Study of Ticagrelor Versus Aspirin Treatment in Patients With Myocardial Injury Post Major Non-cardiac Surgery
Public ClinicalTrials.gov record NCT02291419. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open Label, Randomized Study to Determine the Rate of Cardiovascular Events at 1 yr for Patients With Elevated Troponins Post Major Non-cardiac Surgery and the Impact of Ticagrelor vs Aspirin on the Occurrence of Cardiovascular Events
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this pilot study is to establish the rate of cardiovascular events in patients with elevated troponins levels after major, non-cardiac surgery and to evaluate the efficacy and safety of FDA approved study drug (ticagrelor) compared to aspirin in these patients. Data from current studies suggest that myocardial injury detected by minor elevations in troponin levels within 3 days after non-cardiac surgery may occur in 10-24% of patients and is associated with an increased risk of mortality at 30 days and 1 year. There are no current guidelines for care of patients with elevated troponin levels in the absence of acute coronary syndrome. This study will assess if the increased risk of these patients is modifiable by an anti-platelet medication and evaluate the safety of this medication. Patients will be randomized in an open label fashion to receive ticagrelor (anti-platelet medication) or 81 mg. aspirin. Patients will be followed on study treatment for 12 months, with the last contact at one month post treatment discontinuation.
Study identification
- NCT ID
- NCT02291419
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 6 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2015 (Type not available)
- Primary completion
- Jun 2016 (Actual)
- Completion
- Jun 2016 (Actual)
- Last update posted
- Feb 9, 2017
2015 – 2016
United States locations
- U.S. sites
- 24
- U.S. states
- 15
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama Health System | Mobile | Alabama | 36617 | — |
| Arkansas Site Management Service, LLC | Little Rock | Arkansas | 72211 | — |
| University of Florida College of Medicine - Jacksonville | Jacksonville | Florida | 32209 | — |
| Florida Hospital Orthopaedic Institute and Fracture Care Center | Orlando | Florida | 32804 | — |
| University of South Florida | Tampa | Florida | 33060 | — |
| Central Georgia Heart Center | Macon | Georgia | 31201 | — |
| Saint Vincent Medical Group | Indianapolis | Indiana | 46260 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| McLaren Bay Region | Bay City | Michigan | 48708 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| McLaren Macomb | Mount Clemens | Michigan | 48043 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| New York University School of Medicine | New York | New York | 10016 | — |
| Cincinnati VA Medical Center | Cincinnati | Ohio | 45220 | — |
| VA Medical Center - Cleveland Louis Stokes | Cleveland | Ohio | 44106 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| VA North Texas Health Care System | Dallas | Texas | 75216 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| Overlake Hospital Medical Center | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02291419, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2017 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02291419 live on ClinicalTrials.gov.