A Dose-Escalation Study Evaluating the Combination of Trastuzumab Emtansine (T-DM1) With Neratinib in Women With Metastatic HER2-Positive Breast Cancer
Public ClinicalTrials.gov record NCT02236000. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase Ib/II Dose-Escalation Study Evaluating the Combination of Trastuzumab Emtansine (T-DM1) With Neratinib in Women With Metastatic HER2-Positive Breast Cancer
Study identification
- NCT ID
- NCT02236000
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- NSABP Foundation Inc
- Network
- Enrollment
- 49 participants
Conditions and interventions
Conditions
Interventions
- Neratinib Drug
- T-DM1 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2014
- Primary completion
- Nov 30, 2020
- Completion
- Jul 31, 2021
- Last update posted
- Jan 25, 2023
2014 – 2021
United States locations
- U.S. sites
- 15
- U.S. states
- 7
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cleveland Clinic Weston | Weston | Florida | 33331 | — |
| Cancer Care Specialists of Central Illinois | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Cancer Care Specialists of Central Illinois-Swansea | Swansea | Illinois | 62226 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Stephenson Cancer Center at the University of Oklahoma Health Services Center | Oklahoma City | Oklahoma | 73104 | — |
| UPMC- Hillman Cancer Center-Monroeville | Monroeville | Pennsylvania | 15146 | — |
| Alleheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Hillman Cancer Center | Pittsburgh | Pennsylvania | 15213 | — |
| Magee Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC- St. Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC Hillman Cancer Center North Hills at Passavant | Pittsburgh | Pennsylvania | 15237 | — |
| Women & Infants Hospital of Rhode Island | Providence | Rhode Island | 02905 | — |
| West Virginia University | Morgantown | West Virginia | 26501 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02236000, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 25, 2023 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02236000 live on ClinicalTrials.gov.