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ClinicalTrials.gov record
Completed Phase 2 Interventional Results available

Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery

ClinicalTrials.gov ID: NCT02042443

Public ClinicalTrials.gov record NCT02042443. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 25, 2026, 7:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II Trial of Single Agent MEK Inhibitor Trametinib (GSK1120212) Vs 5-Fluorouracil or Capecitabine in Refractory Advanced Biliary Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase II trial studies how well trametinib or combination chemotherapy works in treating patients with refractory or advanced biliary or gallbladder cancer or that cannot be removed by surgery. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fluorouracil, leucovorin calcium, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving trametinib is more effective than combination chemotherapy in treating patients with biliary or gallbladder cancer.

Study identification

NCT ID
NCT02042443
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Enrollment
53 participants

Conditions and interventions

Eligibility (public fields only)

Age range
Not listed
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 2014 (Type not available)
Primary completion
Jan 2017 (Actual)
Completion
Apr 30, 2017 (Actual)
Last update posted
Sep 12, 2017

2014 – 2017

United States locations

U.S. sites
295
U.S. states
28
U.S. cities
192
Facility City State ZIP Site status
Alaska Breast Care and Surgery LLC Anchorage Alaska 99508 —
Alaska Women's Cancer Care Anchorage Alaska 99508 —
Anchorage Oncology Centre Anchorage Alaska 99508 —
Katmai Oncology Group Anchorage Alaska 99508 —
Providence Alaska Medical Center Anchorage Alaska 99508 —
Kaiser Permanente-Anaheim Anaheim California 92807 —
Sutter Auburn Faith Hospital Auburn California 95602 —
Kaiser Permanente-Baldwin Park Baldwin Park California 91706 —
Kaiser Permanente-Bellflower Bellflower California 90706 —
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 —
Mills - Peninsula Hospitals Burlingame California 94010 —
Sutter Davis Hospital Davis California 95616 —
City of Hope Comprehensive Cancer Center Duarte California 91010 —
Kaiser Permanente Hospital Fontana California 92335 —
Kaiser Permanente - Harbor City Harbor City California 90710 —
Kaiser Permanente-Irvine Irvine California 92618 —
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 —
Los Angeles County-USC Medical Center Los Angeles California 90033 —
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 —
Kaiser Permanente-Cadillac Los Angeles California 90034 —
Fremont - Rideout Cancer Center Marysville California 95901 —
Memorial Medical Center Modesto California 95355 —
Palo Alto Medical Foundation-Camino Division Mountain View California 94040 —
Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California 94040 —
Sutter Cancer Research Consortium Novato California 94945 —
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 —
Palo Alto Medical Foundation Health Care Palo Alto California 94301 —
Kaiser Permanente - Panorama City Panorama City California 91402 —
Kaiser Permanente-Riverside Riverside California 92505 —
Sutter Roseville Medical Center Roseville California 95661 —
Sutter General Hospital Sacramento California 95816 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
Kaiser Permanente-San Diego Mission San Diego California 92108 —
Kaiser Permanente-San Diego Zion San Diego California 92120 —
California Pacific Medical Center-Pacific Campus San Francisco California 94115 —
Kaiser Permanente-San Marcos San Marcos California 92069 —
Palo Alto Medical Foundation-Santa Cruz Santa Cruz California 95065 —
Sutter Pacific Medical Foundation Santa Rosa California 95403 —
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086 —
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 —
Kaiser Permanente Woodland Hills California 91367 —
University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora Colorado 80045 —
Memorial Hospital Colorado Springs Colorado Springs Colorado 80909 —
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418 —
Medical Oncology and Hematology Group PC-Guilford Guilford Connecticut 06437 —
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 —
Yale University New Haven Connecticut 06520 —
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473 —
Smilow Cancer Hospital-Orange Care Center Orange Connecticut 06477 —
Charlotte Hungerford Hospital Center for Cancer Care Torrington Connecticut 06790 —
