A Study of PF-06438179 (Infliximab-Pfizer) and Infliximab in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (REFLECTIONS B537-02).
Public ClinicalTrials.gov record NCT02222493. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-blind Study Assessing The Efficacy And Safety Of Pf-06438179 And Infliximab In Combination With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid Arthritis Who Have Had An Inadequate Response To Methotrexate
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will assess the efficacy and safety of PF-06438179 and infliximab in combination with methotrexate in subjects with active rheumatoid arthritis who have had an inadequate response to methotrexate.
Study identification
- NCT ID
- NCT02222493
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 650 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 26, 2014 (Actual)
- Primary completion
- Jun 29, 2016 (Actual)
- Completion
- Jun 1, 2017 (Actual)
- Last update posted
- May 30, 2018
2014 – 2017
United States locations
- U.S. sites
- 43
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Clinical and Translational Research Center of Alabama, PC | Tuscaloosa | Alabama | 35406 | — |
| Sun Valley Arthritis Center, Ltd. | Peoria | Arizona | 85381 | — |
| Arizona Arthritis & Rheumatology Associates, P.C. | Phoenix | Arizona | 85037 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Arthritis & Osteoporosis Medical Center | La Palma | California | 90623 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Desert Valley Medical Group | Victorville | California | 92395 | — |
| Javed Rheumatology Associates, Inc | Newark | Delaware | 19713 | — |
| Arthritis and Rheumatic Disease Specialties | Aventura | Florida | 33180 | — |
| International Medical Research | Daytona Beach | Florida | 32117 | — |
| Not listed | Daytona Beach | Florida | 32117 | — |
| San Marcus Research Clinic, Inc. | Miami | Florida | 33015 | — |
| Advance Medical Research Services Corporation | Miami | Florida | 33165 | — |
| Sarasota Arthritis Research Center | Sarasota | Florida | 34239 | — |
| Alastair C. Kennedy, MD | Vero Beach | Florida | 32960 | — |
| Indian River Primary Care | Vero Beach | Florida | 32960 | — |
| Harbin Clinic | Rome | Georgia | 30165 | — |
| Advanced Clinical Research | Meridian | Idaho | 83642 | — |
| Methodist Medical Center of IL | Peoria | Illinois | 61636 | — |
| Physician's Clinic of Iowa, P.C. | Cedar Rapids | Iowa | 52403 | — |
| Gilbert-Graves Clinic | Bowling Green | Kentucky | 42101 | — |
| Graves-Gilbert Clinic Bowling Green | Bowling Green | Kentucky | 42101 | — |
| Ochsner Clinic Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Arthritis and Diabetes Clinic, Inc. | Monroe | Louisiana | 71203 | — |
| The Center for Rheumatology and Bone Research | Wheaton | Maryland | 20902 | — |
| Western Michigan University Homer Stryker MD School of Medicine Center for Clinical Research | Battle Creek | Michigan | 49015 | — |
| Arthritis, Rheumatic & Back Disease Associates | Voorhees Township | New Jersey | 08043 | — |
| Trinity Health Center-Medical Arts | Minot | North Dakota | 58701 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research Center of Reading, LLC | Wyomissing | Pennsylvania | 19610 | — |
| Low Country Rheumatology, PA | Charleston | South Carolina | 29406 | — |
| Regional Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Regional Medical Clinic | Rapid City | South Dakota | 57701 | — |
| West Tennessee Research Institute | Jackson | Tennessee | 38305 | — |
| Ramesh C Gupta, MD | Memphis | Tennessee | 38119 | — |
| Austin Regional Clinic | Austin | Texas | 78731 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| Accurate Clinical Research, Inc. | Houston | Texas | 77034 | — |
| Accurate Clinical Research | Nassau Bay | Texas | 77058 | — |
| Pharmacy Services, Sentara Leigh Hospital | Norfolk | Virginia | 23502 | — |
| Sentara Medical Group, Clinical Research | Norfolk | Virginia | 23502 | — |
| The Seattle Arthritis Clinic | Seattle | Washington | 98133 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 141 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02222493, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 30, 2018 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02222493 live on ClinicalTrials.gov.