Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure
Public ClinicalTrials.gov record NCT02235077. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Aldosterone Targeted Neurohormonal Combined With Natriuresis Therapy - HF (ATHENA-HF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to test the hypothesis that high-dose spironolactone will lead to greater proportional reduction in NT-proBNP levels from randomization to 96 hours over standard of care.
Study identification
- NCT ID
- NCT02235077
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 360 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 21 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 29, 2014
- Primary completion
- Apr 11, 2016
- Completion
- Jun 5, 2016
- Last update posted
- Jun 13, 2017
2014 – 2016
United States locations
- U.S. sites
- 22
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston VA Healtcare System | West Roxbury | Massachusetts | 02132 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63117 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Southeastern Regional Medical Center | Lumberton | North Carolina | 28358 | — |
| University Hospitals - Case Medical Center | Cleveland | Ohio | 44106 | — |
| Metro Health System | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17603 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Medical College | Philadelphia | Pennsylvania | 19107 | — |
| Michael Debakey VA Medical Center | Houston | Texas | 77030 | — |
| University of Utah School of Medicine | Salt Lake City | Utah | 84132 | — |
| Utah VA Medical Center | Salt Lake City | Utah | 84132 | — |
| The University of Vermont- Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02235077, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 13, 2017 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02235077 live on ClinicalTrials.gov.