Bolus of Saline in Stroke

ClinicalTrials.gov ID: NCT01971463

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ClinicalTrials.gov public records Last synced Nov 13, 2026, 5:56 AM EST

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Official title

Optical Measurement of Cerebral Blood Flow Response After Ischemic Stroke

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is a non-randomized, Phase 2 clinical trial designed to assess optical cerebral blood flow (CBF) response to bolus normal saline. Subjects will have had an ischemic stroke within 96 hours of enrollment. The study intervention will be a one hour monitoring session. There will be a 15 minute baseline measurement period, followed by intravenous administration of 500cc of 0.9% NaCl over 30 minutes, and finally 15 minutes of monitoring post-bolus. All study measurements will cease after 1 hour. Subjects will be followed during their hospitalization for 7 days or until discharge, whichever is sooner, to monitor for adverse events and to collect clinical information.

Study identification

NCT ID: NCT01971463
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of Pennsylvania; Other
Enrollment: 81 participants

Conditions and interventions

Conditions

Ischemic Stroke

Interventions

Normal saline Other

Other

Eligibility (public fields only)

Age range: 18 Years to 110 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 2013 (Type not available)
Primary completion: Sep 2016 (Actual)
Completion: Sep 2019 (Actual)
Last update posted: Dec 4, 2019

2013 – 2019

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
University of Pennsylvania	Philadelphia	Pennsylvania	19104	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01971463, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 4, 2019 · Synced Nov 13, 2026