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Completed Phase 3 Interventional Results available

A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD)

ClinicalTrials.gov ID: NCT02085135

Public ClinicalTrials.gov record NCT02085135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 3, 2026, 5:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-blind Study to Evaluate the Safety and Tolerability of Two Titration Schedules for ALKS 5461 for the Adjunctive Treatment of Major Depressive Disorder in Adults With an Inadequate Response to Antidepressant Therapy (the FORWARD-1 Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a Phase 3 study designed to evaluate the safety and tolerability of two titration schedules for ALKS 5461.

Study identification

NCT ID
NCT02085135
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
Alkermes, Inc.
Industry
Enrollment
66 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years to 70 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 31, 2014
Primary completion
Aug 31, 2014
Completion
Aug 31, 2014
Last update posted
Aug 13, 2019

2014

United States locations

U.S. sites
8
U.S. states
7
U.S. cities
8
Facility City State ZIP Site status
Alkermes Investigational Site Jacksonville Florida 32256
Alkermes Investigational Site Orlando Florida 32806
Alkermes Investigational Site Atlanta Georgia 30308
Alkermes Investigational Site Saint Charles Missouri 63304
Alkermes Investigational Site Staten Island New York 10305
Alkermes Investigational Site Dayton Ohio 45417
Alkermes Investigational Site Allentown Pennsylvania 18104
Alkermes Investigational Site Bellevue Washington 98007

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02085135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 13, 2019 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT02085135 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →