Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
Public ClinicalTrials.gov record NCT02308085. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women With Endocrine Responsive Breast Cancer Who Desire Pregnancy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The best available evidence suggests that pregnancy after breast cancer does not increase a woman's risk of developing a recurrence from her breast cancer. In particular, the most recent data suggest that this is the case also in women with a hormone receptor-positive breast cancer. There is also no indication of increased risk for delivery complications or for the newborn. The aim of the study is to investigate if temporary interruption of endocrine therapy, with the goal to permit pregnancy, is associated with a higher risk of breast cancer recurrence.The study aims also to evaluate different specific indicators related to fertility, pregnancy and breast cancer biology in young women. A psycho-oncological companion study on fertility concerns, psychological well-being and decisional conflicts will be conducted in interested Centers.
Study identification
- NCT ID
- NCT02308085
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 518 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 42 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 3, 2014
- Primary completion
- May 14, 2025
- Completion
- Nov 30, 2028
- Last update posted
- Feb 8, 2026
2014 – 2028
United States locations
- U.S. sites
- 103
- U.S. states
- 30
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars Sinai Medical Centre | Los Angeles | California | 90211 | — |
| Stanford Cancer Institute | Palo Alto | California | 94305 | — |
| Sharp Memorial Hospital | San Diego | California | — | — |
| University of Colorado Cancer Centre - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Center | Boulder | Colorado | 80303 | — |
| SCL Health Saint Joseph Hospital | Denver | Colorado | 80218 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | 06418 | — |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | 06824 | — |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | — |
| Yale University - Yale Cancer Centre | New Haven | Connecticut | 06520 | — |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | 06473 | — |
| Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | 06477 | — |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | 06790 | — |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | — |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | 06708 | — |
| Helen F. Graham Cancer Center | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Medical Oncology Hematology Consultants PA | Newport | Delaware | 19713 | — |
| Regional Hematology Oncology Practice Associates | Newport | Delaware | 19713 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96701 | — |
| OnCare Hawaii Inc - POB I | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Centre | Honolulu | Hawaii | 96813 | — |
| OnCare Hawaii-Kuakini | Honolulu | Hawaii | 96817 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Carle on Vermilion | Danville | Illinois | 61832 | — |
| Carle Physician Group - Effingham | Effingham | Illinois | 62401 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Northwestern University | Evanston | Illinois | 60201 | — |
| NorthShore University Health System - Glenbrook Hospital | Glenview | Illinois | 60026 | — |
| NorthShore Unversity Health System - Highland Park Hospital | Highland Park | Illinois | 60035 | — |
| Mattoon Charleston Primary Care | Mattoon | Illinois | 61938 | — |
| NorthShore Medical Centre | Skokie | Illinois | 60076 | — |
| Carle Cancer Centre | Urbana | Illinois | 61801 | — |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| Greater Baltimore Medical Centre | Baltimore | Maryland | 21204 | — |
| Johns Hopkins University | Baltimore | Maryland | 21218 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215-5450 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48103 | — |
| IHA Hematology Consultants-Brighton | Brighton | Michigan | 48114 | — |
| Saint Joseph Mercy Hospital - Brighton | Brighton | Michigan | 48114 | — |
| IHA Hematology Consultants-Canton | Canton | Michigan | 48188 | — |
| Saint Joseph Mercy Hospital- Canton | Canton | Michigan | 48188 | — |
| IHA Hematology Consultants-Chelsea | Chelsea | Michigan | 48118 | — |
| Saint Joseph Mercy Hospital - Chelsea | Chelsea | Michigan | 48118 | — |
| IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | 48198 | — |
| Sanford Clinic North - Bemidji | Bemidji | Minnesota | 56501 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805-1951 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| St John's Hospital | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital, 800 East 28th Street | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center - Cancer Center | Minneapolis | Minnesota | 55415 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| Park Nicollet Methodist Hospital | Saint Louis Park | Minnesota | 55343 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center | Lebanon | New Hampshire | 03756 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87131 | — |
| Weill Medical College of Cornell University | New York | New York | 10065 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center - Einstein Campus, 1695 Eastchester Road | The Bronx | New York | 10461 | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | — |
| Montefiore Medical Center - Moses Campus, 111 East 210th Street | The Bronx | New York | 10467 | — |
| Dickstein Cancer Treatment Centre | White Plains | New York | 10601 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Southeastern Medical Oncology Centre | Clinton | North Carolina | 28328 | — |
| Southeastern Medical Oncology Centre | Goldsboro | North Carolina | 27534 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | — | — |
| Southeastern Medical Oncology Centre | Jacksonville | North Carolina | 28546 | — |
| Southeastern Medical Oncology Centre | Wilson | North Carolina | 27534 | — |
| Sanford Bismark Medical Centre | Bismarck | North Dakota | 58501 | — |
| Sanford Roger Maris Cancer Centre | Fargo | North Dakota | 58102 | — |
| Sanford Medical Centre | Fargo | North Dakota | 58122 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Chagrin Highlands | Orange | Ohio | 44122 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Women and Infants Hospital of Rhode Island | Providence | Rhode Island | 02905 | — |
| Greenville Health System Cancer Institute-Butternut | Greenville | South Carolina | 29605 | — |
| Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | 29605 | — |
| Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | 29611 | — |
| Greenville Health System Cancer Institute-Greer | Greer | South Carolina | 29650 | — |
| Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | 29672 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | 29307 | — |
| Sanford Cancer Centre Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford USD Medical Centre - Sioux Falls | Sioux Falls | South Dakota | 57104 | — |
| Doctor's Hospital of Laredo | Laredo | Texas | 78045 | — |
| Huntsman Cancer Institute / University of Utah | Salt Lake City | Utah | 84112 | — |
| University of Vermont Medical Centre | Burlington | Vermont | 05401 | — |
| Bon Secours Memorial Regional Medical Centre | Mechanicsville | Virginia | 23116 | — |
| Bon Secours Saint Francis Medical Centre | Midlothian | Virginia | 23114 | — |
| Bon Secours Saint Mary's Hospital | Richmond | Virginia | 23223 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 108 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02308085, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 8, 2026 · Synced Sep 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02308085 live on ClinicalTrials.gov.