An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Adults With Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT02049138. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Study, Multicenter, Open-Label Extension (OLE) Study in Rheumatoid Arthritis Subjects Who Have Completed a Preceding Phase 2 Randomized Controlled Trial (RCT) With Upadacitinib (ABT-494)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib in adults with rheumatoid arthritis (RA) who have completed a preceding randomized controlled trial with upadacitinib.
Study identification
- NCT ID
- NCT02049138
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 493 participants
Conditions and interventions
Conditions
Interventions
- Upadacitinib Drug
- Pneumococcal 13-valent conjugate vaccine (PCV-13) Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2014 (Actual)
- Primary completion
- Jul 29, 2021 (Actual)
- Completion
- Jul 29, 2021 (Actual)
- Last update posted
- Jul 12, 2022
2014 – 2021
United States locations
- U.S. sites
- 52
- U.S. states
- 22
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheum Assoc of North Alabama /ID# 135926 | Huntsville | Alabama | 35801 | — |
| AZ Arthritis and Rheumotology Research, PLLC /ID# 135902 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheumotology Research, PLLC /ID# 135931 | Phoenix | Arizona | 85032-9306 | — |
| C.V. Mehta MD, Med Corporation /ID# 124092 | Hemet | California | 92543 | — |
| Moores Cancer Center at UC San Diego /ID# 128747 | La Jolla | California | 92093 | — |
| Desert Medical Advances - Palm Desert /ID# 135911 | Palm Desert | California | 92260 | — |
| Orrin Troum, M.D. and Medical /ID# 135933 | Santa Monica | California | 90404 | — |
| Duplicate_Robin K. Dore MD, Inc /ID# 135906 | Tustin | California | 92780 | — |
| Inland Rheum Clin Trials Inc. /ID# 136716 | Upland | California | 91786 | — |
| Duplicate_Desert Valley Medical Group /ID# 135932 | Victorville | California | 92395 | — |
| Denver Arthritis Clinic /ID# 135901 | Denver | Colorado | 80230 | — |
| New England Research Associates, LLC /ID# 124085 | Bridgeport | Connecticut | 06606-1827 | — |
| Arthritis & Rheumatic Disease Specialties /ID# 135910 | Aventura | Florida | 33180 | — |
| Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 124082 | Boca Raton | Florida | 33486 | — |
| Omega Research Maitland, LLC /ID# 124094 | DeBary | Florida | 32713-2260 | — |
| University of Florida /ID# 124087 | Jacksonville | Florida | 32209 | — |
| Suncoast Research Group /ID# 137774 | Miami | Florida | 33135 | — |
| Omega Research Maitland, LLC /ID# 137398 | Orlando | Florida | 32808 | — |
| Millennium Research /ID# 135917 | Ormond Beach | Florida | 32174 | — |
| Arthritis Center, Inc. /ID# 124090 | Palm Harbor | Florida | 34684 | — |
| IRIS Research and Development, LLC /ID# 140362 | Plantation | Florida | 33324 | — |
| Lovelace Scientific Resources /ID# 128745 | Venice | Florida | 34292 | — |
| North Georgia Rheumatology Group /ID# 128746 | Lawrenceville | Georgia | 30045 | — |
| Kansas City Internal Medicine /ID# 135916 | Overland Park | Kansas | 66209 | — |
| PRN Professional Research Network of Kansas, LLC /ID# 124091 | Wichita | Kansas | 67205 | — |
| Klein and Associates MD - Hagerstown /ID# 124086 | Hagerstown | Maryland | 21742 | — |
| The Center for Rheumatology and Bone Research /ID# 124077 | Wheaton | Maryland | 20902 | — |
| Clinical Pharmacology Study Group /ID# 124079 | Worcester | Massachusetts | 01605 | — |
| June DO, PC /ID# 124081 | Lansing | Michigan | 48910 | — |
| Summit Medical Group /ID# 124076 | Clifton | New Jersey | 07012-1647 | — |
| Arthritis and Osteoporosis Associates /ID# 135907 | Freehold | New Jersey | 07728-8307 | — |
| Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 135913 | Voorhees Township | New Jersey | 08043 | — |
| Arthritis and Osteo Assoc /ID# 132280 | Las Cruces | New Mexico | 88011 | — |
| DJL Clinical Research, PLLC /ID# 131936 | Charlotte | North Carolina | 28210-8508 | — |
| Cincinnati Rheumatic Disease Study Group, Inc. /ID# 135921 | Cincinnati | Ohio | 45242-4468 | — |
| STAT Research, Inc. /ID# 134906 | Vandalia | Ohio | 45377-9464 | — |
| Health Research of Oklahoma /ID# 135904 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Duplicate_East Penn Rheumatology Assoc /ID# 135920 | Bethlehem | Pennsylvania | 18015 | — |
| Altoona Ctr Clinical Res /ID# 124089 | Duncansville | Pennsylvania | 16635 | — |
| Emkey Arthritis and Osteoporosis Clinic /ID# 135908 | Wyomissing | Pennsylvania | 19610 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 124080 | Summerville | South Carolina | 29486-7887 | — |
| Dr. Ramesh Gupta /ID# 128744 | Memphis | Tennessee | 38119 | — |
| Austin Rheumatology Research /ID# 124083 | Austin | Texas | 78705 | — |
| Accurate Clinical Management /ID# 128751 | Baytown | Texas | 77521 | — |
| Accurate Clinical Management /ID# 128752 | Houston | Texas | 77004 | — |
| Baylor College of Medicine - Baylor Medical Center /ID# 135905 | Houston | Texas | 77030-3411 | — |
| Houston Institute for Clin Res /ID# 135912 | Houston | Texas | 77074 | — |
| Accurate Clinical Research /ID# 128753 | Houston | Texas | 77089 | — |
| Accurate Clinical Research /ID# 128754 | Houston | Texas | 77089 | — |
| SW Rheumatology Res. LLC /ID# 135927 | Mesquite | Texas | 75150 | — |
| Mountain State Clinical Research /ID# 124088 | Clarksburg | West Virginia | 26301 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 135922 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 72 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02049138, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 12, 2022 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02049138 live on ClinicalTrials.gov.