ClinicalTrials.gov record
A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study)
ClinicalTrials.gov ID: NCT01945775
Public ClinicalTrials.gov record NCT01945775. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, OPEN-LABEL, RANDOMIZED PARALLEL,2-ARM,MULTI-CENTER STUDY OF TALAZOPARIB(BMN 673) VERSUS PHYSICIAN'S CHOICE IN GERMLINE BRCA MUTATION SUBJECTS WITH LOCALLY ADVANCED AND/OR METASTATIC BREAST CANCER, WHO HAVE RECEIVED PRIOR CHEMOTHERAPY REGIMENS FOR METASTATIC DISEASE
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this open-label, 2:1 randomized phase III trial is to compare the safety and efficacy of talazoparib (also known as BMN 673) versus protocol-specific physician's choice in patients who have locally advanced and/or metastatic breast cancer with germline BRCA mutations.
Study identification
- NCT ID
- NCT01945775
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 431 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 14, 2013 (Actual)
- Primary completion
- Sep 15, 2017 (Actual)
- Completion
- Mar 5, 2021 (Actual)
- Last update posted
- Jan 20, 2022
2013 – 2021
United States locations
- U.S. sites
- 207
- U.S. states
- 23
- U.S. cities
- 139
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates P.C. - NAHOA | Flagstaff | Arizona | 86001 | — |
| HonorHealth | Scottsdale | Arizona | 85258 | — |
| Virginia G. Piper Cancer Pharmacy | Scottsdale | Arizona | 85258 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Antioch | California | 94509 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Antioch | California | 94531 | — |
| CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Fairfield | California | 94533-6901 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Gilroy | California | 95020 | — |
| Los Angeles Hematology Oncology Medical Group | Glendale | California | 91204 | — |
| Los Angeles Hematology Oncology Medical Group | Glendale | California | 91206 | — |
| Marin Specialty Care | Greenbrae | California | 94904 | — |
| Los Angeles Hematology Oncolgy Medical Group | Los Angeles | California | 90017 | — |
| Los Angeles Hematology Oncology Medical Group | Los Angeles | California | 90057 | — |
| Drug Management Only: UCLA West Medical Pharmacy, Attn:Steven L. Wong, Pharm.D. | Los Angeles | California | 90095-7349 | — |
| Drug Management only: UCLA West Medical Pharmacy | Los Angeles | California | 90095-7349 | — |
| UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm. D. | Los Angeles | California | 90095-7349 | — |
| UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D. | Los Angeles | California | 90095-7349 | — |
| UCLA West Medical Pharmacy, Attn: Steven L. Wong | Los Angeles | California | 90095-7349 | — |
| UCLA West Medical Pharmacy, Attn:Steven L. Wong, Pharm.D. | Los Angeles | California | 90095-7349 | — |
| Regulatory Managment Only: TRIO-US Central Administration | Los Angeles | California | 90095 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| TRIO-US Central Administration | Los Angeles | California | 90095 | — |
| UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D. | Los Angeles | California | 90095 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Martinez | California | 94553 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Milpitas | California | 95035-5491 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Modesto | California | 95356 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Mountain View | California | 94041 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Napa | California | 94558-3313 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | Oakland | California | 94611 | — |
| Kaiser Permanente Medical Center (Radiology) | Oakland | California | 94611 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Pleasanton | California | 94558 | — |
| Torrance Health Association, DBA Torrance Memorial Physician Network/Cancer care Associates | Redondo Beach | California | 90277 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | Redwood City | California | 94063 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | Roseville | California | 95661 | — |
| Southern California Permanente Medical Group | San Diego | California | 92120 | — |
| UCSF - Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| UCSF Helen Diller Comprehensive Cancer Centre - Precision Cancer Medicine Building | San Francisco | California | 94158 | — |
| Kaiser Permanente Mission Bay Medical Center Lab Drawing Station | San Francisco | California | 94518 | — |
| Kaiser Permanente Medical Center Lab Drawing Station | San Jose | California | 95110 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | San Leandro | California | 94577 | — |
| Pacific Central Coast Health Centers - San Luis Obispo Oncology and Hematology Health Center | San Luis Obispo | California | 93401 | — |
