A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week, Dose-Range-Finding Trial of YKP10811 Capsules Administered Once Daily to Subjects With Chronic Idiopathic Constipation
Public ClinicalTrials.gov record NCT01989234. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This will be a multi-center, randomized, double-blind, placebo-controlled study of YKP10811 capsules in patients with chronic idiopathic constipation. Following a 2-week baseline period, approximately 320 eligible patients with \<3 complete spontaneous bowel movements (CSBM) and ≤ 5 SBMs per week will be randomly assigned equally to receive one of the following oral treatments; placebo or YKP10811 capsules once daily for 12 weeks followed by a 2 week follow-up period. The objectives of this study are: * To assess the efficacy of YKP10811 once daily at relieving constipation and associated symptoms in subjects with chronic idiopathic constipation. * To determine the safety and tolerability of YKP10811 once daily in subjects with chronic idiopathic constipation.
Study identification
- NCT ID
- NCT01989234
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 334 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 30, 2013
- Primary completion
- Aug 31, 2014
- Completion
- Nov 30, 2014
- Last update posted
- Dec 18, 2014
2013 – 2014
United States locations
- U.S. sites
- 69
- U.S. states
- 29
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance Clinical Research | Birmingham | Alabama | 35213 | — |
| Clinical Research Advantage, Inc. / Warner Family Practice, PC | Chandler | Arizona | 85224 | — |
| Connect Clinical Research Center | Chandler | Arizona | 85224 | — |
| Clinical Research Advantage, Inc. / Central Phoenix Medical Clinic, LLC | Phoenix | Arizona | 85020 | — |
| Arizona Research Center | Phoenix | Arizona | 85023 | — |
| Applied Research Center Arkansas, Inc. | Little Rock | Arkansas | 72212 | — |
| Digestive & Liver Disease Specialists, A Medical Group, Inc. | Anaheim | California | 92801 | — |
| Precision Research Institute | Chula Vista | California | 91910 | — |
| Triwest Research Associates, LLC | El Cajon | California | 92020 | — |
| Diagnamics Inc. | Encinitas | California | 92024 | — |
| Therapeutic Research Institute of Orange County | Laguna Hills | California | 92653 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Alliance Clinical Research | Oceanside | California | 92056 | — |
| Northern California Research | Sacramento | California | 95821 | — |
| Clinical Research Advantage, Inc. / Colorado Springs Health Partners, SW | Colorado Springs | Colorado | 80906 | — |
| Meridien Research | Bradenton | Florida | 34208 | — |
| Palm Springs Research Institute | Hialeah | Florida | 33012 | — |
| The Clinical Research Institute | Miami | Florida | 33125 | — |
| Prestige Clinical Research Center Inc. | Miami | Florida | 33133 | — |
| Physicians Regional Medical Group | Naples | Florida | 34119 | — |
| Advanced Gastroenterology Associates, LLC | Palm Harbor | Florida | 34684 | — |
| Clinical Research Trials of Florida, Inc. | Tampa | Florida | 33607 | — |
| River Birch Research Alliance, LLC | Blue Ridge | Georgia | 30513 | — |
| Gastroenterology Associates of Central Georgia, LLC | Macon | Georgia | 31201 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| May Medical Center | Chicago | Illinois | 60624 | — |
| Pharmakon Inc. | Evergreen Park | Illinois | 60805 | — |
| Clinical Research Advantage, Inc. | Evansville | Indiana | 47714 | — |
| KAMP Medical Research, Inc. | Natchitoches | Louisiana | 71457 | — |
| Clinical Associates Ambulatory Surgical Center | Towson | Maryland | 21286 | — |
| The Research Institute | Springfield | Massachusetts | 01105 | — |
| Coastal Research Associates, Inc. | Weymouth | Massachusetts | 02190 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Clinical Research Advantage, Inc. | Henderson | Nevada | 89052 | — |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | — |
| Clinical Research Center of Nevada | Las Vegas | Nevada | 89130 | — |
| Not listed | Las Vegas | Nevada | 89144 | — |
| AGA Clinical Research Associates, LLC | Egg Harbor | New Jersey | 08234 | — |
| HBSA, A Supporting Organization of Pacific Institute for Research and Evaluation | Albuquerque | New Mexico | 87102 | — |
| NY Scientific | Brooklyn | New York | 11235 | — |
| Medex Healthcare Research, Inc. | New York | New York | 10016 | — |
| PMG Research of Charlotte | Charlotte | North Carolina | 28209 | — |
| PMG Research of Charlotte | Concord | North Carolina | 28025 | — |
| PMG Research of Hickory, LLC | Hickory | North Carolina | 28605 | — |
| PMG Research of Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Dayton Gastroenterology, Inc. | Beavercreek | Ohio | 45440 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45219 | — |
| Hilltop Physicians IN / Hightop Medical Research Center | Cincinnati | Ohio | 45224 | — |
| New Horizons Clinical Research | Cincinnati | Ohio | 45242 | — |
| Columbus Clinical Research Inc. | Columbus | Ohio | 43213 | — |
| COR Clinical Research, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Options Health Research, LLC | Tulsa | Oklahoma | 74104 | — |
| Sunstone Medical Research, LLC | Medford | Oregon | 97504 | — |
| The Oregon Clinic, PC - Gastroenterology West | Portland | Oregon | 97225 | — |
| Clinical Trials Research Services, LLC | Pittsburgh | Pennsylvania | 15206 | — |
| Partners in Clinical Research, LLC | Cumberland | Rhode Island | 02864 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Alpha Clinical Research, LLC | Clarksville | Tennessee | 37043 | — |
| Austin Center for Clinical Research | Austin | Texas | 78756 | — |
| MW Clinical Research Center | Beaumont | Texas | 77702 | — |
| Houston Endoscopy & Research Center | Houston | Texas | 77079 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Radiant Research Inc. | San Antonio | Texas | 78229 | — |
| Digestive Health Specialists of Tyler, LLP | Tyler | Texas | 75701 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Health Research of Hampton Roads, Inc. | Newport News | Virginia | 23606 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01989234, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 18, 2014 · Synced Sep 24, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01989234 live on ClinicalTrials.gov.