Dimethyl Fumarate (DMF) Observational Study
Public ClinicalTrials.gov record NCT02047097. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis (ESTEEM)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to determine the incidence, type, and pattern of serious adverse events (SAEs), including but not limited to infections (including opportunistic infections), hepatic events, malignancies, and renal events, and of adverse events (AEs) leading to treatment discontinuation in patients with MS treated with dimethyl fumarate (DMF). Secondary objectives of this study in this population are as follows: To determine dimethyl fumarate (DMF) prescription and utilization patterns in routine clinical practice in patients with multiple sclerosis (MS); To assess the effectiveness of dimethyl fumarate (DMF) on multiple sclerosis (MS) disease activity and disability progression in routine clinical practice as determined by the Expanded Disability Status Scale (EDSS) score and multiple sclerosis (MS) relapse information; and To assess the effect of dimethyl fumarate (DMF) on health-related quality of life, healthcare resource consumption, and work productivity.
Study identification
- NCT ID
- NCT02047097
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 5,487 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 19, 2013 (Actual)
- Primary completion
- Oct 31, 2022 (Actual)
- Completion
- Oct 31, 2022 (Actual)
- Last update posted
- May 24, 2023
2013 – 2022
United States locations
- U.S. sites
- 168
- U.S. states
- 40
- U.S. cities
- 143
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35209 | — |
| Research Site | Huntsville | Alabama | 35801 | — |
| Research Site | Gilbert | Arizona | 85234 | — |
| Research Site | Phoenix | Arizona | 85006 | — |
| Research Site | Phoenix | Arizona | 85018 | — |
| Research Site | Phoenix | Arizona | 85048 | — |
| Research Site | Scottsdale | Arizona | 85251 | — |
| Research Site | Tucson | Arizona | 85718 | — |
| Research Sites | Fullerton | California | 92835 | — |
| Research Site | Hanford | California | 93230 | — |
| Research Site | Loma Linda | California | 92354 | — |
| Research Site | Los Angeles | California | 90015 | — |
| Research Site | Los Angeles | California | 90048 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | San Francisco | California | 94158 | — |
| Research Site | Santa Ana | California | 92704 | — |
| Research Site | Aurora | Colorado | 80045 | — |
| Research Site | Colorado Springs | Colorado | 80907 | — |
| Research Site | Denver | Colorado | 80210 | — |
| Research Site | Fort Collins | Colorado | 80528 | — |
| Research Site | Danbury | Connecticut | 06810 | — |
| Research Site | Derby | Connecticut | 06418 | — |
| Research Site | Hartford | Connecticut | 06112 | — |
| Research Site | Norwich | Connecticut | 06360 | — |
| Research Site | Dover | Delaware | 19901 | — |
| Research Site | Wilmington | Delaware | 19801 | — |
| Research Site | Washington D.C. | District of Columbia | 20007 | — |
| Research Site | Washington D.C. | District of Columbia | 20037 | — |
| Research Sites | Boca Raton | Florida | 33486 | — |
| Research Site | Gainesville | Florida | 32610 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Sites | Lighthouse PT | Florida | 33064 | — |
| Research Site | Maitland | Florida | 32751 | — |
| Research Site | Miami | Florida | 33125 | — |
| Research Site | Port Charlotte | Florida | 33952 | — |
| Research Site | Sarasota | Florida | 34233 | — |
| Research Site | St. Petersburg | Florida | 33710 | — |
| Research Site | St. Petersburg | Florida | 33713 | — |
| Research Site | Tampa | Florida | 33606 | — |
| Research Sites | Atlanta | Georgia | 30309 | — |
| Research Site | Atlanta | Georgia | 30309 | — |
| Research Site | Atlanta | Georgia | 30327 | — |
| Research Site | Augusta | Georgia | 30912 | — |
| Research Site | Columbus | Georgia | 31909 | — |
| Research Site | Savannah | Georgia | 31406 | — |
| Research Site | Chicago | Illinois | 60611 | — |
| Research Site | Chicago | Illinois | 60637 | — |
| Research Site | Evanston | Illinois | 60201 | — |
| Research Site | Herrin | Illinois | 62948 | — |
| Research Site | Peoria | Illinois | 61603 | — |
| Research Site | Winfield | Illinois | 60190 | — |
| Research Site | Elkhart | Indiana | 46514 | — |
| Research Site | Indianapolis | Indiana | 46202 | — |
| Research Site | Des Moines | Iowa | 50309 | — |
| Research Site | Des Moines | Iowa | 50314 | — |
| Research Site | Waterloo | Iowa | 50702 | — |
| Research Site | Overland Park | Kansas | 66211 | — |
| Research Site | Overland Park | Kansas | 66212 | — |
| Research Site | Henderson | Kentucky | 42420 | — |
| Research Site | Louisville | Kentucky | 40207 | — |
| Research Site | Hammond | Louisiana | 70403 | — |
| Research Site | New Orleans | Louisiana | 70121 | — |
| Research Site | Rockport | Maine | 04856 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Baltimore | Maryland | 21287 | — |
| Research Site | Bethesda | Maryland | 20814 | — |
| Research Site | Cumberland | Maryland | 21502 | — |
| Research Site | Glen Burnie | Maryland | 21061 | — |
| Research Site | Boston | Massachusetts | 02111 | — |
| Research Site | Boston | Massachusetts | 02135 | — |
| Research Site | Foxborough | Massachusetts | 02035 | — |
