A New Approach to Measuring Energy Expenditure in Humans
Public ClinicalTrials.gov record NCT01938794. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Improvements to the Doubly Labeled Water Technique to Measure Total Daily Energy Expenditure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Accurately measuring how many calories a person burns each day is difficult to do. Researchers can do this with a technique called doubly labeled water (DLW). This involves drinking water that is "labeled" with a non-radioactive tracer. After a few hours, the labeled water can be detected in the urine. To measure how many calories are burned (Total daily energy expenditure, TDEE), urine samples are collected several days apart. Although this technique is accurate, it is also challenging for two reasons. First, the labeled water is expensive. Second, the urine samples are analyzed using equipment (Isotope Ratio Mass Spectrometer, or IRMS) that is expensive and difficult to operate. The goal of this project is to develop a new instrument to perform DLW measurements of TDEE. This instrument, called a triple isotope water analyzer (TIWA) is less expensive and easier to operate than IRMS. Additionally, since the TIWA is more accurate than IRMS, it may potentially reduce the amount of labeled water required to measure TDEE, and thus reduce costs. The purpose of this study is to compare the accuracy of measuring TDEE from labeled water using the new instrument (TIWA) and from the traditional approach (IRMS). We will also compare the accuracy to the measurement of TDEE from whole-room indirect calorimetry (metabolic room), which is considered the most accurate way to measure TDEE.
Study identification
- NCT ID
- NCT01938794
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 72 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2013
- Primary completion
- Aug 30, 2017
- Completion
- Dec 30, 2017
- Last update posted
- Oct 8, 2019
2013 – 2017
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01938794, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2019 · Synced Sep 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01938794 live on ClinicalTrials.gov.