ClinicalTrials.gov record
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
ClinicalTrials.gov ID: NCT02135042
Public ClinicalTrials.gov record NCT02135042. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed, if there is no detectable EBV DNA in their plasma, then patients are randomized to either standard adjuvant cisplatin and fluorouracil chemotherapy or observation. If there is still detectable levels of plasma EBV DNA, patients will be randomized to standard cisplatin and fluorouracil chemotherapy versus gemcitabine and paclitaxel. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, fluorouracil, gemcitabine hydrochloride, and paclitaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cisplatin and fluorouracil is more effective than gemcitabine hydrochloride and paclitaxel after radiation therapy in treating patients with nasopharyngeal cancer.
Study identification
- NCT ID
- NCT02135042
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 924 participants
Conditions and interventions
Conditions
Interventions
- Bone Scan Procedure
- Cisplatin Drug
- Clinical Observation Other
- Computed Tomography Procedure
- Fluorouracil Drug
- Gemcitabine Hydrochloride Drug
- Intensity-Modulated Radiation Therapy Radiation
- Laboratory Biomarker Analysis Other
- Magnetic Resonance Imaging Procedure
- Paclitaxel Drug
- Positron Emission Tomography Procedure
- Quality-of-Life Assessment Other
Procedure · Drug · Other + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2014
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Aug 27, 2026
2014 – 2026
United States locations
- U.S. sites
- 197
- U.S. states
- 34
- U.S. cities
- 153
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| The Kirklin Clinic at Acton Road | Birmingham | Alabama | 35243 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Mills-Peninsula Medical Center | Burlingame | California | 94010 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Kaiser Permanente Dublin | Dublin | California | 94568 | — |
| Fresno Cancer Center | Fresno | California | 93720 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Palo Alto Medical Foundation Health Care | Palo Alto | California | 94301 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | — |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| South Sacramento Cancer Center | Sacramento | California | 95823 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| UCSF Medical Center-Mount Zion | San Francisco | California | 94115 | — |
| UCSF Medical Center-Mission Bay | San Francisco | California | 94158 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| City of Hope South Pasadena | South Pasadena | California | 91030 | — |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | — |
| Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | 94086 | — |
| Lutheran Hospital - Cancer Centers of Colorado | Golden | Colorado | 80401 | — |
| Banner North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| Banner North Colorado Medical Center - Loveland Campus | Loveland | Colorado | 80539 | — |
| AdventHealth Parker | Parker | Colorado | 80138 | — |
| Intermountain Health Lutheran Hospital | Wheat Ridge | Colorado | 80401 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Emory Proton Therapy Center | Atlanta | Georgia | 30308 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | — |
| The Cancer Center of Hawaii-Pali Momi | ‘Aiea | Hawaii | 96701 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | 48183 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| McLaren Cancer Institute-Clarkston | Clarkston | Michigan | 48346 | — |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | 48038 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Singh and Arora Hematology Oncology PC | Flint | Michigan | 48532 | — |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | — |
| Mid-Michigan Physicians-Lansing | Lansing | Michigan | 48912 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| McLaren-Port Huron | Port Huron | Michigan | 48060 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Minnesota Oncology - Burnsville | Burnsville | Minnesota | 55337 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| Phelps Health Delbert Day Cancer Institute | Rolla | Missouri | 65401 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | 89106 | — |
| Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | 89119 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Saint Mary's Regional Medical Center | Reno | Nevada | 89503 | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07101 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Maimonides Medical Center | Brooklyn | New York | 11219 | — |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| New York Proton Center | New York | New York | 10035 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Memorial Sloan Kettering Sleepy Hollow | Sleepy Hollow | New York | 10591 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| Geauga Hospital | Chardon | Ohio | 44024 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | 44906 | — |
| North Coast Cancer Care | Sandusky | Ohio | 44870 | — |
| Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | 44136 | — |
| ProMedica Flower Hospital | Sylvania | Ohio | 43560 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | 44691 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | — |
| Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | 17901 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | 29316 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | — |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Riverton Hospital | Riverton | Utah | 84065 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| Saint George Regional Medical Center | St. George | Utah | 84770 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Naval Medical Center - Portsmouth | Portsmouth | Virginia | 23708-2197 | — |
| Legacy Salmon Creek Hospital | Vancouver | Washington | 98686 | — |
| Aspirus Cancer Care-Antigo-Volm Cancer Center | Antigo | Wisconsin | 54409 | — |
| HSHS Sacred Heart Hospital | Eau Claire | Wisconsin | 54701 | — |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | — |
| Marshfield Medical Center | Marshfield | Wisconsin | 54449 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | — |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | — |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | — |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | — |
| Aspirus Cancer Care-Wausau | Wausau | Wisconsin | 54401 | — |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02135042, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02135042 live on ClinicalTrials.gov.