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708 —
University of Florida Gainesville Florida 32610 —
Moffitt Cancer Center Tampa Florida 33612 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Kootenai Medical Center Coeur d'Alene Idaho 83814 —
Kootenai Cancer Center Post Falls Idaho 83854 —
Kootenai Cancer Clinic Sandpoint Idaho 83864 —
Saint Joseph Medical Center Bloomington Illinois 61701 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Memorial Hospital of Carbondale Carbondale Illinois 62902 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Cancer Care Center of Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Crossroads Cancer Center Effingham Illinois 62401 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Western Illinois Cancer Treatment Center Galesburg Illinois 61401 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Loyola University Medical Center Maywood Illinois 60153 —
Good Samaritan Regional Health Center Mount Vernon Illinois 62864 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Radiation Oncology of Northern Illinois Ottawa Illinois 61350 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois 61554 —
Methodist Medical Center of Illinois Peoria Illinois 61603 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois 61615 —
OSF Saint Francis Medical Center Peoria Illinois 61637 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Valley Radiation Oncology Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Central Illinois Hematology Oncology Center Springfield Illinois 62702 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62703 —
Memorial Medical Center Springfield Illinois 62781 —
Reid Health Richmond Indiana 47374 —
Cancer Center of Kansas - Chanute Chanute Kansas 66720 —
Cancer Center of Kansas - Dodge City Dodge City Kansas 67801 —
Cancer Center of Kansas - El Dorado El Dorado Kansas 67042 —
Newman Regional Health Emporia Kansas 66801 —
Cancer Center of Kansas - Fort Scott Fort Scott Kansas 66701 —
Saint Catherine Hospital Garden City Kansas 67846 —
Saint Rose Ambulatory and Surgery Center Great Bend Kansas 67530 —
Hays Medical Center Hays Kansas 67601 —
Cancer Center of Kansas-Independence Independence Kansas 67301 —
University of Kansas Cancer Center-West Kansas City Kansas 66112 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Cancer Center of Kansas-Kingman Kingman Kansas 67068 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Cancer Center of Kansas-Liberal Liberal Kansas 67905 —
Cancer Center of Kansas-Manhattan Manhattan Kansas 66502 —
Cancer Center of Kansas - McPherson McPherson Kansas 67460 —
Cancer Center of Kansas - Newton Newton Kansas 67114 —
Olathe Medical Center Olathe Kansas 66061 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Cancer Center of Kansas - Parsons Parsons Kansas 67357 —
Via Christi Hospital-Pittsburg Pittsburg Kansas 66762 —
Cancer Center of Kansas - Pratt Pratt Kansas 67124 —
Cancer Center of Kansas - Salina Salina Kansas 67401 —
Salina Regional Health Center Salina Kansas 67401 —
Saint Francis Hospital and Medical Center - Topeka Topeka Kansas 66606 —
Cancer Center of Kansas - Wellington Wellington Kansas 67152 —
Associates In Womens Health Wichita Kansas 67208 —
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208 —
Cancer Center of Kansas - Wichita Wichita Kansas 67214 —
Via Christi Regional Medical Center Wichita Kansas 67214 —
Wichita NCI Community Oncology Research Program Wichita Kansas 67214 —
Cancer Center of Kansas - Winfield Winfield Kansas 67156 —
Oncology Hematology Care Inc-Crestview Crestview Hills Kentucky 41017 —
Boston Medical Center Boston Massachusetts 02118 —
Lahey Hospital and Medical Center Burlington Massachusetts 01805 —
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106-0995 —
Michigan Cancer Research Consortium NCORP Ann Arbor Michigan 48106 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Beaumont Hospital-Dearborn Dearborn Michigan 48124 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Saint John Hospital and Medical Center Detroit Michigan 48236 —
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 —
Hurley Medical Center Flint Michigan 48502 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Mercy Health Saint Mary's Grand Rapids Michigan 49503 —
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503 —
Allegiance Health Jackson Michigan 49201 —
Sparrow Hospital Lansing Michigan 48912 —
Saint Mary Mercy Hospital Livonia Michigan 48154 —
Mercy Health Mercy Campus Muskegon Michigan 49444 —
