Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
Public ClinicalTrials.gov record NCT02143648. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Parallel, 3-Arm Study of the Safety and Anti-Pruritic Efficacy of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objectives of the study to evaluate the effects of two doses of nalbuphine HCl ER tablets on the change from baseline in the worst itch Numerical Rating Scale (NRS) in hemodialysis patients with moderate to severe uremic pruritus and to evaluate the safety and tolerability in the study population.
Study identification
- NCT ID
- NCT02143648
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 373 participants
Conditions and interventions
Conditions
Interventions
- nalbuphine HCl ER tablets 60 mg BID Drug
- nalbuphine HCl ER tablets 120mg BID Drug
- Placebo tablets BID Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2014 (Type not available)
- Primary completion
- Jul 2015 (Actual)
- Completion
- Jul 2015 (Actual)
- Last update posted
- May 21, 2025
2014 – 2015
United States locations
- U.S. sites
- 41
- U.S. states
- 22
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Nephrology Associates PC | Birmingham | Alabama | 35211 | — |
| University South Alabama Medical Center | Mobile | Alabama | 63317 | — |
| Arizona Kidney Disease and Hypertension Center | Phoenix | Arizona | 85012 | — |
| U.S. Renal Care Inc | Pine Bluff | Arkansas | 76103 | — |
| North America Research Institute | Azusa | California | 91702 | — |
| Pegasus Dialysis, LLC | Bakersfield | California | 93308 | — |
| Central Nephrology Medical Group | Bakersfield | California | 93309 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Mark Lee MD, Inc | Whittier | California | 90606 | — |
| Nephrology and Hypertension Associates PC | Middlebury | Connecticut | 06762 | — |
| DaVita Inc Clinical Research Unit | Stamford | Connecticut | 06902 | — |
| Nephrology Center DBA Paragon Health | Miami | Florida | 33162 | — |
| Pines Clinical Research Inc | Pembroke Pines | Florida | 33028 | — |
| Genesis Clinical Research | Tampa | Florida | 33614 | — |
| DaVita Central Orlando Dialysis | Winter Park | Florida | 32789 | — |
| Southwest Georgia Nephrology Clinic PC | Albany | Georgia | 31701 | — |
| Renal Physicians of Georgia | Macon | Georgia | 31217 | — |
| Pacific Renal Research Institute | Meridian | Idaho | 83642 | — |
| Fresenius Medical Care of Evergreen Park | Evergreen Park | Illinois | 60805 | — |
| Western New England Renal and Transplant Association | Springfield | Massachusetts | 01107 | — |
| McComb Limited Care Facility | McComb | Mississippi | 39648 | — |
| Kidney Associates of Kansas City PC | Kansas City | Missouri | 64131 | — |
| Nephrology-Hypertension Associates of Central New Jersey PA | North Brunswick | New Jersey | 80902 | — |
| Renal Medicine Associates | Albuquerque | New Mexico | 87109 | — |
| Newtown Dialysis Center, Inc | College Point | New York | 11356 | — |
| DaVita Northtown's Dialysis Center | Tonawanda | New York | 14150 | — |
| Durham Nephrology Associates | Durham | North Carolina | 27704 | — |
| Wake Nephrology Associates PA | Raleigh | North Carolina | 27609 | — |
| Brookview Hills Research Associates LLC | Winston-Salem | North Carolina | 27103 | — |
| University Of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Nephrology Research Consortium | Bethlehem | Pennsylvania | 18017 | — |
| Delaware Valley Nephrology | Philadelphia | Pennsylvania | 19118 | — |
| Dialysis Clinic Inc. | Philadelphia | Pennsylvania | 19129 | — |
| South Carolina Nephrology and Hypertension | Hampton | South Carolina | 29924 | — |
| South Carolina Nephrology and Hypertension | Orangeburg | South Carolina | 29118 | — |
| Carolina Diabetes and Kidney Center | Sumter | South Carolina | 29150 | — |
| Southwest Renal Research Institute | Chattanooga | Tennessee | 37408 | — |
| U.S. Renal Care Inc | Fort Worth | Texas | 76105 | — |
| U.S Renal Care Inc. | Fort Worth | Texas | 76164 | — |
| U.S. Renal Care Inc. | Mansfield | Texas | 76063 | — |
| Fresenius Medical Care Shorewood | Shorewood | Wisconsin | 53211 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02143648, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 21, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02143648 live on ClinicalTrials.gov.