | Kansas City | Missouri | — | — |
| Glacier View Research Institute | Kalispell | Montana | — | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | — | — |
| Hackensack University Medical Center | Hackensack | New Jersey | — | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | — | — |
| Heart & Vascular Center of NJ/Cardio Metabolic Institute | Somerset | New Jersey | — | — |
| New York Methodist Hospital | Brooklyn | New York | — | — |
| Columbia University Medical Center | New York | New York | — | — |
| Mount Sinai Medical Center | New York | New York | — | — |
| Cardiology Associates of Schenectady | Schenectady | New York | — | — |
| Stony Brook University Hospital | Stony Brook | New York | — | — |
| SUNY Upstate Medical University | Syracuse | New York | — | — |
| Bronx - Lebanon Hospital Center | The Bronx | New York | — | — |
| LeBauer Cardiovascular Research Foundation | Greensboro | North Carolina | — | — |
| The Lindner Center for Research & Education at The Christ Hospital | Cincinnati | Ohio | — | — |
| Cleveland Clinic | Cleveland | Ohio | — | — |
| Dayton VA Medical Center | Dayton | Ohio | — | — |
| Oklahoma City VA | Oklahoma City | Oklahoma | — | — |
| Warren Cancer Research Foundation | Tulsa | Oklahoma | — | — |
| Lancaster Heart and Stroke Foundation | Lancaster | Pennsylvania | — | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | — | — |
| Temple University | Philadelphia | Pennsylvania | — | — |
| Grand View - Lehigh Valley Health Service | Sellersville | Pennsylvania | — | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | — | — |
| Stern Cardiovascular Foundation, Inc. | Germantown | Tennessee | — | — |
| CIVA/CArdiovascular Research Institute of Dallas | Dallas | Texas | — | — |
| Michael E. Debakey VA Medical Center | Houston | Texas | — | — |
| University of Utah | Salt Lake City | Utah | — | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | — | — |
| Aspirus Wausau Hospital | Wausau | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01910389, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2015 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01910389 live on ClinicalTrials.gov.