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Completed No phase listed Observational

Dimethyl Fumarate (DMF) Observational Study

ClinicalTrials.gov ID: NCT02047097

Public ClinicalTrials.gov record NCT02047097. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 2, 2026, 10:01 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis (ESTEEM)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary objective of the study is to determine the incidence, type, and pattern of serious adverse events (SAEs), including but not limited to infections (including opportunistic infections), hepatic events, malignancies, and renal events, and of adverse events (AEs) leading to treatment discontinuation in patients with MS treated with dimethyl fumarate (DMF). Secondary objectives of this study in this population are as follows: To determine dimethyl fumarate (DMF) prescription and utilization patterns in routine clinical practice in patients with multiple sclerosis (MS); To assess the effectiveness of dimethyl fumarate (DMF) on multiple sclerosis (MS) disease activity and disability progression in routine clinical practice as determined by the Expanded Disability Status Scale (EDSS) score and multiple sclerosis (MS) relapse information; and To assess the effect of dimethyl fumarate (DMF) on health-related quality of life, healthcare resource consumption, and work productivity.

Study identification

NCT ID
NCT02047097
Recruitment status
Completed
Study type
Observational
Phase
Not listed
Lead sponsor
Biogen
Industry
Enrollment
5,487 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 18, 2013
Primary completion
Oct 30, 2022
Completion
Oct 30, 2022
Last update posted
May 23, 2023

