Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults
Public ClinicalTrials.gov record NCT02191579. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Prospective, Randomized, Open-label Study to Compare the Efficacy, Safety, and Tolerability of BOTOX® and Topiramate for Headache Prophylaxis in Adults With Chronic Migraine
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety and tolerability of prophylactic (preventative) treatment with BOTOX® (onabotulinumtoxinA) compared to topiramate in adults with chronic migraine.
Study identification
- NCT ID
- NCT02191579
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 282 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 5, 2014 (Actual)
- Primary completion
- May 9, 2017 (Actual)
- Completion
- Sep 1, 2017 (Actual)
- Last update posted
- Jun 7, 2018
2014 – 2017
United States locations
- U.S. sites
- 32
- U.S. states
- 17
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St Joseph's Hospital Barrow Neurology Clinics | Phoenix | Arizona | 85013 | — |
| North County Neurology Associates | Encinitas | California | 92024 | — |
| California Headache and Balance Center | Fresno | California | 93723 | — |
| Newport Beach Clinical Research Associates, Inc. | Newport Beach | California | 92663 | — |
| Denver Neurological Clinic | Denver | Colorado | 80210 | — |
| Ki Health Partners LLC DBA New England Institute for Neurology and Headache | Stamford | Connecticut | 06905 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton Inc | Boca Raton | Florida | 33486 | — |
| Design Neuroscience Center | Doral | Florida | 33172 | — |
| NW FL Clinical Research Group, LLC | Gulf Breeze | Florida | 32561 | — |
| Negroski, Sutherland & Hanes Neurology | Sarasota | Florida | 34239 | — |
| Neurology Research Institute at Palm Beach Neurology | West Palm Beach | Florida | 33407 | — |
| Robbins Headache Clinic | Riverwoods | Illinois | 60015 | — |
| International Clinical Research Institute Inc | Overland Park | Kansas | 66210 | — |
| Kansas City Bone and Joint Clinic | Overland Park | Kansas | 66211 | — |
| The NeuroMedical Center | Baton Rouge | Louisiana | 70810 | — |
| MedVadis Research Corporation | Watertown | Massachusetts | 02472 | — |
| New England Regional Headache Center Inc | Worcester | Massachusetts | 01605 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Clinvest | Springfield | Missouri | 65807 | — |
| Mercy Health Research | St Louis | Missouri | 63141 | — |
| Renown Institute for Neurosciences | Reno | Nevada | 89502 | — |
| Dent Neurosciences Research Center Incorporated | Amherst | New York | 14226 | — |
| Island Neurological Associates PC | Plainview | New York | 11803 | — |
| Montefiore Headache Center | The Bronx | New York | 10461 | — |
| Asheville Neurology Specialists PA | Asheville | North Carolina | 28806 | — |
| Headache Wellness Center | Greensboro | North Carolina | 27405 | — |
| Raleigh Neurology Associates PA | Raleigh | North Carolina | 27607 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Preferred Primary Care Physicians | Pittsburgh | Pennsylvania | 15236 | — |
| Main Line Health Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Texas Neurology | Dallas | Texas | 75214 | — |
| Puget Sound Neurology | Tacoma | Washington | 98409 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02191579, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 7, 2018 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02191579 live on ClinicalTrials.gov.