Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2)
Public ClinicalTrials.gov record NCT01969708. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Study of COmparative Treatments for REtinal Vein Occlusion 2 [SCORE2]: a Multicenter, Prospective, Randomized Non-inferiority Trial of Eyes With Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Every 4 Weeks With Intravitreal Aflibercept Every 4 Weeks.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
SCORE2 is a multicenter, prospective, randomized, phase III clinical trial in which all participants enrolled will be followed for up to 2.5 years. SCORE2 is designed as a non-inferiority trial, with study eyes randomized to intravitreal bevacizumab (1.25 mg) every 4 weeks vs. intravitreal aflibercept (2.0 mg) every 4 weeks. SCORE2 aims to determine if bevacizumab is non-inferior to aflibercept for the treatment of macular edema associated with central retinal vein occlusion (CRVO), with the primary outcome of visual acuity measured at Month 6.
Study identification
- NCT ID
- NCT01969708
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 362 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2014 (Actual)
- Primary completion
- Nov 2016 (Actual)
- Completion
- Mar 2021 (Actual)
- Last update posted
- Jun 22, 2021
2014 – 2021
United States locations
- U.S. sites
- 72
- U.S. states
- 28
- U.S. cities
- 63
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Consultants of AZ | Phoenix | Arizona | 85014 | — |
| Retina Centers, P.C. | Tucson | Arizona | 85704 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| East Bay Retina Consultants, Inc. | Oakland | California | 94609 | — |
| Southern California Desert Retina Consultants | Palm Desert | California | 92211 | — |
| University of California Davis, Medical Center | Sacramento | California | 95817 | — |
| Retinal Consultants Medical Group, Inc. | Sacramento | California | 95819 | — |
| University of California, San Francisco | San Francisco | California | 94143 | — |
| New England Retina Associates | New London | Connecticut | 06320 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| University of Florida, Dept of Ophthalmology | Jacksonville | Florida | 32209 | — |
| Florida Retina Consultants | Lakeland | Florida | 33805 | — |
| Sarasota Retina Institute | Sarasota | Florida | 34239 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Florida Retina Consultants | Winter Haven | Florida | 33880 | — |
| Emory University Eye Center | Atlanta | Georgia | 30322 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina, P.C. | Marietta | Georgia | 30060 | — |
| Illinois Eye and Ear Infirmary UIC Dept. of Ophthalmology | Chicago | Illinois | 60612 | — |
| Thomas A. Ciulla, MD, PC | Indianapolis | Indiana | 46290 | — |
| Sabates Eye Centers | Leawood | Kansas | 66211 | — |
| Retina Associates, PA | Shawnee Mission | Kansas | 66204 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Elman Retina Group, PA | Baltimore | Maryland | 21237 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Elman Retina Group, P.A. | Glen Burnie | Maryland | 21061 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Elman Retina Group, P.A. | Pikesville | Maryland | 21208 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| TLC Eyecare & Laser Centers | Jackson | Michigan | 49202 | — |
| VitreoRetinal Surgery | Minneapolis | Minnesota | 55435 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| UNMC Truhlsen Eye Institute | Omaha | Nebraska | 68198 | — |
| Retina Consultants of Nevada | Las Vegas | Nevada | 89144 | — |
| Delaware Valley Retina Associates | Lawrenceville | New Jersey | 08648 | — |
| NJ Retina | New Brunswick | New Jersey | 08901 | — |
| New York Eye and Ear Infirmary | New York | New York | 10003 | — |
| Retina Associates of Western New York | Rochester | New York | 14620 | — |
| University of Rochester Flaum Eye Institute | Rochester | New York | 14642 | — |
| Retina Vitreous Surgeon of CNY, PC | Syracuse | New York | 13224 | — |
| Charlotte Eye Ear Nose & Throat Associates, P.A. | Charlotte | North Carolina | 28210 | — |
| Charlotte Eye Ear Nose & Throat Associates, P.A. | Statesville | North Carolina | 28677 | — |
| Retina Associates of Cleveland, Inc. | Cleveland | Ohio | 44122 | — |
| The Ohio State University | Columbus | Ohio | 43212 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Casey Eye Institute / OHSU | Portland | Oregon | 97239 | — |
| Retina Vitreous Consultants | Monroeville | Pennsylvania | 15146 | — |
| Scheie Eye Institute | Philadelphia | Pennsylvania | 19104 | — |
| Carolinas Centers for Sight, PC | Florence | South Carolina | 29501 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37909 | — |
| Tennessee Retina, PC | Nashville | Tennessee | 37203 | — |
| Vanderbilt Eye Institute | Nashville | Tennessee | 37232-8808 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| The Retina Research Center | Austin | Texas | 78705 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Charlotte Eye Ear Nose & Throat Associates, P.A. | Houston | Texas | 77025 | — |
| Retina & Vitreous of Texas | Houston | Texas | 77025 | — |
| Retina Consultants of Houston, PA | Houston | Texas | 77030 | — |
| Valley Retina Institute, PA | McAllen | Texas | 78503 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| The Retina Group of Washington | Fairfax | Virginia | 22031 | — |
| University of Wisconsin | Madison | Wisconsin | 53705 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01969708, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 22, 2021 · Synced Oct 31, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01969708 live on ClinicalTrials.gov.