12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE Attacks
Public ClinicalTrials.gov record NCT02303626. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
OPuS-2: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Two Dose Levels of BCX4161 for 12 Weeks as an Oral Prophylaxis Treatment for Attacks of Hereditary Angioedema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the safety and efficacy of an oral treatment, BCX4161, in preventing acute attacks in participants with hereditary angioedema (HAE). Eligible participants will be randomized to receive one of two doses of BCX4161 or placebo for 12 weeks. The study will compare the number of acute attacks in each treatment group, as well as a number of other clinical outcomes, and the safety and tolerability of each dose of BCX4161 compared to placebo.
Study identification
- NCT ID
- NCT02303626
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 110 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 17, 2014 (Actual)
- Primary completion
- Jan 2016 (Actual)
- Completion
- Jan 2016 (Actual)
- Last update posted
- Nov 17, 2025
2014 – 2016
United States locations
- U.S. sites
- 25
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Birmingham | Alabama | 35209 | — |
| Not listed | Scottsdale | Arizona | 85251 | — |
| Not listed | Granada Hills | California | 91344 | — |
| Not listed | San Diego | California | 92093 | — |
| Not listed | San Diego | California | 92112 | — |
| Not listed | Walnut Creek | California | 94598 | — |
| Not listed | Colorado Springs | Colorado | 80907 | — |
| Not listed | Shreveport | Louisiana | 71106 | — |
| Not listed | Chevy Chase | Maryland | 20815 | — |
| Not listed | Boston | Massachusetts | 02114 | — |
| Not listed | Plymouth | Minnesota | 55446 | — |
| Not listed | St Louis | Missouri | 63141 | — |
| Not listed | New York | New York | 10029 | — |
| Not listed | Charlotte | North Carolina | 28277 | — |
| Not listed | Cincinnati | Ohio | 45267 | — |
| Not listed | Oklahoma City | Oklahoma | 73131 | — |
| Not listed | Tulsa | Oklahoma | 74133 | — |
| Not listed | Lake Oswego | Oregon | 97035 | — |
| Not listed | Hershey | Pennsylvania | 17033 | — |
| Not listed | Pittsburgh | Pennsylvania | 15241 | — |
| Not listed | Dallas | Texas | 75231 | — |
| Not listed | Galveston | Texas | 77555 | — |
| Not listed | Fairfax | Virginia | 63141 | — |
| Not listed | Spokane | Washington | 99204 | — |
| Not listed | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02303626, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 17, 2025 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02303626 live on ClinicalTrials.gov.