Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)
Public ClinicalTrials.gov record NCT02345850. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Multi-Center, Phase III Trial of Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301; Progress II)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is designed as a three arm randomized Phase III, multicenter trial comparing two calcineurin inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis to standard tacrolimus and methotrexate (Tac/Mtx) in patients with hematologic malignancies undergoing myeloablative conditioning hematopoietic stem cell transplantation.
Study identification
- NCT ID
- NCT02345850
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 346 participants
Conditions and interventions
Conditions
Interventions
- Unmanipulated Bone Marrow Graft with Tacrolimus/Methotrexate Procedure
- Mobilized CD34-selected Peripheral Blood Stem Cell graft Procedure
- Unmanipulated Bone Marrow Graft with Cyclophosphamide Procedure
- Cyclophosphamide Drug
- Tacrolimus Drug
- Methotrexate Drug
Procedure · Drug
Eligibility (public fields only)
- Age range
- 1 Year to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2015 (Actual)
- Primary completion
- Oct 5, 2020 (Actual)
- Completion
- Oct 5, 2020 (Actual)
- Last update posted
- Mar 7, 2023
2015 – 2020
United States locations
- U.S. sites
- 28
- U.S. states
- 20
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope National Medical Center | Duarte | California | 91010-3000 | — |
| Stanford Hospital and Clinics | Stanford | California | 94305 | — |
| University of Florida College of Medicine | Gainesville | Florida | 32610-0277 | — |
| H. Lee Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Blood & Marrow Transplant Program at Northside Hospital | Atlanta | Georgia | 30342 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Johns Hopkins/SKCCC | Baltimore | Maryland | 21231 | — |
| Dana Farber Cancer Institute/Brigham & Women's Brigham and Women's Hospital | Boston | Massachusetts | 02114 | — |
| Dana Farber Cancer Institute/Massachusetts General Hospital Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Washington University/Barnes Jewish Hospital | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-7680 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Weill Cornell Medical Center/New York Presbyterian | New York | New York | 10065 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| University Hospitals of Cleveland/Case Western | Cleveland | Ohio | 44106-5061 | — |
| Ohio State/Arthur G. James Cancer Hospital | Columbus | Ohio | 43210 | — |
| University of Oklahoma | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Virginia Commonwealth University/MCV Hospitals | Richmond | Virginia | 23298 | — |
| University of Wisconsin Hospital & Clinics | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53211 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02345850, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 7, 2023 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02345850 live on ClinicalTrials.gov.