Study to Evaluate Switching From a Regimen Consisting of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) Fixed Dose Combination (FDC) to Emtricitabine/Rilpivirine/Tenofovir Alafenamide (FTC/RPV/TAF) FDC in Virologically-Suppressed, HIV-1 Infected Adults
Public ClinicalTrials.gov record NCT02345226. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b, Randomized, Double-Blind Study to Evaluate Switching From a Regimen Consisting of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) Fixed Dose Combination (FDC) to Emtricitabine/Rilpivirine/ Tenofovir Alafenamide (FTC/RPV/TAF) FDC in Virologically-Suppressed, HIV-1 Infected Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to evaluate the non-inferiority of switching to emtricitabine/rilpivirine/tenofovir alafenamide (FTC/RPV/TAF) fixed dose combination (FDC) as compared to continuing the non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen of efavirenz /FTC/tenofovir disoproxil fumarate (EFV/FTC/TDF) FDC in virologically-suppressed HIV-1 infected participants.
Study identification
- NCT ID
- NCT02345226
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 881 participants
Conditions and interventions
Conditions
Interventions
- FTC/RPV/TAF Drug
- EFV/FTC/TDF Placebo Drug
- EFV/FTC/TDF Drug
- FTC/RPV/TAF Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2015 (Actual)
- Primary completion
- Jun 29, 2016 (Actual)
- Completion
- Jan 2, 2019 (Actual)
- Last update posted
- Jan 2, 2020
2015 – 2019
United States locations
- U.S. sites
- 79
- U.S. states
- 24
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Maricopa Integrated Health System | Phoenix | Arizona | 85004 | — |
| Spectrum Medical Group | Phoenix | Arizona | — | — |
| AHF Research Center | Beverly Hills | California | — | — |
| Pacific Oaks Medical Group | Beverly Hills | California | — | — |
| Long Beach Education and Research Consultants | Long Beach | California | — | — |
| Kaiser Permanente | Los Angeles | California | — | — |
| Southern California Men's Medical Group | Los Angeles | California | — | — |
| Tarrant County ID Associates | Los Angeles | California | — | — |
| Kaiser Permanente | Sacramento | California | — | — |
| University of California-UC Davis | Sacramento | California | — | — |
| La Playa Medical Group and Clinical Research | San Diego | California | — | — |
| Kaiser Permanente | San Francisco | California | — | — |
| Optimus Medical | San Francisco | California | — | — |
| Kaiser Permanente | San Leandro | California | — | — |
| Los Angeles BioMedical Institute at Harbor-UCLA Medical Center | Torrance | California | — | — |
| University of Colorado | Aurora | Colorado | — | — |
| Apex Research Institute | Denver | Colorado | — | — |
| Yale University School of Medicine | New Haven | Connecticut | — | — |
| World Health Clinicians' CIRCLE CARE Center | Norwalk | Connecticut | — | — |
| Capital Medical Associates, P.C. | Washington D.C. | District of Columbia | — | — |
| Medical Faculty Associates, Inc. | Washington D.C. | District of Columbia | — | — |
| Whitman Walker Clinic | Washington D.C. | District of Columbia | — | — |
| Gary Richmond, MD, PA, Inc. | Fort Lauderdale | Florida | — | — |
| Therafirst Medical Centers | Fort Lauderdale | Florida | — | — |
| Midway Immunology & Research Center, LLC | Ft. Pierce | Florida | — | — |
| AIDS Healthcare Foundation | Miami | Florida | — | — |
| University of Miami | Miami | Florida | — | — |
| AIDS Healthcare Foundation | Miami Beach | Florida | — | — |
| Orlando Immunology Center | Orlando | Florida | — | — |
| Infectious Diseases Associates of NW Florida, P.A. | Pensacola | Florida | — | — |
| Hillsborough County Health Dept. | Tampa | Florida | — | — |
| Infectious Disease Research Institute Inc. | Tampa | Florida | — | — |
| St. Joseph's Comprehensive Research Institute | Tampa | Florida | — | — |
| AIDS Research & Treatment Center of the Treasure Coast | Vero Beach | Florida | — | — |
| Triple O Research Institute, P.A. | West Palm Beach | Florida | — | — |
| Rowan Tree Medical PA | Wilton Manors | Florida | — | — |
| AIDS Research Consortium of Atlanta | Atlanta | Georgia | — | — |
| Atlanta ID Group | Atlanta | Georgia | — | — |
| Infectious Disease Specialists of Atlanta | Decatur | Georgia | — | — |
| Mercer University School of Medicine | Macon | Georgia | — | — |
| Chatham County Health Department | Savannah | Georgia | — | — |
| The CORE Foundation | Chicago | Illinois | — | — |
| Indiana University Medical Center | Indianapolis | Indiana | — | — |
| Boston University Medical Center | Boston | Massachusetts | — | — |
| Brigham and Women's | Boston | Massachusetts | — | — |
| MetroWest Medical Center | Framingham | Massachusetts | — | — |
| Baystate Infectious Diseases Clinical Research | Springfield | Massachusetts | — | — |
| The Research Institute | Springfield | Massachusetts | — | — |
| Be Well Medical Center | Berkley | Michigan | — | — |
| Henry Ford Health System | Detroit | Michigan | — | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | — | — |
| Southampton Healthcare, Inc. | St Louis | Missouri | — | — |
| Saint Michael's Medical Center | Newark | New Jersey | — | — |
| South Jersey Infectious Disease | Somers Point | New Jersey | — | — |
| Southwest CARE Center | Santa Fe | New Mexico | — | — |
| Upstate Infectious Diseases Associates | Albany | New York | — | — |
| North Shore University Hospital | Manhasset | New York | — | — |
| Columbia University Medical Center/ New York Presbyterian | New York | New York | — | — |
| Jacobi Medical Center | The Bronx | New York | — | — |
| Montefiore Medical Center | The Bronx | New York | — | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | — | — |
| Infectious Disease Consultants, PA | Charlotte | North Carolina | — | — |
| The Brody School of Medicine | Greenville | North Carolina | — | — |
| Rosedale Infectious Diseases | Huntersville | North Carolina | — | — |
| The Ohio State University | Columbus | Ohio | — | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | — | — |
| The Miriam Hospital | Providence | Rhode Island | — | — |
| Medical University of South Carolina | Charleston | South Carolina | — | — |
| Central Texas Clinical Research | Austin | Texas | — | — |
| North Texas Infectious Diseases Consultants | Dallas | Texas | — | — |
| Southwest Infectious Disease Clinical Research, Inc. | Dallas | Texas | — | — |
| Trinity Health and Wellness Center/AIDS Arms, Inc. | Dallas | Texas | — | — |
| AIDS Arms, Inc./Trinity Health & Wellness Center | Fort Worth | Texas | — | — |
| Gordon E. Crofoot, MD, PA | Houston | Texas | — | — |
| Research Access Network | Houston | Texas | — | — |
| DCOL Center for Clinical Research | Longview | Texas | — | — |
| Clinical Alliance for Research & Education - Infectious Diseases, LLC (CARE-ID) | Annandale | Virginia | — | — |
| Peter Shalit, MD | Seattle | Washington | — | — |
| Premier Clinical Research | Spokane | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 38 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02345226, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 2, 2020 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02345226 live on ClinicalTrials.gov.