Study of Azacitidine With or Without Birinapant in Subjects With MDS or CMMoL
Public ClinicalTrials.gov record NCT02147873. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Azacitidine With or Without Birinapant With a Single Arm Open-Label Run-In Phase in Subjects With Higher Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized double blind placebo controlled study of azacitidine with or without birinapant in subjects with higher risk Myelodysplastic syndrome, secondary MDS or myelomonocytic leukemia (CMMoL) who are naïve, to azacitidine therapy. Pre-clinical and mechanistic studies support that azacitidine may modulate pathways that enable birinapant-mediated anti-tumor activity.
Study identification
- NCT ID
- NCT02147873
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 118 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2014 (Type not available)
- Primary completion
- Jan 2016 (Actual)
- Completion
- Jun 2016 (Actual)
- Last update posted
- Oct 20, 2016
2014 – 2016
United States locations
- U.S. sites
- 46
- U.S. states
- 24
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Palo Verde Hematology Oncology | Glendale | Arizona | 85304 | — |
| Arizona Center for Cancer Care | Glendale | Arizona | 85306 | — |
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| Arizona Oncology Associates | Tucson | Arizona | 85704 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| North County Oncology | Oceanside | California | 92056 | — |
| Desert Hematology Oncology Medical Group | Rancho Mirage | California | 92270 | — |
| Stanford Hospital and Clinics | Stanford | California | 94305 | — |
| Wellness Oncology & Hematology | West Hills | California | 91307 | — |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32207 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | — |
| Hematology Oncology Associates of the Treasure Coast | Port Saint Lucie | Florida | 34952 | — |
| H. Lee Moffitt Cancer Center & Research Institute | Tampa | Florida | 33612 | — |
| Bond Clinic PA | Winter Haven | Florida | 33880 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Simmons Cancer Institute at Southern Illinois University | Springfield | Illinois | 62794 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Louisville Hospital/James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| University of Maryland, Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| University of Massachusetts Worcester | Worcester | Massachusetts | 01655 | — |
| St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| North Shore Hematology Oncology Associates | East Setauket | New York | 11733 | — |
| Monter Cancer Center | Lake Success | New York | 11042 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Weill Cornell Medical College - New York-Presbyterian Hospital | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Gabrail Cancer Center Research | Canton | Ohio | 44718 | — |
| Oncology Hematology Care, Inc. | Cincinnati | Ohio | 45242 | — |
| Oregon Health and Sciences University | Portland | Oregon | 97239 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Medical University of South Carolina, Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Carolina Blood and Cancer Care Associates, P.A. | Rock Hill | South Carolina | 29732 | — |
| Tennessee Oncology | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Tyler Hematology Oncology PA | Tyler | Texas | 75701 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| University of Utah, Huntsman Cancer Hospital | Salt Lake City | Utah | 84112 | — |
| Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02147873, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2016 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02147873 live on ClinicalTrials.gov.