Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer

ClinicalTrials.gov ID: NCT02124681

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Current options to treat insulin resistance in diabetes are fairly limited. For this reason, novel treatments would represent a major progress. The generic drug hydroxychloroquine (HCQ) has poorly understood effects on blood sugar metabolism. In this study, the investigators will examine the mechanisms by which this drug affects glucose metabolism and which cells are affected. Findings emanating from this project will help establish whether HCQ may be a viable treatment for disorders of glucose metabolism.

Study identification

NCT ID: NCT02124681
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1
Lead sponsor: University of Pittsburgh; Other
Enrollment: 34 participants

Conditions and interventions

Conditions

Insulin Resistance

Interventions

Hydroxychloroquine Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 21 Years to 69 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 2014 (Type not available)
Primary completion: Aug 2016 (Actual)
Completion: Aug 2016 (Actual)
Last update posted: Jun 6, 2017

2014 – 2016

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
UPMC Montefiore Hospital	Pittsburgh	Pennsylvania	15234	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02124681, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 6, 2017 · Synced Nov 15, 2026