Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure
Public ClinicalTrials.gov record NCT01970501. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
GENETIC-AF - A Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Symptomatic Atrial Fibrillation/Atrial Flutter in Patients With Heart Failure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (Toprol-XL) on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.
Study identification
- NCT ID
- NCT01970501
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 267 participants
Conditions and interventions
Interventions
- bucindolol hydrochloride Drug
- metoprolol succinate Drug
- Placebo oral capsule Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2014 (Type not available)
- Primary completion
- Dec 28, 2017 (Actual)
- Completion
- Dec 28, 2017 (Actual)
- Last update posted
- Sep 26, 2022
2014 – 2017
United States locations
- U.S. sites
- 48
- U.S. states
- 27
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ARCA Clinical Research Site #157 | Anchorage | Alaska | 99508 | — |
| ARCA Clinical Research Site #383 | Phoenix | Arizona | 85004 | — |
| ARCA Clinical Research Site #385 | Phoenix | Arizona | 85018 | — |
| ARCA Clinical Research Site #381 | East Palo Alto | California | 94303 | — |
| ARCA Clinical Research Site #186 | Loma Linda | California | 92357 | — |
| ARCA Clinical Research Site #320 | Pasadena | California | 91105 | — |
| ARCA Clinical Research Site #390 | Stanford | California | 94305 | — |
| ARCA Clinical Research Site #153 | Aurora | Colorado | 80045 | — |
| ARCA Clinical Research Site #380 | Denver | Colorado | 80120 | — |
| ARCA Clinical Research Site #195 | Miami | Florida | 33136 | — |
| ARCA Clinical Research Site #184 | Tampa | Florida | 33606 | — |
| ARCA Clinical Research Site #351 | Athens | Georgia | 30606 | — |
| ARCA Clinical Research Site #389 | Atlanta | Georgia | 30322 | — |
| ARCA Clinical Research Site #342 | Oakbrook Terrace | Illinois | 60181 | — |
| ARCA Clinical Research Site #303 | Hammond | Indiana | 46320 | — |
| ARCA Clinical Research Site #388 | Iowa City | Iowa | 52242 | — |
| ARCA Clinical Site #396 | New Orleans | Louisiana | 70121 | — |
| ARCA Clinical Research Site #398 | Baltimore | Maryland | 21287 | — |
| ARCA Clinical Research Site #127 | Ypsilanti | Michigan | 48197 | — |
| ARCA Clinical Research Site #156 | Minneapolis | Minnesota | 55417 | — |
| ARCA Clinical Research Site #174 | Saint Paul | Minnesota | 55102 | — |
| ARCA Clinical Research Site #108 | St Louis | Missouri | 63110 | — |
| ARCA Clinical Research Site #201 | St Louis | Missouri | 63128 | — |
| ARCA Clinical Research Site #152 | Lincoln | Nebraska | 68506 | — |
| ARCA Clinical Research Site #161 | Elmer | New Jersey | 08318 | — |
| ARCA Clinical Research Site #202 | Hillsborough | New Jersey | 08844 | — |
| ARCA Clinical Research Site # 179 | Albany | New York | 12205 | — |
| ARCA Clinical Research Site #397 | New York | New York | 10029 | — |
| ARCA Clinical Research Site #181 | Durham | North Carolina | 27705 | — |
| ARCA Clinical Research Site #349 | Greensboro | North Carolina | 27401 | — |
| ARCA Clinical Research Site #173 | Akron | Ohio | 44304 | — |
| ARCA Clinical Research Site #392 | Cincinnati | Ohio | 45219 | — |
| ARCA Clinical Research Site #322 | Cleveland | Ohio | 44106 | — |
| ARCA Clinical Research Site #151 | Columbus | Ohio | 43210 | — |
| ARCA Clinical Research Site #399 | Oklahoma City | Oklahoma | 73135 | — |
| ARCA Clinical Research Site #115 | Portland | Oregon | 97201 | — |
| ARCA Clinical Research Site # 189 | Hershey | Pennsylvania | 17033 | — |
| ARCA Clinical Research Site #109 | Lancaster | Pennsylvania | 17603 | — |
| ARCA Clinical Research Site #133 | Philadelphia | Pennsylvania | 19104 | — |
| ARCA Clinical Site #393 | Germantown | Tennessee | 38138 | — |
| ARCA Clinical Research Site #198 | Jackson | Tennessee | 38305 | — |
| ARCA Clinical Research Site #387 | Dallas | Texas | 75230 | — |
| ARCA Clinical Research Site #379 | Salt Lake City | Utah | 84132 | — |
| ARCA Clinical Site #391 | Charlottesville | Virginia | 22908 | — |
| ARCA Clinical Research Site #386 | Falls Church | Virginia | 22042 | — |
| ARCA Clinical Research Site #200 | Manassas | Virginia | 20109 | — |
| ARCA Research Site #131 | Norfolk | Virginia | 23507 | — |
| ARCA Clinical Research Site #196 | Puyallup | Washington | 98372 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01970501, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 26, 2022 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01970501 live on ClinicalTrials.gov.