ClinicalTrials.gov record
Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease
ClinicalTrials.gov ID: NCT02177786
Public ClinicalTrials.gov record NCT02177786. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Double-Blind, Placebo-Controlled, Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GS-4997 in Subjects With Diabetic Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to determine the effect of selonsertib (formerly GS-4997) on estimated glomerular filtration rate (eGFR) decline in participants with diabetic kidney disease (DKD). Participants will be randomized with a 1:1:1:1 allocation to receive 1 of 3 doses of selonsertib (2 mg, 6 mg, or 18 mg) or matching placebo.
Study identification
- NCT ID
- NCT02177786
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 334 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2014 (Type not available)
- Primary completion
- Jul 2016 (Actual)
- Completion
- Aug 2016 (Actual)
- Last update posted
- Nov 5, 2019
2014 – 2016
United States locations
- U.S. sites
- 100
- U.S. states
- 30
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Alabama at Birmingham (UAB) | Birmingham | Alabama | 35294 | — |
| Chase Medcare | Huntsville | Alabama | 35811 | — |
| Choice Medicine | Toney | Alabama | 35773 | — |
| Akdhc Medical Research Services, Llc | Peoria | Arizona | 85381 | — |
| Akdhc Medical Research Services, Llc | Phoenix | Arizona | 85012 | — |
| Akdhc Medical Research Services, Llc | Phoenix | Arizona | 85027 | — |
| Akdhc Medical Research Services, Llc | Prescott | Arizona | 86301 | — |
| Robert J. Bloomberg, MD | Tempe | Arizona | 85283 | — |
| AKDHC East Office | Tucson | Arizona | 85712 | — |
| Clinical Research Connections, LLC | Harrisburg | Arkansas | 72432 | — |
| North America Research Institute | Azusa | California | 91702 | — |
| California Institute of Renal Research | Chula Vista | California | 91910 | — |
| California Institute of Renal Research Inc. | El Centro | California | 92243 | — |
| Renal Consultants Medical Group Granada Hills | Granada Hills | California | 91344 | — |
| Torrance Clinical Research | Lomita | California | 90717 | — |
| IMD Medical Group | Los Angeles | California | 90020 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Kidney Research Center | Lynwood | California | 90262 | — |
| Apex Research of Riverside | Riverside | California | 92505 | — |
| San Francisco General Hospital | San Francisco | California | 94110 | — |
| Clearview Medical Research, LLC | Santa Clarita | California | 91350 | — |
| American Institute of Research | Whittier | California | 90603 | — |
| Omega Research Consultants | DeBary | Florida | 32713 | — |
| Creekside Medical Research | DeLand | Florida | 32720 | — |
| Riverside Clinical Research | Edgewater | Florida | 32132 | — |
| ASA Clinical Research | Jupiter | Florida | 33458 | — |
| FPA Clinical Research | Kissimmee | Florida | 34741 | — |
| The Chappel Group LLC | Kissimmee | Florida | 34741 | — |
| South Florida Research Institute | Lauderdale Lakes | Florida | 33313 | — |
| Prestige Clinical Research Center Inc | Miami | Florida | 33133 | — |
| International Physicians Research / Nephrology Associates of South Miami | Miami | Florida | 33173 | — |
| Tellus Clinical Research, Inc | Miami | Florida | 33173 | — |
| Coral Research Clinic Corp | Miami | Florida | 33175 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Discovery Medical Research Group | Ocala | Florida | 34471 | — |
| Central Florida Internists | Orlando | Florida | 32811 | — |
| Sunset Point Medical Associates DBA | Palm Harbor | Florida | 34684 | — |
| Pines Clinical Research Inc. | Pembroke Pines | Florida | 33028 | — |
| Central Florida Internists | Saint Cloud | Florida | 34769 | — |
| Florida Pulmonary Research Institute | Winter Park | Florida | 32789 | — |
| Rockdale Medical Research Associates | Conyers | Georgia | 30094 | — |
| John H. Stroger Jr. Hospital Of Cook County | Chicago | Illinois | 60612 | — |
