Safety and Efficacy Study of Abraxane as Maintenance Treatment After Abraxane Plus Carboplatin in 1st Line Stage IIIB / IV Squamous Cell Non-small Cell Lung Cancer
Public ClinicalTrials.gov record NCT02027428. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Open-Label, Multi-Center, Safety and Efficacy Study to Evaluate Nab-Paclitaxel (Abraxane®) as Maintenance Treatment After Induction With Nab-Paclitaxel Plus Carboplatin in Subjects With Squamous Cell Non-Small Cell Lung Cancer (NSCLC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Maintenance treatment of advanced stage squamous cell NSCLC. Phase III, randomized, open-label, multi-center study of nab-paclitaxel with best supportive care (BSC) or BSC alone as maintenance treatment after response or stable disease (SD) with nab-paclitaxel plus carboplatin as induction in subjects with stage IIIB/IV squamous cell NSCLC. Subjects who discontinued treatment from the maintenance part for any reason other than withdrawal of consent, lost to follow-up, or death, were entered into a Follow-up period that had a visit 28 days after progression or discontinuation. Those who entered Follow-up without progression continued with follow-up scans according to standard of care (SOC) until documentation of progression of disease. Additionally, subjects were followed for OS by phone approximately every 90 days for a minimum of 18 months, for up to approximately 5 years after the last subject was randomized.
Study identification
- NCT ID
- NCT02027428
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 427 participants
Conditions and interventions
Conditions
Interventions
- Abraxane (Induction) Drug
- Carboplatin (Induction) Drug
- Abraxane (Maintenance) Drug
- Best Supportive Care (Maintenance) Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 11, 2014 (Actual)
- Primary completion
- Sep 15, 2017 (Actual)
- Completion
- Aug 1, 2019 (Actual)
- Last update posted
- Aug 17, 2020
2014 – 2019
United States locations
- U.S. sites
- 91
- U.S. states
- 30
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clearview Cancer Institute Oncology Specialties, P.C | Huntsville | Alabama | 35805 | — |
| Palo Verde Hematology Oncology, Ltd. | Glendale | Arizona | 85304 | — |
| Arizona Clinical Research Center | Tucson | Arizona | 85715 | — |
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | — |
| City of Hope Cancer Center | Duarte | California | 91010-3000 | — |
| Cancer Care Associates of Fresno Medical Group Inc | Fresno | California | 93720 | — |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Clinical Trials and Research Associates | Montebello | California | 90640 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304 | — |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218 | — |
| Yale Cancer Center | New Haven | Connecticut | 06510 | — |
| Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33916 | — |
| Watson Clinic, LLP Center for Cancer Care and Research | Lakeland | Florida | 33805 | — |
| University of Miami Miller School of Medicine Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Ocala Oncology Center | Ocala | Florida | 34474 | — |
| Orlando Health, Inc | Orlando | Florida | 32806 | — |
| Memorial Cancer Institute West | Pembroke Pines | Florida | 33028 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| University Cancer and Blood Center, LLC | Athens | Georgia | 30607 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Joliet Oncology-Hematology Associates, Ltd. | Joliet | Illinois | 60435 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Indiana University Medical Center | Indianapolis | Indiana | 46202-5149 | — |
| Investigative Clinical Research of Indiana, LLC | Indianapolis | Indiana | 46260 | — |
| Kansas University Medical Center | Westwood | Kansas | 66205 | — |
| Cancer Center of Kansas (MAT) | Wichita | Kansas | 67208 | — |
| Kentucky Cancer Clinic | Hazard | Kentucky | 41701 | — |
| Norton Healthcare | Louisville | Kentucky | 40202 | — |
| University of Louisville, J.G. Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute Louisville Oncology | Louisville | Kentucky | 40207 | — |
| LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Maine Research Associates | Auburn | Maine | 04210 | — |
| Eastern Maine Medical Center | Brewer | Maine | 04412 | — |
| Center For Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Meritus Medical Center | Hagerstown | Maryland | 21742 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | — |
| Detroit Clinical Research Center | Farmington Hills | Michigan | 48334 | — |
| Western Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| St Joseph Oncology | Saint Joseph | Missouri | 64507 | — |
| Mercy Medical Research Institute | Springfield | Missouri | 65804 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Hematology-Oncology Associates of NNJ, P | Morristown | New Jersey | 07960 | — |
| New York Oncology Hematology P.C. | Albany | New York | 12206 | — |
| Clinical Research Alliance | Lake Success | New York | 11042 | — |
| NYU Langone Medical Center | Lake Success | New York | 11042 | — |
| Beth Israel Medical Centers | New York | New York | 10003 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai Medical Center | New York | New York | 10029 | — |
| Rochester General Hospital | Rochester | New York | 14621 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Montefiore Medical Center Albert Einstein Cancer Center | The Bronx | New York | 10467 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28204 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Moses H. Cone Regional Cancer Center | Greensboro | North Carolina | 27403 | — |
| Hematology and Oncology Associates, Inc. | Canton | Ohio | 44708 | — |
| Oncology Hematology Care, Inc. | Cincinnati | Ohio | 45242 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| The Mark H. Zangmeister Center | Columbus | Ohio | 43219 | — |
| Tri-County Hematology and Oncology Associates | Massillon | Ohio | 44646 | — |
| Toledo Community Oncology Program | Toledo | Ohio | 43623 | — |
| Mercy Clinic Oklahoma Communities, Inc. | Oklahoma City | Oklahoma | 73102 | — |
| University of Oklahoma Peggy and Charles Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Erie Regional Cancer Center | Erie | Pennsylvania | 16505 | — |
| Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| University of Pennsylvania Health Systems | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny Singer Research Institute | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center - Cancer Pavilion | Pittsburgh | Pennsylvania | 15232 | — |
| Greenville Hospital System | Greenville | South Carolina | 29605 | — |
| Chattanooga Oncology Hematology Care | Chattanooga | Tennessee | 37404 | — |
| Associates in Oncology and Hematology | Chattanooga | Tennessee | 37421 | — |
| Thompson Cancer Survival Center | Knoxville | Tennessee | 37916 | — |
| Sarah Cannon Cancer Center | Nashville | Tennessee | 37203-1632 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| TX Onc, PA- Beaumont | Beaumont | Texas | 77702-1449 | — |
| Brooke Army Medical Center Francis Street Medical Center | Fort Sam Houston | Texas | 78235-8200 | — |
| Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| UT Health Oncology | Houston | Texas | 77030 | — |
| Millenium Oncology | Houston | Texas | 77090 | — |
| TX Onc Tyler Cancer Center | Tyler | Texas | 75702 | — |
| Columbia Basin Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| St Mary's Medical Center | Huntington | West Virginia | 25702 | — |
| West Virginia University, Berkeley Medical Center, Cancer and Infusion Center | Martinsburg | West Virginia | 25401 | — |
| West Virginia University, Berkeley Medical Center, Cancer and Infusion Center | Morgantown | West Virginia | 26506 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 28 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02027428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 17, 2020 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02027428 live on ClinicalTrials.gov.