ClinicalTrials.gov record
Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer
ClinicalTrials.gov ID: NCT02186847
Public ClinicalTrials.gov record NCT02186847. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 18, 2026, 4:57 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC
Study identification
- NCT ID
- NCT02186847
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 170 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Metformin Drug
- Paclitaxel Drug
- Radiation Therapy Radiation
Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2014
- Primary completion
- Apr 15, 2019
- Completion
- Sep 3, 2025
- Last update posted
- Oct 8, 2025
2014 – 2025
United States locations
- U.S. sites
- 220
- U.S. states
- 42
- U.S. cities
- 180
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lewis and Faye Manderson Cancer Center | Tuscaloosa | Alabama | 35401 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | — |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | — |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| South Sacramento Cancer Center | Sacramento | California | 95823 | — |
| UCSF Medical Center-Mount Zion | San Francisco | California | 94115 | — |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | — |
| Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | 95687 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| McKee Medical Center | Loveland | Colorado | 80539 | — |
| SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | 80033 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| UF Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| 21st Century Oncology-Palatka | Palatka | Florida | 32177 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Dekalb Medical Center | Decatur | Georgia | 30033 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | — |
| The Cancer Center of Hawaii-Pali Momi | ‘Aiea | Hawaii | 96701 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Kootenai Cancer Center | Post Falls | Idaho | 83854 | — |
| Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | 83301 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| IU Health Bloomington | Bloomington | Indiana | 47403 | — |
| Radiation Oncology Associates PC | Fort Wayne | Indiana | 46804 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| Franciscan Health Indianapolis | Indianapolis | Indiana | 46237 | — |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Hardin Memorial Hospital | Elizabethtown | Kentucky | 42701 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | — |
| Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | 70809 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | 70809 | — |
| Mary Bird Perkins Cancer Center - Covington | Covington | Louisiana | 70433 | — |
| Mary Bird Perkins Cancer Center - Houma | Houma | Louisiana | 70360 | — |
| Maine Medical Center- Scarborough Campus | Scarborough | Maine | 04074 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| Peninsula Regional Medical Center | Salisbury | Maryland | 21801 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lowell General Hospital | Lowell | Massachusetts | 01854 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| Mercy Health Mercy Campus | Muskegon | Michigan | 49444 | — |
| McLaren Cancer Institute-Owosso | Owosso | Michigan | 48867 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | — |
| Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | 49085 | — |
| William Beaumont Hospital - Troy | Troy | Michigan | 48085 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Saint Luke's Hospital of Duluth | Duluth | Minnesota | 55805 | — |
| Fairview-Southdale Hospital | Edina | Minnesota | 55435 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| The University of Kansas Cancer Center-South | Kansas City | Missouri | 64131 | — |
| The University of Kansas Cancer Center-North | Kansas City | Missouri | 64154 | — |
| The University of Kansas Cancer Center-Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | 65401 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Community Medical Hospital | Missoula | Montana | 59804 | — |
| CHI Health Saint Francis | Grand Island | Nebraska | 68803 | — |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Wentworth-Douglass Hospital | Dover | New Hampshire | 03820 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Virtua Memorial | Mount Holly | New Jersey | 08060 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| Virtua Voorhees | Voorhees Township | New Jersey | 08043 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | 87109 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Gaston Hematology and Oncology Associates-Belmont | Belmont | North Carolina | 28012 | — |
| CaroMont Regional Medical Center | Gastonia | North Carolina | 28054 | — |
| Gaston Hematology and Oncology Associates | Gastonia | North Carolina | 28054 | — |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | 28374 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Mercy Medical Center | Canton | Ohio | 44708 | — |
| Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Geauga Hospital | Chardon | Ohio | 44024 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Cleveland Clinic Cancer Center Independence | Independence | Ohio | 44131 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | 44130 | — |
| Newark Radiation Oncology | Newark | Ohio | 43055 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| North Coast Cancer Care | Sandusky | Ohio | 44870 | — |
| UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | 44136 | — |
| University Pointe | West Chester | Ohio | 45069 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | 44691 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| The Regional Cancer Center | Erie | Pennsylvania | 16505 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | 29605 | — |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | 29615 | — |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | — |
| Greenville Health System Cancer Institute-Greer | Greer | South Carolina | 29650 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | 29672 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | 29307 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| The Methodist Hospital System | Houston | Texas | 77030 | — |
| MD Anderson in Katy | Houston | Texas | 77094 | — |
| UTMB Cancer Center at Victory Lakes | League City | Texas | 77573 | — |
| MD Anderson League City | Nassau Bay | Texas | 77058 | — |
| MD Anderson in Sugar Land | Sugar Land | Texas | 77478 | — |
| MD Anderson in The Woodlands | The Woodlands | Texas | 77384 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Central Vermont Medical Center/National Life Cancer Treatment | Berlin Corners | Vermont | 05602 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | 05819 | — |
| Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia | 22939 | — |
| Harrison Medical Center | Bremerton | Washington | 98310 | — |
| PeaceHealth Saint John Medical Center | Longview | Washington | 98632 | — |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | — |
| Community Memorial Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin | 53097 | — |
| Ascension Columbia Saint Mary's Water Tower Medical Commons | Milwaukee | Wisconsin | 53211 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Zablocki Veterans Administration Medical Center | Milwaukee | Wisconsin | 53295 | — |
| Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | 54548 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | — |
| Saint Michael's Hospital | Stevens Point | Wisconsin | 54481 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
| The Alyce and Elmore Kraemer Cancer Care Center | West Bend | Wisconsin | 53095 | — |
| Diagnostic and Treatment Center | Weston | Wisconsin | 54476 | — |
| Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02186847, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2025 · Synced May 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02186847 live on ClinicalTrials.gov.