Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
Public ClinicalTrials.gov record NCT02229929. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Pharmacokinetics of Intravenous CR845 in Hemodialysis Patients, and Its Safety and Efficacy in Hemodialysis Patients With Uremic Pruritus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to: * Evaluate the safety and pharmacokinetic profile of repeated doses IV CR845 over one week in patients who are undergoing hemodialysis. (Part A) * This study is also investigating whether repeated doses of IV CR845 over two weeks is safe and effective in reducing the intensity of itching in hemodialysis patients with uremic pruritus (Part B).
Study identification
- NCT ID
- NCT02229929
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 89 participants
Conditions and interventions
Conditions
Interventions
- Part A: Placebo Drug
- Part A: CR845 0.5 mcg/kg Drug
- Part A: CR845 1.0 mcg/kg Drug
- Part A: CR845 2.5 mcg/kg Drug
- Part B: Placebo Drug
- Part B: CR845 1.0 mcg/kg Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2014 (Type not available)
- Primary completion
- Jul 2015 (Actual)
- Completion
- Jul 2015 (Actual)
- Last update posted
- Aug 10, 2016
2014 – 2015
United States locations
- U.S. sites
- 20
- U.S. states
- 11
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| US Renal Care | Pine Bluff | Arkansas | 71603 | — |
| US Renal Care | Chula Vista | California | 91915 | — |
| US Renal Care | Long Beach | California | 90806 | — |
| Valley Renal Medical Group | Northridge | California | 91324 | — |
| Nephrology Specialists Medical Group, Inc | Orange | California | 92868 | — |
| North American Research Institute | San Dimas | California | 91773 | — |
| University of Florida College of Medicine Jacksonville | Jacksonville | Florida | 32209 | — |
| Orlando Clinical Research Center | Orlando | Florida | 32809 | — |
| Pines Clinical Research, Inc. | Pembroke Pines | Florida | 33028 | — |
| Emory Dialysis Center at Northside | Atlanta | Georgia | 30318 | — |
| Western New England Renal & Transplant Associates, PC | Springfield | Massachusetts | 01107 | — |
| US Renal Care | Gallup | New Mexico | 87301 | — |
| Trude Weishaupt Memorial Dialysis Center | Fresh Meadows | New York | 11365 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| Brookview Hills Research Associates, LLC | Winston-Salem | North Carolina | 27103 | — |
| US Renal Care | Aiken | South Carolina | 29803 | — |
| Southeast Renal Research Institute | Chattanooga | Tennessee | 37408 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| US Renal Care | Grand Prairie | Texas | 75050 | — |
| US Renal Care | San Antonio | Texas | 78202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02229929, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2016 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02229929 live on ClinicalTrials.gov.