ClinicalTrials.gov record
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov ID: NCT02179086
Public ClinicalTrials.gov record NCT02179086. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 9, 2026, 11:50 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma
Study identification
- NCT ID
- NCT02179086
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 606 participants
Conditions and interventions
Conditions
Interventions
- 3-Dimensional Conformal Radiation Therapy Radiation
- Intensity-Modulated Radiation Therapy Radiation
- Laboratory Biomarker Analysis Other
- Photon Beam Radiation Therapy Radiation
- Proton Beam Radiation Therapy Radiation
- Quality-of-Life Assessment Other
- Questionnaire Administration Other
- Temozolomide Drug
Radiation · Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 3, 2014
- Primary completion
- Jul 6, 2025
- Completion
- Dec 30, 2026
- Last update posted
- Jan 13, 2026
2014 – 2026
United States locations
- U.S. sites
- 230
- U.S. states
- 42
- U.S. cities
- 182
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| Arizona Oncology Associates-West Orange Grove | Tucson | Arizona | 85704 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California | 93301 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Fresno Cancer Center | Fresno | California | 93720 | — |
| Marin General Hospital | Greenbrae | California | 94904 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Palo Alto Medical Foundation Health Care | Palo Alto | California | 94301 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | — |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| South Sacramento Cancer Center | Sacramento | California | 95823 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California | 95065 | — |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | — |
| Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | 94086 | — |
| John Muir Medical Center-Walnut Creek | Walnut Creek | California | 94598 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| UF Health Cancer Institute - Gainesville | Gainesville | Florida | 32610 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| University of Florida Health Science Center - Jacksonville | Jacksonville | Florida | 32209 | — |
| Baptist Medical Center South | Jacksonville | Florida | 32258 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Emory Proton Therapy Center | Atlanta | Georgia | 30308 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Rush MD Anderson Cancer Center | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Radiation Oncology Associates PC | Fort Wayne | Indiana | 46804 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| Parkview Regional Medical Center | Fort Wayne | Indiana | 46845 | — |
| IU Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Community Cancer Center East | Indianapolis | Indiana | 46219 | — |
| Community Cancer Center South | Indianapolis | Indiana | 46227 | — |
| Community Cancer Center North | Indianapolis | Indiana | 46256 | — |
| IU Health Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | — |
| Norton Hospital Pavilion and Medical Campus | Louisville | Kentucky | 40202 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| Willis-Knighton Medical and Cancer Center | Shreveport | Louisiana | 71103 | — |
| Maryland Proton Treatment Center | Baltimore | Maryland | 21201 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | 21044 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Mass General/North Shore Cancer Center | Danvers | Massachusetts | 01923 | — |
| Lowell General Hospital | Lowell | Massachusetts | 01854 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| McLaren Cancer Institute-Owosso | Owosso | Michigan | 48867 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Saint Luke's Hospital of Duluth | Duluth | Minnesota | 55805 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| University of Kansas Cancer Center - North | Kansas City | Missouri | 64154 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Saint Mary's Regional Medical Center | Reno | Nevada | 89503 | — |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire | 03756 | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Capital Health Medical Center-Hopewell | Pennington | New Jersey | 08534 | — |
| ProCure Proton Therapy Center-Somerset | Somerset | New Jersey | 08873 | — |
| Virtua Voorhees | Voorhees Township | New Jersey | 08043 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | — |
| Northwell Health/Center for Advanced Medicine | Lake Success | New York | 11042 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Mission Hospital | Asheville | North Carolina | 28801 | — |
| Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Geauga Hospital | Chardon | Ohio | 44024 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Cleveland Clinic Cancer Center Independence | Independence | Ohio | 44131 | — |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | 44130 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| North Coast Cancer Care | Sandusky | Ohio | 44870 | — |
| UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | 44136 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | 44691 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Willamette Valley Cancer Center | Eugene | Oregon | 97401 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | — |
| Sechler Family Cancer Center | Lebanon | Pennsylvania | 17042 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | 19114 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| WellSpan Health-York Cancer Center | York | Pennsylvania | 17403 | — |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | 29316 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | — |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | — |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | — |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| Tennessee Cancer Specialists-Dowell Springs | Knoxville | Tennessee | 37909 | — |
| Dell Seton Medical Center at The University of Texas | Austin | Texas | 78701 | — |
| Austin Cancer Centers-Central Austin | Austin | Texas | 78702 | — |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Central Austin Cancer Center | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin Cancer Center | Austin | Texas | 78745 | — |
| Austin Cancer Centers-North | Austin | Texas | 78758 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| Texas Oncology - Denison Cancer Center | Denison | Texas | 75020 | — |
| Texas Oncology-Flower Mound | Flower Mound | Texas | 75028 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| Memorial Hermann Memorial City Medical Center | Houston | Texas | 77024 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| UTMB Cancer Center at Victory Lakes | League City | Texas | 77573 | — |
| Covenant Medical Center-Lakeside | Lubbock | Texas | 79410 | — |
| Texas Oncology-Seton Williamson | Round Rock | Texas | 78665 | — |
| Texas Oncology - Round Rock Cancer Center | Round Rock | Texas | 78681 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Texas Oncology Cancer Center Sugar Land | Sugar Land | Texas | 77479 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Saint George Regional Medical Center | St. George | Utah | 84770 | — |
| Central Vermont Medical Center/National Life Cancer Treatment | Berlin Corners | Vermont | 05602 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Dartmouth Cancer Center - North | Saint Johnsbury | Vermont | 05819 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| FHCC at Northwest Hospital | Seattle | Washington | 98133 | — |
| FHCC Proton Therapy Center | Seattle | Washington | 98133 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| Compass Oncology Vancouver | Vancouver | Washington | 98684 | — |
| Legacy Salmon Creek Hospital | Vancouver | Washington | 98686 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02179086, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 13, 2026 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02179086 live on ClinicalTrials.gov.