Lakeland Community Hospital Niles Michigan 49120 —
Saint Joseph Mercy Oakland Pontiac Michigan 48341 —
Lake Huron Medical Center Port Huron Michigan 48060 —
Spectrum Health Reed City Hospital Reed City Michigan 49677 —
Saint Mary's of Michigan Saginaw Michigan 48601 —
Lakeland Hospital Saint Joseph Michigan 49085 —
Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
Saint John Macomb-Oakland Hospital Warren Michigan 48093 —
Parkland Health Center-Bonne Terre Bonne Terre Missouri 63628 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Southeast Cancer Center Cape Girardeau Missouri 63703 —
Capital Region Medical Center-Goldschmidt Cancer Center Jefferson City Missouri 65109 —
Truman Medical Center Kansas City Missouri 64108 —
The University of Kansas Cancer Center-South Kansas City Missouri 64131 —
The University of Kansas Cancer Center-North Kansas City Missouri 64154 —
The University of Kansas Cancer Center-Lee's Summit Lee's Summit Missouri 64064 —
Phelps County Regional Medical Center Rolla Missouri 65401 —
Saint John's Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401 —
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 —
Cancer Research for the Ozarks NCORP Springfield Missouri 65804 —
Mercy Hospital Springfield Springfield Missouri 65804 —
CoxHealth South Hospital Springfield Missouri 65807 —
Saint Louis Cancer and Breast Institute-South City St Louis Missouri 63109 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 —
Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri 63127 —
Billings Clinic Cancer Center Billings Montana 59101 —
Montana Cancer Consortium NCORP Billings Montana 59101 —
Saint Vincent Healthcare Billings Montana 59101 —
Bozeman Deaconess Hospital Bozeman Montana 59715 —
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701 —
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405 —
Saint Peter's Community Hospital Helena Montana 59601 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Saint Patrick Hospital - Community Hospital Missoula Montana 59802 —
Community Medical Hospital Missoula Montana 59804 —
Cancer and Blood Specialists-Henderson Henderson Nevada 89052 —
Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada 89052 —
Las Vegas Cancer Center-Henderson Henderson Nevada 89052 —
21st Century Oncology - Henderson Henderson Nevada 89074 —
Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada 89074 —
University Medical Center of Southern Nevada Las Vegas Nevada 89102 —
Cancer and Blood Specialists-Shadow Las Vegas Nevada 89106 —
Nevada Cancer Research Foundation CCOP Las Vegas Nevada 89106 —
Radiation Oncology Centers of Nevada Central Las Vegas Nevada 89106 —
21st Century Oncology Las Vegas Nevada 89109 —
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada 89109 —
HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada 89113 —
Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada 89119 —
Cancer Therapy and Integrative Medicine Las Vegas Nevada 89121 —
Cancer and Blood Specialists-Tenaya Las Vegas Nevada 89128 —
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada 89128 —
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada 89128 —
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada 89144 —
Las Vegas Cancer Center-Medical Center Las Vegas Nevada 89148-2405 —
21st Century Oncology - Fort Apache Las Vegas Nevada 89148 —
Cancer and Blood Specialists-Fort Apache Las Vegas Nevada 89148 —
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89148 —
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada 89149 —
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada 89169 —
21st Century Oncology - Vegas Tenaya Las Vegas Nevada 89182 —
University of New Mexico Cancer Center Albuquerque New Mexico 87102 —
Christus Saint Vincent Regional Cancer Center Santa Fe New Mexico 87505 —
Columbia University/Herbert Irving Cancer Center New York New York 10032 —
University of Rochester Rochester New York 14642 —
Cancer Care of Western North Carolina Asheville North Carolina 28801 —
Mission Hospital-Memorial Campus Asheville North Carolina 28801 —
Asheville Hematology-Oncology Associates Asheville North Carolina 28803 —
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 —
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 —
Wayne Memorial Hospital Goldsboro North Carolina 27534 —
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 —
Iredell Memorial Hospital Statesville North Carolina 28677 —
Southeastern Medical Oncology Center-Wilson Wilson North Carolina 27893 —
