TIGER-1: Safety and Efficacy Study of Rociletinib (CO-1686) or Erlotinib in Patients With EGFR-mutant/Metastatic NSCLC Who Have Not Had Any Previous EGFR Directed Therapy
Public ClinicalTrials.gov record NCT02186301. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TIGER 1: A Randomized, Open-Label, Phase 2/3 Study of CO-1686 or Erlotinib as First-Line Treatment of Patients With EGFR-Mutant Advanced/Metastatic NSCLC
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the safety and anti-tumor effect of rociletinib with erlotinib in patients whose tumors have specific EGFR mutations and who have not previously received any treatment for advanced/metastatic EGFR mutated NSCLC. This study is a 'Randomized' Study. This means that upon entering the study, patients will be randomly assigned to be dosed with either rociletinib twice a day or erlotinib once a day. Patients will continue to take either rociletinib or erlotinib until it is no longer beneficial.
Study identification
- NCT ID
- NCT02186301
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2014 (Type not available)
- Primary completion
- Jun 28, 2017 (Actual)
- Completion
- Jun 28, 2017 (Actual)
- Last update posted
- May 7, 2019
2014 – 2017
United States locations
- U.S. sites
- 54
- U.S. states
- 21
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| East Valley Hematology and Oncology Medical Group, Inc. | Burbank | California | 91505 | — |
| City of Hope | Duarte | California | 91010 | — |
| Compassionate Cancer Care Medical Group, Inc. | Fountain Valley | California | 92708 | — |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835-3825 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093-0698 | — |
| University of Southern California, Norris Comprehensive Cancer Center | Los Angeles | California | 90089 | — |
| Sutter Medical Group | Sacramento | California | 95816 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| Sansum Clinic | Santa Barbara | California | 93105 | — |
| Central Coast Medical Oncology Corporation | Santa Maria | California | 93454 | — |
| UCLA Medical Center | Santa Monica | California | 90404 | — |
| The Oncology Institute of Hope and Innovation | Whittier | California | 90603 | — |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Cancer Specialists of North Florida | Fleming Island | Florida | 32003 | — |
| Florida Cancer Specialists and Research Institute | Fort Myers | Florida | 33916 | — |
| Advanced Medical Specialties | Miami | Florida | 33176 | — |
| Florida Hospital Cancer Institute | Orlando | Florida | 32804 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Illinois Cancer Center | Chicago | Illinois | 60612 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square | Baltimore | Maryland | 21237 | — |
| Walter Reed Army Institute of Research | Bethesda | Maryland | 20889 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Oncology Hematology West PC | Omaha | Nebraska | 68130 | — |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89014 | — |
| Regional Cancer Care Associates, LLC | East Brunswick | New Jersey | 08816 | — |
| Regional Cancer Care Associates | Morristown | New Jersey | 07962 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| USC/Norris Comprehensive Cancer Center | Nashville | Tennessee | 37212-3505 | — |
| Texas Oncology, PA | Austin | Texas | 78745 | — |
| Texas Oncology-Beaumont | Beaumont | Texas | 77702 | — |
| Texas Oncology, P.A. | Bedford | Texas | 76022 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8852 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| The University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Oncology-Plano East | Plano | Texas | 75075-7753 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| University of Washington | Seattle | Washington | 98109 | — |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | — |
| Yakima Valley Memorial Hospital, North Star Lodge | Yakima | Washington | 98902 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02186301, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2019 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02186301 live on ClinicalTrials.gov.