TOPIC Trial for COPD

ClinicalTrials.gov ID: NCT02135432

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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT02135432. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.

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All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Placebo Controlled Pilot Study to Determine the Safety and Efficacy of Ivacaftor (VX-770) for the Treatment of Chronic Obstructive Pulmonary Disease (The TOPIC Trial)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The study is a randomized, double-blind, placebo-controlled, multiple-dose, pilot study of orally-administered ivacaftor in subjects with chronic obstructive pulmonary disease. Subjects will be administered the study drug ivacaftor 150 mg (or placebo) twice daily (BID).

Study identification

NCT ID: NCT02135432
Recruitment status: Completed
Study type: Interventional
Phase: Early Phase 1
Lead sponsor: University of Alabama at Birmingham; Other
Enrollment: 12 participants

Conditions and interventions

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Ivacaftor Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 40 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 2015 (Type not available)
Primary completion: Oct 2015 (Actual)
Completion: Nov 2015 (Actual)
Last update posted: Feb 24, 2017

2015

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02135432, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 24, 2017 · Synced Nov 12, 2026