Southeast Clinical Oncology Research (SCOR) Consortium NCORP Winston-Salem North Carolina 27104 —
Strecker Cancer Center-Belpre Belpre Ohio 45714 —
Adena Regional Medical Center Chillicothe Ohio 45601 —
Oncology Hematology Care Inc-Eden Park Cincinnati Ohio 45202 —
Oncology Hematology Care Inc-Mercy West Cincinnati Ohio 45211 —
Oncology Hematology Care Inc - Anderson Cincinnati Ohio 45230 —
Oncology Hematology Care Inc-Kenwood Cincinnati Ohio 45236 —
Oncology Hematology Care Inc-Blue Ash Cincinnati Ohio 45242 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Columbus NCI Community Oncology Research Program Columbus Ohio 43215 —
Grant Medical Center Columbus Ohio 43215 —
The Mark H Zangmeister Center Columbus Ohio 43219 —
Mount Carmel Health Center West Columbus Ohio 43222 —
Doctors Hospital Columbus Ohio 43228 —
Good Samaritan Hospital - Dayton Dayton Ohio 45406 —
Miami Valley Hospital Dayton Ohio 45409 —
Samaritan North Health Center Dayton Ohio 45415 —
Dayton NCI Community Oncology Research Program Dayton Ohio 45420 —
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 —
Delaware Radiation Oncology Delaware Ohio 43015 —
Grady Memorial Hospital Delaware Ohio 43015 —
Oncology Hematology Care Inc-Healthplex Fairfield Ohio 45014 —
Blanchard Valley Hospital Findlay Ohio 45840 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Wayne Hospital Greenville Ohio 45331 —
Kettering Medical Center Kettering Ohio 45429 —
Fairfield Medical Center Lancaster Ohio 43130 —
Marietta Memorial Hospital Marietta Ohio 45750 —
Knox Community Hospital Mount Vernon Ohio 43050 —
Licking Memorial Hospital Newark Ohio 43055 —
Newark Radiation Oncology Newark Ohio 43055 —
Southern Ohio Medical Center Portsmouth Ohio 45662 —
Springfield Regional Medical Center Springfield Ohio 45505 —
Upper Valley Medical Center Troy Ohio 45373 —
Saint Ann's Hospital Westerville Ohio 43081 —
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Providence Milwaukie Hospital Milwaukie Oregon 97222 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Oregon Health and Science University Portland Oregon 97239 —
Roper Hospital Charleston South Carolina 29401 —
Charleston Hematology Oncology Associates-Roper Charleston South Carolina 29403 —
Lowcountry Hematology Oncology PA-North Charleston Charleston South Carolina 29406 —
Charleston Hematology Oncology Associates PA-St. Francis Charleston South Carolina 29414 —
Lowcountry Hematology Oncology PA-West Ashley Charleston South Carolina 29414 —
Greenville Health System Cancer Institute-Easley Easley South Carolina 29640 —
Saint Francis Hospital Greenville South Carolina 29601 —
Greenville Health System Cancer Institute-Andrews Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Butternut Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Faris Greenville South Carolina 29605 —
Greenville Memorial Hospital Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Eastside Greenville South Carolina 29615 —
Greenville Health System Cancer Institute-Greer Greer South Carolina 29650 —
Gibbs Cancer Center-Pelham Greer South Carolina 29651 —
Lowcountry Hematology Oncology PA-Mount Pleasant Mt. Pleasant South Carolina 29464 —
Greenville Health System Cancer Institute-Seneca Seneca South Carolina 29672 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
Greenville Health System Cancer Institute-Spartanburg Spartanburg South Carolina 29307 —
Wellmont Bristol Regional Medical Center Bristol Tennessee 37620 —
Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City Tennessee 37604 —
Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee 37660 —
Wellmont Medical Associates Oncology and Hematology-Kingsport Kingsport Tennessee 37660 —
The Don and Sybil Harrington Cancer Center Amarillo Texas 79106 —
The Methodist Hospital System Houston Texas 77030 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
Southwest VA Regional Cancer Center Norton Virginia 24273 —
PeaceHealth Saint John Medical Center Longview Washington 98632 —
Swedish Medical Center-First Hill Seattle Washington 98122-4307 —
PeaceHealth Southwest Medical Center Vancouver Washington 98664 —
Rocky Mountain Oncology Casper Wyoming 82609 —
Big Horn Basin Cancer Center Cody Wyoming 82414 —
Billings Clinic-Cody Cody Wyoming 82414 —
Welch Cancer Center Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02042443, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 12, 2017 · Synced Oct 25, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02042443 live on ClinicalTrials.gov.

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