| Midwest Endocrinology | Crystal Lake | Illinois | 60012 | — |
| Beacon Medical Group Kidney and Hypertension Center | Mishawaka | Indiana | 46544 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Hutchinson Clinic, P.A | Hutchinson | Kansas | 67502 | — |
| Kansas Nephrology Research Institute, LLC | Wichita | Kansas | 67214 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Four Rivers Clinical Research | Paducah | Kentucky | 42003 | — |
| Research Nurse Specialists, LLc | Lafayette | Louisiana | 70503 | — |
| Crescent City Clinical Research Center | Metairie | Louisiana | 70006 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Internal Medicine Specialists | New Orleans | Louisiana | 70115 | — |
| Green Clinic LLC | Ruston | Louisiana | 71270 | — |
| Northwest Louisiana Nephrology | Shreveport | Louisiana | 71101 | — |
| Southern Clinical Research | Zachary | Louisiana | 70791 | — |
| Johns Hopkins Hospital/University | Baltimore | Maryland | 21205 | — |
| A. Kaldun Nossuli MD Research | Bethesda | Maryland | 20814 | — |
| Wayne State University | Detroit | Michigan | 48201 | — |
| Apex Medical Research.Com | Flint | Michigan | 48504 | — |
| Elite Clinical Research | Flint | Michigan | 48532 | — |
| Troy Internal Medicine, PC | Troy | Michigan | 48098 | — |
| VA Medical Center | Kansas City | Missouri | 64128 | — |
| Mercury Street Medical Group, PLLC, Big Sky Clinical Research, LLC | Butte | Montana | 59701 | — |
| Alegent Creighton Health | Omaha | Nebraska | 68131 | — |
| Creighton Diabetes Center | Omaha | Nebraska | 68131 | — |
| Nephrology and Hypertension Associates of New Jersey | Voorhees Township | New Jersey | 08043 | — |
| Albuquerque Clinical Trials | Albuquerque | New Mexico | 87102 | — |
| Nephrology Associates, PC | Flushing | New York | 11355 | — |
| Mountain Kidney and Hypertension Associates | Asheville | North Carolina | 28801 | — |
| Boice-Willis Clinic | Rocky Mount | North Carolina | 27804 | — |
| Carolina Research Center | Shelby | North Carolina | 28150 | — |
| Hightop Medical Research Center | Cincinnati | Ohio | 45231 | — |
| Craig S Thompson MD LLC | Marion | Ohio | 43302 | — |
| Your Diabetes Endocrine Nutrition Group Inc | Mentor | Ohio | 44060 | — |
| Chris Sholer, MD, PC | Oklahoma City | Oklahoma | 73116 | — |
| Bend Memorial Clinic | Bend | Oregon | 97701 | — |
| Southeast Renal Research Institute | Chattanooga | Tennessee | 37408 | — |
| Knoxville Kidney Center | Knoxville | Tennessee | 37923 | — |
| Arlington Nephrology | Arlington | Texas | 76015 | — |
| MW Clinical Research Center | Beaumont | Texas | 77701 | — |
| Padre Coast Clinical Research | Corpus Christi | Texas | 78404 | — |
| Corsicana Medical Research, PLLC | Corsicana | Texas | 75110 | — |
| Texas Tech Univ. Health Sciences Center | El Paso | Texas | 79905 | — |
| TVC Clinical Research | Gonzales | Texas | 78629 | — |
| Diagnostic Clinic of Houston | Houston | Texas | 77004 | — |
| Mercury Clinical Research | Houston | Texas | 77036 | — |
| Lakewood Family Practice | Houston | Texas | 77070 | — |
| Southwest Clinical Trials | Houston | Texas | 77074 | — |
| Southwest Houston Research, Ltd. | Houston | Texas | 77099 | — |
| HMRI CCAT Pearland | Pearland | Texas | 77584 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78215 | — |
| Briggs Clinical Research, LLC | San Antonio | Texas | 78224 | — |
| San Antonio Kidney Disease Center Physicians Group, P.L.L.C. | San Antonio | Texas | 78229 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Val R. Hansen, M.D. | Bountiful | Utah | 84010 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| University of Wisconsin | Madison | Wisconsin | 53713 | — |
| Zablocki VAMC | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02177786, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2019 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02177786 live on ClinicalTrials.gov.