ClinicalTrials.gov record
Ublituximab in Combination With Ibrutinib Versus Ibrutinib Alone in Participants With Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL)
ClinicalTrials.gov ID: NCT02301156
Public ClinicalTrials.gov record NCT02301156. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Study to Assess the Efficacy and Safety of Ublituximab in Combination With Ibrutinib Compared to Ibrutinib Alone, in Patients With Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluates the effect of the addition of ublituximab, a novel monoclonal antibody, to ibrutinib compared to ibrutinib alone on antitumor activity, as measured by the overall response rate (ORR = CR \[complete response\] + PR \[partial response\]) in previously treated Chronic Lymphocytic Leukemia (CLL) participants with high-risk cytogenetic features. Half of the participants will receive ublituximab in combination with ibrutinib, while the other half will receive ibrutinib alone.
Study identification
- NCT ID
- NCT02301156
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 126 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2015
- Primary completion
- Mar 31, 2020
- Completion
- Mar 31, 2020
- Last update posted
- May 19, 2022
2015 – 2020
United States locations
- U.S. sites
- 87
- U.S. states
- 34
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| TG Therapeutics Investigational Trial Site | Huntsville | Alabama | 35805 | — |
| TG Therapeutics Investigational Trial Site | Mobile | Alabama | 36604 | — |
| TG Therapeutics Investigational Trial Site | Chandler | Arizona | 85224 | — |
| TG Therapeutics Investigational Trial Site | Tucson | Arizona | 85710 | — |
| TG Therapeutics Investigational Trial Site | Fayetteville | Arkansas | 72703 | — |
| TG Therapeutics Investigational Trial Site | Jonesboro | Arkansas | 72401 | — |
| TG Therapeutics Investigational Trial Site | Fullerton | California | 92835 | — |
| TG Therapeutics Investigational Trial Site | Greenbrae | California | 94904 | — |
| TG Therapeutics Investigational Trial Site | Los Angeles | California | 90045 | — |
| TG Therapeutics Investigational Trial Site | Pismo Beach | California | 93449 | — |
| TG Therapeutics Investigational Trial Site | Pleasanton | California | 94588 | — |
| TG Therapeutics Investigational Trial Site | Santa Barbara | California | 93105 | — |
| TG Therapeutics Investigational Trial Site | Aurora | Colorado | 80012 | — |
| TG Therapeutics Investigational Trial Site | Bridgeport | Connecticut | 06606 | — |
| TG Therapeutics Investigational Trial Site | Stamford | Connecticut | 06904 | — |
| TG Therapeutics Investigational Trial Site | Newark | Delaware | 19173 | — |
| TG Therapeutics Investigational Trial Site | Boca Raton | Florida | 33486 | — |
| TG Therapeutics Investigational Trial Site | Fort Myers | Florida | 33905 | — |
| TG Therapeutics Investigational Trial Site | Orange City | Florida | 32763 | — |
| TG Therapeutics Investigational Trial Site | Pensacola | Florida | 32504 | — |
| TG Therapeutics Investigational Trial Site | St. Petersburg | Florida | 33709 | — |
| TG Therapeutics Investigational Trial Site | West Palm Beach | Florida | 33401 | — |
| TG Therapeutics Investigational Trial Site | Albany | Georgia | 31701 | — |
| TG Therapeutics Investigational Trial Site | Newnan | Georgia | 30265 | — |
| TG Therapeutics Investigational Trial Site | Evanston | Illinois | 60201 | — |
| TG Therapeutics Investigational Trial Site | Maywood | Illinois | 60153 | — |
| TG Therapeutics Investigational Trial Site | Niles | Illinois | 60714 | — |
| TG Therapeutics Investigational Trial Site | Urbana | Illinois | 61801 | — |
| TG Therapeutics Investigational Trial Site | Fort Wayne | Indiana | 46804 | — |
| TG Therapeutics Investigational Trial Site | Indianapolis | Indiana | 46237 | — |
| TG Therapeutics Investigational Trial Site | Ames | Iowa | 50010 | — |
| TG Therapeutics Investigational Trial Site | Cedar Rapids | Iowa | 52403 | — |
| TG Therapeutics Investigational Trial Site | Westwood | Kansas | 66205 | — |
| TG Therapeutics Investigational Trial Site | Baton Rouge | Louisiana | 70816 | — |
| TG Therapeutics Investigational Trial Site | New Orleans | Louisiana | 70121 | — |
| TG Therapeutics Investigational Trial Site | Baltimore | Maryland | 21202 | — |
| TG Therapeutics Investigational Trial Site | Baltimore | Maryland | 21215 | — |