| Ridley Tree Cancer Center | Santa Barbara | California | 93105 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93105 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | Santa Clara | California | 95051 | — |
| Central Coast Medical Oncology Corporation | Santa Maria | California | 93454 | — |
| UCLA Hematology Oncology | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology - Parkside | Santa Monica | California | 90404 | — |
| UCLA Santa Monica Medical Center & Orthopaedic Hospital | Santa Monica | California | 90404 | — |
| Sutter North Bay Health Plaza | Santa Rosa | California | 95403 | — |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | — |
| Sutter Santa Rosa Regional Hospital | Santa Rosa | California | 95403 | — |
| Ridley Tree Cancer Center | Solvang | California | 93463 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | South San Francisco | California | 94080 | — |
| Stanford Cancer Institute | Stanford | California | 94305 | — |
| Stanford Women's Cancer Center | Stanford | California | 94305 | — |
| UCLA Hematology/Oncology - Santa Clarita | Valencia | California | 91355 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | Vallejo | California | 94589 | — |
| Kaiser Permanente Medical Center (clinic+DSL) | Walnut Creek | California | 94596 | — |
| Southern California Permanente Medical Group | Woodland Hills | California | 91367 | — |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers | Littleton | Colorado | 80120-4413 | — |
| Rocky Mountain Cancer Centers | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers | Longmont | Colorado | 80501 | — |
| Rocky Mountain Cancer Centers | Parker | Colorado | 80138 | — |
| Rocky Mountain Cancer Centers | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers | Thornton | Colorado | 80260 | — |
| Cancer Center of Central Connecticut | Plainville | Connecticut | 06062 | — |
| Florida Cancer Specialists | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | — |
| Sylvester Comprehensive Cancer Center Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Florida Cancer Specialists | Hudson | Florida | 34667 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32003 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32204 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32207 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32258 | — |
| Cancer Specialists of North Florida | Jacksonville Beach | Florida | 32250 | — |
| Florida Cancer Specialists | Lady Lake | Florida | 32159 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialists | Lecanto | Florida | 34461 | — |
| "University of Miami Hospital & Clinics,Sylvester Comprehensive Cancer Center/UMHC" | Miami | Florida | 33136 | — |
| Sylvester Comprehensive Cancer Center Kendall | Miami | Florida | 33176 | — |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | — |
| Florida Cancer Specialists | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | Orlando | Florida | 32806 | — |
| Orlando Health, Inc | Orlando | Florida | 32806 | — |
| Sylvester Comprehensive Cancer Center Plantation | Plantation | Florida | 33324 | — |
| Cancer Specialists of North Florida | Saint Augustine | Florida | 32086 | — |
| Florida Cancer Specialists | Spring Hill | Florida | 34608 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists | Tavares | Florida | 32778 | — |
| Central Georgia Cancer Care, PC | Macon | Georgia | 31201 | — |
| Central Georgia Cancer Care, PC | Warner Robins | Georgia | 31088-2259 | — |
| Indiana University- Melvin and Bren Simon Cancer Center (IUSCC) | Indianapolis | Indiana | 46202 | — |
| IU Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | 46202 | — |
| Springmill Medical Clinic | Indianapolis | Indiana | 46290 | — |
| The University of Kansas Cancer Center (Regulatory Office) | Fairway | Kansas | 66205 | — |
| The University of Kansas Cancer Center | Kansas City | Kansas | 66112 | — |
| The University of Kansas Cancer Center | Overland Park | Kansas | 66210 | — |
| The University of Kansas Cancer Center - Investigational Drug Services | Westwood | Kansas | 66205 | — |
| University of Maryland, Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | — |
| Cancer And Hematology Centers Of Western Michigan | Grand Rapids | Michigan | 49506 | — |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology, P.A. | Edina | Minnesota | 55435-2150 | — |
| Minnesota Oncology Hematology, P.A. | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology, P.A. | Maplewood | Minnesota | 55109 | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Minnesota Oncology Hematology, P.A. | Saint Paul | Minnesota | 55102-2389 | — |
| Minnesota Oncology Hematology, P.A. | Woodbury | Minnesota | 55125 | — |
| The West Clinic, P.C. | Corinth | Mississippi | 38834 | — |
| The West Clinic, P.C. d/b/a West Cancer Center | Southaven | Mississippi | 38671 | — |
| The University of Kansas Cancer Center | Kansas City | Missouri | 64131 | — |
| The University of Kansas Cancer Center | Kansas City | Missouri | 64154 | — |
| The University of Kansas Cancer Center | Lee's Summit | Missouri | 64064 | — |
| Comprehensive Cancer Centers Of Nevada | Henderson | Nevada | 89052 | — |
| New York Oncology Hematology, P.C. | Albany | New York | 12208 | — |
| New York Oncology Hematology, P.C. | Clifton Park | New York | 12065 | — |
| New York University Langone Medical Center | New York | New York | 10016 | — |
| Perlmutter Cancer Center | New York | New York | 10016 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10021 | — |
| Weill Cornell Medical College - New York-Presbyterian Hospital | New York | New York | 10021 | — |
| New York-Presbyterian Hospital/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Weill Cornell Breast Center | New York | New York | 10065 | — |
| Weill Cornell Medical Center | New York | New York | 10065 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10065 | — |
| Eastchester Center for Cancer Care | The Bronx | New York | 10469 | — |
| Hope Women's Cancer Centers | Asheville | North Carolina | 28806 | — |
| MH Mission Hospital, LLLP | Asheville | North Carolina | 28806 | — |
| Novant Health Cancer Specialists | Charlotte | North Carolina | 28204 | — |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Southern Oncology Specialists | Charlotte | North Carolina | 28262 | — |
| Lake Norman Hematology Oncology Specialists | Huntersville | North Carolina | 28078 | — |
| Novant Health Huntersville Medical Center | Huntersville | North Carolina | 28078 | — |
| Southern Oncology Specialists | Huntersville | North Carolina | 28078 | — |
| Novant Health Cancer Specialists | Matthews | North Carolina | 28105 | — |
| Novant Health Matthews Medical Center | Matthews | North Carolina | 28105 | — |
| Lake Norman Hematology Oncology Specialists | Mooresville | North Carolina | 28117 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97213 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | — |
| Northwest Cancer Specialists, P.C. | Tigard | Oregon | 97223 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Medical Center, William M. Cooper Pavilion, Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Tennessee Oncology, PLLC | Dickson | Tennessee | 37055 | — |
| Tennessee Oncology, PLLC | Franklin | Tennessee | 37067 | — |
| Tennessee Oncology PLLC | Gallatin | Tennessee | 37066 | — |
| The West Clinic, P.C. d/b/a West Cancer Center | Germantown | Tennessee | 38138 | — |
| Tennessee Oncology, PLLC | Hermitage | Tennessee | 37076 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Tennessee Oncology, PLLC | Lebanon | Tennessee | 37090 | — |
| The West Clinic, P.C. d/b/a West Cancer Center | Memphis | Tennessee | 38104 | — |
| Tennessee Oncology PLLC | Murfreesboro | Tennessee | 37129 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37205 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37207 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37211 | — |
| Tennessee Oncology, PLLC | Shelbyville | Tennessee | 37160 | — |
| Tennessee Oncology PLLC | Smyrna | Tennessee | 37167 | — |
| The Center for Cancer and Blood Disorders | Arlington | Texas | 76014 | — |
| Texas Oncology-South Austin | Austin | Texas | 78745 | — |
| The Center for Cancer and Blood Disorders (Huguley) | Burleson | Texas | 76028 | — |
| Texas Oncology - Cedar Park | Cedar Park | Texas | 78613 | — |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Texas Oncology-El Paso Cancer Treatment Center Grandview | El Paso | Texas | 79902 | — |
| Texas Oncology-El Paso Cancer Treatment Center Gateway | El Paso | Texas | 79915 | — |
| Texas Oncology - El Paso Cancer Treatment Center Joe Battle | El Paso | Texas | 79938 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| Investigational Products Center (IPC) | Fort Worth | Texas | 76177 | — |
| Texas Oncology-Memorial City | Houston | Texas | 77024 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University Of Texas, Md Anderson Cancer Center | Houston | Texas | 77030 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center(IPC) | Irving | Texas | 75063 | — |
| Texas Oncology-Plano East | Plano | Texas | 75075-7787 | — |
| Texas Oncology-Seton Williamson | Round Rock | Texas | 78665 | — |
| Texas Oncology - Waco | Waco | Texas | 76712 | — |
| Texas Oncology-Waco | Waco | Texas | 76712 | — |
| The Center for Cancer and Blood Disorders | Weatherford | Texas | 76086 | — |
| Virginia Cancer Specialists, PC | Alexandria | Virginia | 22304 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Northwest Cancer Specialists, P.C.(Admin Only) | Vancouver | Washington | 98683 | — |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 155 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01945775, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 20, 2022 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01945775 live on ClinicalTrials.gov.