ClinicalTrials.gov record
A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke
ClinicalTrials.gov ID: NCT02072226
Public ClinicalTrials.gov record NCT02072226. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IIIB, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Alteplase in Patients With Mild Stroke: Rapidly Improving Symptoms and Minor Neurologic Deficits (PRISMS)
Study identification
- NCT ID
- NCT02072226
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Genentech, Inc.
- Industry
- Enrollment
- 313 participants
Conditions and interventions
Conditions
Interventions
- Alteplase Drug
- Alteplase Placebo Drug
- Aspirin Drug
- Aspirin Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 30, 2014
- Primary completion
- Mar 21, 2017
- Completion
- Mar 21, 2017
- Last update posted
- Jul 2, 2018
2014 – 2017
United States locations
- U.S. sites
- 88
- U.S. states
- 31
- U.S. cities
- 75
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3300 | — |
| Banner Good Samaritan Medical Center | Phoenix | Arizona | 85006 | — |
| University of Arizona | Tucson | Arizona | 85724-5030 | — |
| St. Jude Medical Center | Fullerton | California | 92835 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Hoag Memorial Hospital | Newport Beach | California | 92658 | — |
| University of California Los Angeles | Santa Monica | California | 90404 | — |
| Colorado Neurological Institute | Englewood | Colorado | 80113 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Medical Center of The Rockies | Loveland | Colorado | 80538 | — |
| Associated Neurologists PC | Danbury | Connecticut | 06810 | — |
| Associated Neurologists of Southern CT PC | Fairfield | Connecticut | 06824 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Christiana Care Health Services; Sponsor Programs Ammon Education Center | Newark | Delaware | 19718-0002 | — |
| Nova Clinical Research, LLC | Bradenton | Florida | 34209 | — |
| Neurologic Consultants, P.A. | Fort Lauderdale | Florida | 33308 | — |
| University of Miami Miller School of Medicine; Clinical Reseach Building | Miami | Florida | 33136 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612-3244 | — |
| Alexian Brothers Neuroscience Institute | Elk Grove Village | Illinois | 60007 | — |
| Parkview Research Center | Fort Wayne | Indiana | 46845 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| St. Elizabeth Edgewood; Cancer Care Center" for Account St. Elizabeth Edgewood | Edgewood | Kentucky | 41017 | — |
| University of Louisville | Elizabethtown | Kentucky | 42791 | — |
| St. Elizabeth Florence | Florence | Kentucky | 41042 | — |
| St. Elizabeth Fort Thomas | Fort Thomas | Kentucky | 41075 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Northwest Hospital Center | Randallstown | Maryland | 21133 | — |
| Detroit Receiving Hospital | Detroit | Michigan | 48201 | — |
| Sparrow Health System | Lansing | Michigan | 48909 | — |
| St Joesph Mercy Hospital Oakland | Pontiac | Michigan | 48341 | — |
| Beaumont Hospital | Royal Oak | Michigan | 48073 | — |
| The Minneapolis Clinic of Neurology | Golden Valley | Minnesota | 55422 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Missouri Health Care | Columbia | Missouri | 65212 | — |
| Washington University | St Louis | Missouri | 63128 | — |
| Renown Health; Renown Institute for Neurosciences | Reno | Nevada | 89502 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Overlook Hospital | Summit | New Jersey | 07902 | — |
| Shore Neurology | Toms River | New Jersey | 08755 | — |
| SUNY Downstate Medical Center. | Brooklyn | New York | 11203 | — |
| Lutheran Medical Center | Brooklyn | New York | 11220 | — |
| Buffalo General Medical Center | Buffalo | New York | 14203 | — |
| Ichan School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of North Carolina At Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Guilford Neurologic Associates | Greensboro | North Carolina | 27401 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| University of Cincinnati | Cincinnati | Ohio | 45203-0542 | — |
| West Hospital | Cincinnati | Ohio | 45211 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Jewish Hospital | Cincinnati | Ohio | 45236 | — |
| Anderson Hospital | Cincinnati | Ohio | 45255 | — |
| Case Western Reserve University | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Wright State University | Dayton | Ohio | 45409 | — |
| Fairfield Hospital | Fairfield | Ohio | 45014 | — |
| University of Toledo Medical Center | Toledo | Ohio | 43614 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent's Medical Center | Portland | Oregon | 97225 | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | 18105 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Albert Einstein Healthcare Network | Philadelphia | Pennsylvania | 19141 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15219 | — |
| York Hospital | York | Pennsylvania | 17403 | — |
| Medical University of South Carolina; MSC 300 | Charleston | South Carolina | 29425 | — |
| University of South Carolina School of Medicine | Columbia | South Carolina | 29203-7606 | — |
| The Neurology And Pain Clinic | Orangeburg | South Carolina | 29118 | — |
| Chattanooga Center for Neurologic Research | Chattanooga | Tennessee | 37404 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Valley Baptist Medical Center | Harlingen | Texas | 78550 | — |
| Methodist Neurological Institute | Houston | Texas | 77030 | — |
| University Of Texas Health Science Center Houston | Houston | Texas | 77030 | — |
| Texas Tech Univ Health Sci Ctr | Lubbock | Texas | 79430 | — |
| University Hospital San Antonio | San Antonio | Texas | 78229 | — |
| University Of Utah | Salt Lake City | Utah | 84108 | — |
| Inova Fairfax Hospital | Fairfax | Virginia | 22031 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | — |
| Gunderson Health System | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02072226, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 2, 2018 · Synced Jun 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02072226 live on ClinicalTrials.gov.