The COMBINE Study: The CKD Optimal Management With BInders and NicotinamidE
Public ClinicalTrials.gov record NCT02258074. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The COMBINE clinical trial is a pilot study evaluating the effects of nicotinamide and lanthanum carbonate on serum phosphate and fibroblast growth factor 23 (FGF23) in patients with Chronic Kidney Disease (CKD) stages 3-4.
Study identification
- NCT ID
- NCT02258074
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 205 participants
Conditions and interventions
Conditions
Interventions
- Nicotinamide Drug
- Lanthanum Carbonate Drug
- Placebo (for Nicotinamide) Drug
- Placebo (for lanthanum carbonate) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 2015
- Primary completion
- Oct 31, 2018
- Completion
- Aug 31, 2019
- Last update posted
- Aug 1, 2021
2015 – 2019
United States locations
- U.S. sites
- 7
- U.S. states
- 5
- U.S. cities
- 5
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California at San Diego | San Diego | California | 92161 | — |
| Denver Nephrology Research | Denver | Colorado | 80230 | — |
| George Washington University | Washington D.C. | District of Columbia | 20037 | — |
| NorthShore University Health System | Chicago | Illinois | 60201 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Utah | Salt Lake City | Utah | 84112 | — |
| Utah VA | Salt Lake City | Utah | 84112 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02258074, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 1, 2021 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02258074 live on ClinicalTrials.gov.