| TG Therapeutics Investigational Trial Site | Bethesda | Maryland | 20817 | — |
| TG Therapeutics Investigational Trial Site | Columbia | Maryland | 21044 | — |
| TG Therapeutics Investigational Trial Site | Salisbury | Maryland | 21801 | — |
| TG Therapeutics Investigational Trial Site | Boston | Massachusetts | 02111 | — |
| TG Therapeutics Investigational Trial Site | Springfield | Massachusetts | 01199 | — |
| TG Therapeutics Investigational Trial Site | Worcester | Massachusetts | 01608 | — |
| TG Therapeutics Investigational Trial Site | Detroit | Michigan | 48202 | — |
| TG Therapeutics Investigational Trial Site | Coon Rapids | Minnesota | 55433 | — |
| TG Therapeutics Investigational Trial Site | Saint Louis Park | Minnesota | 55416 | — |
| TG Therapeutics Investigational Trial Site | Lincoln | Nebraska | 68510 | — |
| TG Therapeutics Investigational Trial Site | Omaha | Nebraska | 68130 | — |
| TG Therapeutics Investigational Trial Site | Lebanon | New Hampshire | 03756 | — |
| TG Therapeutics Investigational Trial Site | East Brunswick | New Jersey | 08816 | — |
| TG Therapeutics Investigational Trial Site | Howell Township | New Jersey | 07731 | — |
| TG Therapeutics Investigational Trial Site | Morristown | New Jersey | 07962 | — |
| TG Therapeutics Investigational Trial Site | Pompton Plains | New Jersey | 07444 | — |
| TG Therapeutics Investigational Trial Site | Somerville | New Jersey | 08876 | — |
| TG Therapeutics Investigational Trial Site | New York | New York | 10019 | — |
| TG Therapeutics Investigational Trial Site | Syracuse | New York | 13210 | — |
| TG Therapeutics Investigational Trial Site | Charlotte | North Carolina | 28204 | — |
| TG Therapeutics Investigational Trial Site | Durham | North Carolina | 27710 | — |
| TG Therapeutics Investigational Trial Site | Raleigh | North Carolina | 27607 | — |
| TG Therapeutics Investigational Trial Site | Canton | Ohio | 44718 | — |
| TG Therapeutics Investigational Trial Site | Cincinnati | Ohio | 45242 | — |
| TG Therapeutics Investigational Trial Site | Cleveland | Ohio | 44106 | — |
| TG Therapeutics Investigational Trial Site | Portland | Oregon | 97213-2982 | — |
| TG Therapeutics Investigational Trial Site | Portland | Oregon | 97227 | — |
| TG Therapeutics Investigational Trial Site | Springfield | Oregon | 97477 | — |
| TG Therapeutics Investigational Trial Site | Camp Hill | Pennsylvania | 17011 | — |
| TG Therapeutics Investigational Trial Site | Philadelphia | Pennsylvania | 19104 | — |
| TG Therapeutics Investigational Trial Site | Pawtucket | Rhode Island | 02860 | — |
| TG Therapeutics Investigational Trial Site | Greenville | South Carolina | 29607 | — |
| TG Therapeutics Investigational Trial Site | Greenville | South Carolina | 29615 | — |
| TG Therapeutics Investigational Trial Site | Sioux Falls | South Dakota | 57105 | — |
| TG Therapeutics Investigational Trial Site | Watertown | South Dakota | 57201 | — |
| TG Therapeutics Investigational Trial Site | Memphis | Tennessee | 38120 | — |
| TG Therapeutics Investigational Trial Site | Nashville | Tennessee | 37203 | — |
| TG Therapeutics Investigational Trial Site | Austin | Texas | 78705 | — |
| TG Therapeutics Investigational Trial Site | Dallas | Texas | 75230 | — |
| TG Therapeutics Investigational Trial Site | Denton | Texas | 76201 | — |
| TG Therapeutics Investigational Trial Site | Fort Sam Houston | Texas | 78234 | — |
| TG Therapeutics Investigational Trial Site | San Antonio | Texas | 78229 | — |
| TG Therapeutics Investigational Trial Site | Tyler | Texas | 75702 | — |
| TG Therapeutics Investigational Trial Site | Webster | Texas | 77598-4420 | — |
| TG Therapeutics Investigational Trial Site | Ogden | Utah | 84403 | — |
| TG Therapeutics Investigational Trial Site | Blacksburg | Virginia | 24060 | — |
| TG Therapeutics Investigational Trial Site | Richmond | Virginia | 23230 | — |
| TG Therapeutics Investigational Trial Site | Seattle | Washington | 98104 | — |
| TG Therapeutics Investigational Trial Site | Spokane | Washington | 99216 | — |
| TG Therapeutics Investigational Trial Site | Vancouver | Washington | 98683 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02301156, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 19, 2022 · Synced Sep 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02301156 live on ClinicalTrials.gov.