Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Positive for Hepatitis B e Antigen
Public ClinicalTrials.gov record NCT01940471. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Tenofovir Alafenamide (TAF) 25 mg QD Versus Tenofovir Disoproxil Fumarate (TDF) 300 mg QD for the Treatment of HBeAg-Positive, Chronic Hepatitis B
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to compare the efficacy, safety, and tolerability of tenofovir alafenamide (TAF) versus tenofovir disoproxil fumarate (TDF) in treatment-naive and treatment-experienced adults with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection.
Study identification
- NCT ID
- NCT01940471
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 875 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2013 (Actual)
- Primary completion
- Nov 16, 2015 (Actual)
- Completion
- Oct 13, 2022 (Actual)
- Last update posted
- Oct 10, 2023
2013 – 2022
United States locations
- U.S. sites
- 15
- U.S. states
- 8
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Coalition of Inclusive Medicine | Los Angeles | California | 90020 | — |
| Stanford University Medical Center | Palo Alto | California | 94304 | — |
| Huntington Medical Research Institutes | Pasadena | California | 91105 | — |
| Research and Education, Inc. | San Diego | California | 92105 | — |
| Silicon Valley Research Institute | San Jose | California | 95128 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Digestive Disease Associates, PA | Catonsville | Maryland | 21228 | — |
| Tufts Medical Center, Inc | Boston | Massachusetts | 02111 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Sing Chan Private Practice | Flushing | New York | 11354 | — |
| New Discovery, LLC | Flushing | New York | 11355 | — |
| Jefferson Medical College | Philadelphia | Pennsylvania | 19107 | — |
| Xiaoli Ma, PC | Philadelphia | Pennsylvania | 19107 | — |
| Texas Clinical Research Institute, LLC | Arlington | Texas | 76012 | — |
| Kelsey Research Foundation | Houston | Texas | 77005 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 145 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01940471, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 10, 2023 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01940471 live on ClinicalTrials.gov.