Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
Public ClinicalTrials.gov record NCT02225041. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will test for drug- and dose-dependent relationships between sedative exposure and neurocognitive outcomes along the early developmental spectrum and will control for baseline and environmental factors, as well as the severity and course of illness. Hypotheses: 1. Greater exposure to benzodiazepines and/or ketamine will be associated with lower IQ even when controlling for severity of illness, hospital course, and baseline factors. In addition, benzodiazepines and/or ketamine will negatively affect other aspects of neurocognitive function. 2. Younger children exposed to benzodiazepines and/or ketamine will have worse neurocognitive outcomes than older children with similar sedative exposure and severity of illness.
Study identification
- NCT ID
- NCT02225041
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 360 participants
Conditions and interventions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 30 Months to 13 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2014
- Primary completion
- Nov 30, 2018
- Completion
- Nov 30, 2018
- Last update posted
- Jun 17, 2019
2014 – 2018
United States locations
- U.S. sites
- 31
- U.S. states
- 20
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| University Medical Center, The University of Arizona | Tucson | Arizona | 85724 | — |
| Children's Hospital and Research Center at Oakland | Oakland | California | 94609-1809 | — |
| Children's Hospital of Orange County | Orange | California | 92868 | — |
| Lucile Salter Packard Children's Hospital at Stanford | Palo Alto | California | 94304-0126 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Children's Hospital at University of California San Francisco Medical Center | San Francisco | California | 94143 | — |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | — |
| Yale-New Haven Children's Hospital | New Haven | Connecticut | 06520-8064 | — |
| Nemours/Alfred I. duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Holtz Children's Hospital | Miami | Florida | 33136 | — |
| Florida Hospital for Children | Orlando | Florida | 32803 | — |
| Children's Memorial Hospital, Chicago | Chicago | Illinois | 60614-3363 | — |
| Advocate Hope Children's Hospital | Oak Lawn | Illinois | 60453 | — |
| University of Maryland Hospital for Children | Baltimore | Maryland | 21201-1595 | — |
| Johns Hopkins Children's Center | Baltimore | Maryland | 21287 | — |
| University of Massachusetts Memorial Children's Medical Center | Worcester | Massachusetts | 01655 | — |
| C. S. Mott Children's Hospital of the University of Michigan | Ann Arbor | Michigan | 48109-0243 | — |
| Children's Mercy Hospital, Kansas City | Kansas City | Missouri | 84108 | — |
| St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756-0001 | — |
| Cohen Children's Medical Center of New York | New Hyde Park | New York | 11040 | — |
| The Children's Hospital at Montefiore | The Bronx | New York | 10467 | — |
| Duke Children's Hospital and Health Center | Durham | North Carolina | 27710 | — |
| Doernbecher Children's Hospital | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Monroe Carell, Jr. Children's Hospital at Vanderbilt | Nashville | Tennessee | 37232-9075 | — |
| Medical City Children's Hospital | Dallas | Texas | 75230 | — |
| Children's Medical Center Dallas | Dallas | Texas | 75235 | — |
| Primary Children's Medical Center | Salt Lake City | Utah | 84113 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02225041, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 17, 2019 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02225041 live on ClinicalTrials.gov.