ClinicalTrials.gov record
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
ClinicalTrials.gov ID: NCT02089217
Public ClinicalTrials.gov record NCT02089217. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
Study identification
- NCT ID
- NCT02089217
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 2,486 participants
Conditions and interventions
Conditions
Interventions
- Carotid endarterectomy (CEA) Procedure
- Carotid Stenting (CAS) Device
- Intensive Medical Management - no CEA Other
- Intensive Medical Management - no CAS Other
Procedure · Device · Other
Eligibility (public fields only)
- Age range
- 35 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2014 (Actual)
- Primary completion
- Sep 12, 2025 (Actual)
- Completion
- Sep 12, 2025 (Actual)
- Last update posted
- Oct 1, 2025
2014 – 2025
United States locations
- U.S. sites
- 154
- U.S. states
- 40
- U.S. cities
- 115
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Huntsville Hospital/ Heart Center Research Alabama | Huntsville | Alabama | 35801 | — |
| Banner University Medical Center | Phoenix | Arizona | 85006 | — |
| St. Joseph's Hospital and Medical Center/Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Abrazo Arizona Heart Hospital | Phoenix | Arizona | 85016 | — |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| HonorHealth Scottsdale Osborn Medical Center | Scottsdale | Arizona | 85251 | — |
| Banner University Medical Center | Tucson | Arizona | 85724 | — |
| Central Arkansas Veteran's Healthcare System | Little Rock | Arkansas | 72143 | — |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | — |
| Mission Cardiovascular Research | Fremont | California | 94538 | — |
| University of California Irvine | Irvine | California | 92868 | — |
| UC San Diego Health | La Jolla | California | 92037 | — |
| Kaiser Permanente Los Angeles | Los Angeles | California | 90027 | — |
| Keck Medical Center of University of Southern California | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Los Angeles (UCLA) | Los Angeles | California | 90095 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| Kaiser Permanente | San Diego | California | 92116 | — |
| Kaiser Permanente Northern California | San Francisco | California | 94115 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| San Francisco VA Medical Center | San Francisco | California | 94121 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| St. Joseph's Medical Center | Stockton | California | 95204 | — |
| Providence Little Company of Mary Medical Center | Torrance | California | 90503 | — |
| St. Mary's Hospital Regional Medical Center | Grand Junction | Colorado | 81501 | — |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06520 | — |
| Medstar/Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| University of Florida Health at Shands | Gainesville | Florida | 32610 | — |
| Lyerly Neurosurgery | Jacksonville | Florida | 32207 | — |
| UF Jacksonville | Jacksonville | Florida | 32209 | — |
| First Coast Cardiovascular Institute | Jacksonville | Florida | 32216 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| Miami Cardiac and Vascular Institute at Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| Mount Sinai Medical Center of Florida | Miami Beach | Florida | 33140 | — |
| Cardiovascular Institute of Northwest Florida | Panama City | Florida | 32401 | — |
| Tallahassee Neurological Clinic | Tallahassee | Florida | 32308 | — |
| Tampa General/University of South Florida | Tampa | Florida | 33606 | — |
| Atlanta VA Medical Center | Atlanta | Georgia | 30033 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Southern Illinois Healthcare | Carbondale | Illinois | 62901 | — |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Northshore University | Evanston | Illinois | 60201 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Mercy Health Riverside | Rockford | Illinois | 61114 | — |
| Prairie Heart/St. John's Hospital | Springfield | Illinois | 62701 | — |
| Franciscan St. Francis Health | Indianapolis | Indiana | 46237 | — |
| Deaconess Heart Group | Newburgh | Indiana | 47630 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| University of Kentucky Hospital | Lexington | Kentucky | 40536 | — |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| Tulane University Heart and Vascular | New Orleans | Louisiana | 70112 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| University of Maryland VA | Baltimore | Maryland | 21201 | — |
| Johns Hopkins Medical Institution | Baltimore | Maryland | 21224 | — |
| White Oak Medical Center | Takoma Park | Maryland | 20912 | — |
| St. Elizabeth's Medical Center | Boston | Massachusetts | 02135 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02144 | — |
| Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | — |
| University of Massachusetts Memorial Hospital | Worcester | Massachusetts | 01605 | — |
