Sleep, Aging and Risk for Alzheimer's Disease

ClinicalTrials.gov ID: NCT01962779

Public ClinicalTrials.gov record NCT01962779. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

Sleep, Aging and Risk for Alzheimer's Disease (SARA) Study

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial temporal lobe glucose uptake (FDG-PET) and volume (MRI) and progressive memory decline, all of which have been shown to be useful in predicting future dementia in older adults. These findings raise the question as to whether Alzheimer's disease (AD) tissue damage causes SDB in the elderly, or alternatively, if SDB acts as a risk factor for AD neurodegeneration. In the proposed study, we will investigate these mechanistic hypotheses in cognitively normal elderly by examining the longitudinal associations between SDB and cognitive decline, novel MR neuroimaging and CSF biomarkers for neurodegeneration; while our secondary goal is to launch a pilot treatment study to aid in interpreting the mechanistic hypotheses and to examine the effects of nasal continuous positive airway pressure (CPAP) on cognitive decline and neurodegeneration.

Study identification

NCT ID: NCT01962779
Recruitment status: Completed
Study type: Interventional
Phase: Not applicable
Lead sponsor: NYU Langone Health; Other
Enrollment: 235 participants

Conditions and interventions

Conditions

Interventions

Continuous positive airway pressure (CPAP) Other

Other

Eligibility (public fields only)

Age range: 50 Years and older
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 30, 2013
Primary completion: May 2, 2017
Completion: May 2, 2017
Last update posted: Jul 20, 2020

2013 – 2017

United States locations

U.S. sites: 2
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
NYU Sleep Disorders Center	New York	New York	10016	—
NYU Center for Brain Health	New York	New York	11222	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01962779, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 20, 2020 · Synced Sep 7, 2026

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The complete protocol, eligibility criteria, and contact information for NCT01962779 live on ClinicalTrials.gov.

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