| Research Site | Jamaica Plain | Massachusetts | 02130 | — |
| Research Site | Lexington | Massachusetts | 02421 | — |
| Research Site | Wellesley | Massachusetts | 02481 | — |
| Research Site | Worcester | Massachusetts | 01655 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | East Lansing | Michigan | 48824 | — |
| Research Site | Farmington Hills | Michigan | 48334 | — |
| Research Site | West Bloomfield | Michigan | 48322 | — |
| Research Site | Edina | Minnesota | 55435 | — |
| Research Sites | Minneapolis | Minnesota | 55407 | — |
| Research Site | Ocean Springs | Mississippi | 39564 | — |
| Research Site | Springfield | Missouri | 65806 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | Billings | Montana | 59101 | — |
| Research Site | Great Falls | Montana | 59405 | — |
| Research Sites | Lincoln | Nebraska | 68506 | — |
| Research Site | Lincoln | Nebraska | 68521 | — |
| Research Site | Wahoo | Nebraska | 68066 | — |
| Research Site | Las Vegas | Nevada | 89106 | — |
| Research Site | Concord | New Hampshire | 03301 | — |
| Research Site | Audubon | New Jersey | 08106 | — |
| Research Site | Flemington | New Jersey | 08822 | — |
| Research Site | Hackensack | New Jersey | 07601 | — |
| Research Site | Livingston | New Jersey | 07039 | — |
| Research Site | New Brunswick | New Jersey | 08903 | — |
| Research Site | Newark | New Jersey | 07103 | — |
| Research Site | Stratford | New Jersey | 08084 | — |
| Research Site | Toms River | New Jersey | 08755 | — |
| Research Site | West Long Branch | New Jersey | 07764 | — |
| Research Site | Albany | New York | 12206 | — |
| Research Site | Cedarhurst | New York | 11516 | — |
| Research Site | East Meadow | New York | 11554 | — |
| Research Site | Kingston | New York | 12401 | — |
| Research Site | New York | New York | 10016 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | Patchogue | New York | 11772 | — |
| Research Site | Plainview | New York | 11803 | — |
| Research Site | Syracuse | New York | 13202 | — |
| Research Site | Syracuse | New York | 13210 | — |
| Research Site | Asheville | North Carolina | 28803 | — |
| Research Sites | Charlotte | North Carolina | 28204 | — |
| Research Site | Charlotte | North Carolina | 28226 | — |
| Research Site | Greensboro | North Carolina | 27405 | — |
| Research Site | Hendersonville | North Carolina | 28792 | — |
| Research Site | Pinehurst | North Carolina | 28370 | — |
| Research Site | Raleigh | North Carolina | 27607 | — |
| Research Sites | Wilmington | North Carolina | 28401 | — |
| Research Site | Winston-Salem | North Carolina | 27157 | — |
| Research Site | Bismarck | North Dakota | 58501 | — |
| Research Site | Canton | Ohio | 44735 | — |
| Research Site | Centerville | Ohio | 45459 | — |
| Research Site | Cincinnati | Ohio | 45267 | — |
| Research Site | Cleveland | Ohio | 44195 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Oklahoma City | Oklahoma | 73104 | — |
| Research Site | Tulsa | Oklahoma | 74136 | — |
| Research Site | Portland | Oregon | 97225 | — |
| Research Site | Portland | Oregon | 97239 | — |
| Research Site | Abington | Pennsylvania | 19001 | — |
| Research Site | Allentown | Pennsylvania | 18103 | — |
| Research Site | Greensburg | Pennsylvania | 15601 | — |
| Research Site | Meadowbrook | Pennsylvania | 19046 | — |
| Research Site | Monroeville | Pennsylvania | 15146 | — |
| Research Site | Natrona Heights | Pennsylvania | 15065 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Pittsburgh | Pennsylvania | 15212 | — |
| Research Site | Columbia | South Carolina | 29203 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Spartanburg | South Carolina | 29307 | — |
| Research Site | Franklin | Tennessee | 37064 | — |
| Research Site | Knoxville | Tennessee | 37920 | — |
| Research Site | Knoxville | Tennessee | 37922 | — |
| Research Site | Nashville | Tennessee | 37205 | — |
| Research Site | Nashville | Tennessee | 37232 | — |
| Research Site | Arlington | Texas | 76012 | — |
| Research Site | Colleyville | Texas | 76034 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | Dallas | Texas | 75390 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Richmond | Virginia | 23298 | — |
| Research Site | Virginia Beach | Virginia | 23456 | — |
| Research Site | Kirkland | Washington | 98034 | — |
| Research Site | Seattle | Washington | 98101 | — |
| Research Site | Spokane | Washington | 99208 | — |
| Research Site | Tacoma | Washington | 98405 | — |
| Research Site | Tacoma | Washington | 98409 | — |
| Research Site | Green Bay | Wisconsin | 54301 | — |
| Research Site | Green Bay | Wisconsin | 54303 | — |
| Research Site | Green Bay | Wisconsin | 54308 | — |
| Research Site | Green Bay | Wisconsin | 54311 | — |
| Research Site | La Crosse | Wisconsin | 54601 | — |
| Research Site | Madison | Wisconsin | 53715 | — |
| Research Site | Milwaukee | Wisconsin | 53211 | — |
| Research Site | Milwaukee | Wisconsin | 53215 | — |
| Research Site | Neenah | Wisconsin | 54956 | — |
| Research Site | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 300 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02047097, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 24, 2023 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02047097 live on ClinicalTrials.gov.