A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema
Public ClinicalTrials.gov record NCT01994291. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Masked, Placebo-Controlled, Parallel Group, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist (PF-04634817) With That Of Ranibizumab In Adult Subjects With Diabetic Macular Edema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study hypothesis under test is that administration of the CCR2/5 antagonist has the potential to be as effective as the current treatment options for subjects with diabetic macular edema. The current treatment option for these subjects is an injection directly into the eye, while this CCR2/5 antagonist would be an oral drug which has the potential to be just as effective. This CCR2/5 antagonist also has a broader anti-inflammatory potential and might be able to provide an alternative mechanism to treat Diabetic Macular Edema.
Study identification
- NCT ID
- NCT01994291
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 199 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2013 (Type not available)
- Primary completion
- Aug 2015 (Actual)
- Completion
- Aug 2015 (Actual)
- Last update posted
- Oct 17, 2016
2013 – 2015
United States locations
- U.S. sites
- 33
- U.S. states
- 15
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Research Institute, LLC | Phoenix | Arizona | 85014 | — |
| Retinal Consultants of Arizona | Phoenix | Arizona | 85014 | — |
| Sunny View Medical Center | Phoenix | Arizona | 85018 | — |
| Premier Research Group Limited | Phoenix | Arizona | 85027 | — |
| Retina Centers, P.C. | Tucson | Arizona | 85704 | — |
| Retina Institute of California | Arcadia | California | 91007 | — |
| Retina Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| Retina Associates of Orange County | Laguna Hills | California | 92653 | — |
| Southern California Desert Retina Consultants | Palm Desert | California | 92211 | — |
| American Institute of Research (Administrative Only) | Whittier | California | 90603 | — |
| New England Retina Associates | New London | Connecticut | 06320 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center, PC | Augusta | Georgia | 30909 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| TLC Eyecare & Laser Center | Jackson | Michigan | 49202 | — |
| Wm Beaumont Medical Office Building | Royal Oak | Michigan | 48073 | — |
| Charlotte Eye Ear Nose and Throat Associates PA | Charlotte | North Carolina | 28210 | — |
| Retina Associates of Cleveland, Inc. | Cleveland | Ohio | 44122 | — |
| Retina Associates of Cleveland | Youngstown | Ohio | 44505 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| University of Oklahoma -OU Physicians | Oklahoma City | Oklahoma | 73104 | — |
| Retina Vitreous Consultants | Pittsburgh | Pennsylvania | 15213 | — |
| Associates in Ophthalmology Ltd | West Mifflin | Pennsylvania | 15122 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Brain B.Berger,MD,PA | Austin | Texas | 78705 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Retina Consultants of Houston, PA | Houston | Texas | 77030 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Rocky Mountain Retina Consultants | Salt Lake City | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01994291, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 17, 2016 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01994291 live on ClinicalTrials.gov.