2013 – 2022

United States locations

U.S. sites
168
U.S. states
40
U.S. cities
143
Facility City State ZIP Site status
Research Site Birmingham Alabama 35209
Research Site Huntsville Alabama 35801
Research Site Gilbert Arizona 85234
Research Site Phoenix Arizona 85006
Research Site Phoenix Arizona 85018
Research Site Phoenix Arizona 85048
Research Site Scottsdale Arizona 85251
Research Site Tucson Arizona 85718
Research Sites Fullerton California 92835
Research Site Hanford California 93230
Research Site Loma Linda California 92354
Research Site Los Angeles California 90015
Research Site Los Angeles California 90048
Research Site Newport Beach California 92663
Research Site San Francisco California 94158
Research Site Santa Ana California 92704
Research Site Aurora Colorado 80045
Research Site Colorado Springs Colorado 80907
Research Site Denver Colorado 80210
Research Site Fort Collins Colorado 80528
Research Site Danbury Connecticut 06810
Research Site Derby Connecticut 06418
Research Site Hartford Connecticut 06112
Research Site Norwich Connecticut 06360
Research Site Dover Delaware 19901
Research Site Wilmington Delaware 19801
Research Site Washington D.C. District of Columbia 20007
Research Site Washington D.C. District of Columbia 20037
Research Sites Boca Raton Florida 33486
Research Site Gainesville Florida 32610
Research Site Jacksonville Florida 32216
Research Sites Lighthouse PT Florida 33064
Research Site Maitland Florida 32751
Research Site Miami Florida 33125
Research Site Port Charlotte Florida 33952
Research Site Sarasota Florida 34233
Research Site St. Petersburg Florida 33710
Research Site St. Petersburg Florida 33713
Research Site Tampa Florida 33606
Research Sites Atlanta Georgia 30309
Research Site Atlanta Georgia 30309
Research Site Atlanta Georgia 30327
Research Site Augusta Georgia 30912
Research Site Columbus Georgia 31909
Research Site Savannah Georgia 31406
Research Site Chicago Illinois 60611
Research Site Chicago Illinois 60637
Research Site Evanston Illinois 60201
Research Site Herrin Illinois 62948
Research Site Peoria Illinois 61603
Research Site Winfield Illinois 60190
Research Site Elkhart Indiana 46514
Research Site Indianapolis Indiana 46202
Research Site Des Moines Iowa 50309
Research Site Des Moines Iowa 50314
Research Site Waterloo Iowa 50702
Research Site Overland Park Kansas 66211
Research Site Overland Park Kansas 66212
Research Site Henderson Kentucky 42420
Research Site Louisville Kentucky 40207
Research Site Hammond Louisiana 70403
Research Site New Orleans Louisiana 70121
Research Site Rockport Maine 04856
Research Site Baltimore Maryland 21201
Research Site Baltimore Maryland 21287
Research Site Bethesda Maryland 20814
Research Site Cumberland Maryland 21502
Research Site Glen Burnie Maryland 21061
Research Site Boston Massachusetts 02111
Research Site Boston Massachusetts 02135
Research Site Foxborough Massachusetts 02035
Research Site Jamaica Plain Massachusetts 02130
Research Site Lexington Massachusetts 02421
Research Site Wellesley Massachusetts 02481
Research Site Worcester Massachusetts 01655
Research Site Ann Arbor Michigan 48109
Research Site East Lansing Michigan 48824
Research Site Farmington Hills Michigan 48334
Research Site West Bloomfield Michigan 48322
Research Site Edina Minnesota 55435
Research Sites Minneapolis Minnesota 55407
Research Site Ocean Springs Mississippi 39564
Research Site Springfield Missouri 65806
Research Site St Louis Missouri 63110
Research Site Billings Montana 59101
Research Site Great Falls Montana 59405
Research Sites Lincoln Nebraska 68506
Research Site Lincoln Nebraska 68521
Research Site Wahoo Nebraska 68066
Research Site Las Vegas Nevada 89106
Research Site Concord New Hampshire 03301
Research Site Audubon New Jersey 08106
Research Site Flemington New Jersey 08822
Research Site Hackensack New Jersey 07601
Research Site Livingston New Jersey 07039
Research Site New Brunswick New Jersey 08903
Research Site Newark New Jersey 07103
Research Site Stratford New Jersey 08084
Research Site Toms River New Jersey 08755
Research Site West Long Branch New Jersey 07764
Research Site Albany New York 12206
Research Site Cedarhurst New York 11516
Research Site East Meadow New York 11554
Research Site Kingston New York 12401
Research Site New York New York 10016
Research Site New York New York 10029
Research Site Patchogue New York 11772
Research Site Plainview New York 11803
Research Site Syracuse New York 13202
Research Site Syracuse New York 13210
Research Site Asheville North Carolina 28803
Research Sites Charlotte North Carolina 28204
Research Site Charlotte North Carolina 28226
Research Site Greensboro North Carolina 27405
Research Site Hendersonville North Carolina 28792
Research Site Pinehurst North Carolina 28370
Research Site Raleigh North Carolina 27607
Research Sites Wilmington North Carolina 28401
Research Site Winston-Salem North Carolina 27157
Research Site Bismarck North Dakota 58501
Research Site Canton Ohio 44735
Research Site Centerville Ohio 45459
Research Site Cincinnati Ohio 45267
Research Site Cleveland Ohio 44195
Research Site Columbus Ohio 43210
Research Site Oklahoma City Oklahoma 73104
Research Site Tulsa Oklahoma 74136
Research Site Portland Oregon 97225
Research Site Portland Oregon 97239
Research Site Abington Pennsylvania 19001
Research Site Allentown Pennsylvania 18103
Research Site Greensburg Pennsylvania 15601
Research Site Meadowbrook Pennsylvania 19046
Research Site Monroeville Pennsylvania 15146
Research Site Natrona Heights Pennsylvania 15065
Research Site Philadelphia Pennsylvania 19107
Research Site Pittsburgh Pennsylvania 15212
Research Site Columbia South Carolina 29203
Research Site Greenville South Carolina 29605
Research Site Spartanburg South Carolina 29307
Research Site Franklin Tennessee 37064
Research Site Knoxville Tennessee 37920
Research Site Knoxville Tennessee 37922
Research Site Nashville Tennessee 37205
Research Site Nashville Tennessee 37232
Research Site Arlington Texas 76012
Research Site Colleyville Texas 76034
Research Site Dallas Texas 75246
Research Site Dallas Texas 75390
Research Site Houston Texas 77030
Research Site Norfolk Virginia 23502
Research Site Richmond Virginia 23298
Research Site Virginia Beach Virginia 23456
Research Site Kirkland Washington 98034
Research Site Seattle Washington 98101
Research Site Spokane Washington 99208
Research Site Tacoma Washington 98405
Research Site Tacoma Washington 98409
Research Site Green Bay Wisconsin 54301
Research Site Green Bay Wisconsin 54303
Research Site Green Bay Wisconsin 54308
Research Site Green Bay Wisconsin 54311
Research Site La Crosse Wisconsin 54601
Research Site Madison Wisconsin 53715
Research Site Milwaukee Wisconsin 53211
Research Site Milwaukee Wisconsin 53215
Research Site Neenah Wisconsin 54956
Research Site Waukesha Wisconsin 53188

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 300 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02047097, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 23, 2023 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT02047097 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →