An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With Methotrexate
Public ClinicalTrials.gov record NCT02187055. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b/4 Randomized Double Blind Study Of 5 Mg Of Tofacitinib With And Without Methotrexate In Comparison To Adalimumab With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid Arthritis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To assess the efficacy of tofacitinib monotherapy or tofacitinib with methotrexate as compared to adalimumab with methotrexate. To compare the efficacy of tofacitinib monotherapy compared to tofacitinib combined with methotrexate. To compare effects on all health outcomes measures in the study. To evaluate the safety and tolerability of tofacitinib and adalimumab. To evaluate the safety of the zoster vaccine given prior to the initiation of tofacitinb or adalimumab.
Study identification
- NCT ID
- NCT02187055
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,152 participants
Conditions and interventions
Conditions
Interventions
- Tofacitinib with methotrexate Drug
- Tofacitinib without methotrexate Drug
- Adalimumab with methotrexate Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2014 (Actual)
- Primary completion
- Dec 2016 (Actual)
- Completion
- Dec 2016 (Actual)
- Last update posted
- Jun 27, 2018
2014 – 2016
United States locations
- U.S. sites
- 60
- U.S. states
- 22
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheumatology Associates of North Alabama, PC | Huntsville | Alabama | 35801 | — |
| Arthrocare, Arthritis Care & Research, PC | Gilbert | Arizona | 85234 | — |
| Medvin Clinical Research | Covina | California | 91722 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| HealthCare Partners Medical Group | Huntington Beach | California | 92646 | — |
| Keck Medicine of USC - Division of Rheumatology | Los Angeles | California | 90033 | — |
| University of Southern California (USC) Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Ronald Reagan UCLA Medical Center - Drug Information Center | Los Angeles | California | 90095 | — |
| UCLA David Geffen School of Medicine, Division of Rheumatology | Los Angeles | California | 90095 | — |
| Medvin Clinical Research | Placentia | California | 92870 | — |
| San Diego Arthritis Medical Clinic | San Diego | California | 92108 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Medvin Clinical Research | Van Nuys | California | 91405 | — |
| Medvin Clinical Research | Whittier | California | 90602 | — |
| Joao M. A. Nascimento | Bridgeport | Connecticut | 06606 | — |
| AARDS Research, Inc. | Aventura | Florida | 33180 | — |
| Arthritis and Rheumatic Disease Specialties | Aventura | Florida | 33180 | — |
| Riverside Clinical Research | Edgewater | Florida | 32132 | — |
| Centre for Rheumatology, Immunology and Arthritis | Fort Lauderdale | Florida | 33309 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Omega Research Consultants, LLC | Orlando | Florida | 32804 | — |
| Arthritis Center, Inc. | Palm Harbor | Florida | 34684 | — |
| Gulf Region Clinical Research Institute Llc | Pensacola | Florida | 32514 | — |
| West Broward Rheumatology Associates, Inc. | Tamarac | Florida | 33321 | — |
| BayCare Medical Group Inc | Tampa | Florida | 33614 | — |
| The Center for Arthritis and Rheumatism | Vero Beach | Florida | 32960 | — |
| The Office of Alastair C. Kennedy, MD | Vero Beach | Florida | 32960 | — |
| Advanced Clinical Research of Orlando, Inc. | Winter Garden | Florida | 34787 | — |
| Coeur D'Alene Arthritis Clinic | Coeur d'Alene | Idaho | 83814 | — |
| Institute of Arthritis Research | Idaho Falls | Idaho | 83404 | — |
| Deerbrook Medical Associates | Vernon Hills | Illinois | 60061 | — |
| Diagnostic Rheumatology and Research PC | Indianapolis | Indiana | 46227 | — |
| Ochsner Clinic Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Arthritis and Diabetes Clinic, Inc | Monroe | Louisiana | 71203 | — |
| Arthritis Treatment Center | Frederick | Maryland | 21702 | — |
| Jasper Clinic | Kalamazoo | Michigan | 49007 | — |
| Arthritis and Osteoporosis Treatment and Research Center | Flowood | Mississippi | 39232 | — |
| Clinvest/ A Division of Banyan Group, Inc. | Springfield | Missouri | 65807 | — |
| St. Louis Center For Clinical Research Barbara Caciolo, MD | St Louis | Missouri | 63128 | — |
| Dr. Prem C. Chatpar M.D.,LLC | Plainview | New York | 11803 | — |
| PMG Research of Salisbury, LLC | Salisbury | North Carolina | 28144 | — |
| Rowan Diagnostic Clinic | Salisbury | North Carolina | 28144 | — |
| PMG Research of Wilmington | Wilmington | North Carolina | 28401 | — |
| Trinity Health Center - Medical Arts | Minot | North Dakota | 58701 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Arthritis Group | Philadelphia | Pennsylvania | 19152-3303 | — |
| Low Country Rheumatology, PA | Charleston | South Carolina | 29406 | — |
| West Tennessee Research Institute | Jackson | Tennessee | 38305 | — |
| Accurate Clinical Management, LLC | Baytown | Texas | 77521 | — |
| Arthritis Care And Diagnostic Center, P.A. | Dallas | Texas | 75231 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| Accurate Clinical Management, LLC | Houston | Texas | 77004 | — |
| Rheumatology Clinic of Houston, PA | Houston | Texas | 77065 | — |
| Houston Institute For Clinical Research | Houston | Texas | 77074 | — |
| Arthritis & Osteoporosis Associates, LLP | Lubbock | Texas | 79424 | — |
| Southwest Rheumatology Research, LLC. | Mesquite | Texas | 75150 | — |
| Accurate Clinical Research, Inc. | San Antonio | Texas | 78229 | — |
| Arthritis & Osteoporosis Center of South Texas | San Antonio | Texas | 78232 | — |
| Arthritis Northwest, PLLC | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 155 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02187055, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2018 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02187055 live on ClinicalTrials.gov.