Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Negative for Hepatitis B e Antigen
Public ClinicalTrials.gov record NCT01940341. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Tenofovir Alafenamide (TAF) 25 mg QD Versus Tenofovir Disoproxil Fumarate (TDF) 300 mg QD for the Treatment of HBeAg-Negative, Chronic Hepatitis B
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to compare the efficacy, safety, and tolerability of tenofovir alafenamide (TAF) versus tenofovir disoproxil fumarate (TDF) in treatment-naive and treatment-experienced adults with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV) infection.
Study identification
- NCT ID
- NCT01940341
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 426 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 12, 2013 (Actual)
- Primary completion
- Sep 30, 2015 (Actual)
- Completion
- Aug 31, 2022 (Actual)
- Last update posted
- Sep 25, 2023
2013 – 2022
United States locations
- U.S. sites
- 14
- U.S. states
- 8
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Asian Pacific Liver Center | Los Angeles | California | 90020 | — |
| Stanford University Medical Center | Palo Alto | California | 94304 | — |
| Huntington Medical Research Institutes | Pasadena | California | 91105 | — |
| Research and Education, Inc. | San Diego | California | 92105 | — |
| University California San Francisco (UCSF) | San Francisco | California | 94110 | — |
| Silicon Valley Research Institute | San Jose | California | 95128 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Digestive Disease Associates, PA | Catonsville | Maryland | 21228 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| ID Care | Hillsborough | New Jersey | 08844 | — |
| Sing Chan Private Practice | Flushing | New York | 11354 | — |
| New Discovery, LLC | Flushing | New York | 11355 | — |
| Xiaoli Ma, PC | Philadelphia | Pennsylvania | 19107 | — |
| Hunter Holmes McGuire VA DVMC | Richmond | Virginia | 23249 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01940341, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2023 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01940341 live on ClinicalTrials.gov.