| VA Ann Arbor Healthcare System | Ann Arbor | Michigan | 48105 | — |
| University of Michigan Hospital and Health Systems | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Michigan Vascular Center/McLaren- Flint | Flint | Michigan | 48532 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Cardiac and Vascular Research Center of Northern Michigan/McLaren Northern Michigan | Petoskey | Michigan | 49770 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073 | — |
| Trinity Health/Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| Minneapolis Clinic of Neurology, Ltd./North Memorial Medical Center | Golden Valley | Minnesota | 55422 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| St. Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Cox Medical Center | Springfield | Missouri | 65807 | — |
| Mercy Medical Research Institute | Springfield | Missouri | 65807 | — |
| John Cochran VA Medical Center | St Louis | Missouri | 63106 | — |
| Mercy Hospital | St Louis | Missouri | 63141 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Cooper University | Camden | New Jersey | 08103 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| SUNY Buffalo | Buffalo | New York | 14203 | — |
| The Feinstein Institute of Medical Research/Northwell Health | Manhasset | New York | 11030 | — |
| Mount Sinai Hospital New York | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| St. Francis Hospital | Roslyn | New York | 11576 | — |
| Stony Brook University | Stony Brook | New York | 11794 | — |
| Crouse Hospital | Syracuse | New York | 13210 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| North Carolina Heart & Vascular Research | Raleigh | North Carolina | 27607 | — |
| Coastal Carolina Surgical Associates PA | Wilmington | North Carolina | 28401 | — |
| Novant Health/Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Health | Fargo | North Dakota | 58104 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Good Samaritan Hospital | Cincinnati | Ohio | 45220 | — |
| Louis Stokes Cleveland VA Medical Center | Cleveland | Ohio | 44106 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Ohio State Medical Center | Columbia | Ohio | 43210 | — |
| OhioHealth Research Institute | Columbus | Ohio | 43214 | — |
| Jobst Vascular Institute/University of Toledo | Toledo | Ohio | 43606 | — |
| Mercy Health St. Vincent Medical Center | Toledo | Ohio | 43608 | — |
| St. John Clinical Research Institute | Tulsa | Oklahoma | 74104 | — |
| Providence Brain and Spine Institute | Portland | Oregon | 97225 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Lehigh Valley Hospital - Network Office of Research | Allentown | Pennsylvania | 18103 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| Doylestown Hospital | Doylestown | Pennsylvania | 18901 | — |
| UPMC Hamot | Erie | Pennsylvania | 16550 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC Presbyterian University Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| VA Pittsburgh Healthcare | Pittsburgh | Pennsylvania | 15240 | — |
| Pinnacle Health Cardiovascular Institute | Wormleysburg | Pennsylvania | 17043 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Berks Cardiologists / St. Joseph's Medical Center | Wyomissing | Pennsylvania | 19610 | — |
| The Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| North Central Heart Institute | Sioux Falls | South Dakota | 57108 | — |
| CVA Heart Institute | Kingsport | Tennessee | 37660 | — |
| Tennova Healthcare/ Turkey Creek Medical Center | Knoxville | Tennessee | 37934 | — |
| Baptist Memorial Hospital | Memphis | Tennessee | 38017 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Seton Medical Center Austin | Austin | Texas | 78705 | — |
| Cardiothoracic and Vascular Surgeons | Austin | Texas | 78756 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75235 | — |
| Valley Baptist Medical Center | Harlingen | Texas | 78551 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Memorial Hermann Texas Medical Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Hospitals and Clinics | Salt Lake City | Utah | 84132 | — |
| George E. Wahlen Department of Veterans Affairs Medical Center | Salt Lake City | Utah | 84148 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Inova Fairfax Health Care | Falls Church | Virginia | 22042 | — |
| Winchester Medical Center | Winchester | Virginia | 22601 | — |
| Overlake Hospital | Bellevue | Washington | 98004 | — |
| University of Washington Medicine-Harborview Medical Center | Seattle | Washington | 98104 | — |
| VA Puget Sound Health Care System | Seattle | Washington | 98108 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
| West Virginia University | Morgantown | West Virginia | 26554 | — |
| Gundersen Clinic, Ltd | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Hospitals & Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02089217, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02089217 live on ClinicalTrials.gov.