ClinicalTrials.gov record
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
ClinicalTrials.gov ID: NCT02360215
Public ClinicalTrials.gov record NCT02360215. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site (place where it started) to the brain. Whole brain radiotherapy (WBRT) is the most common treatment for brain metastasis. Unfortunately, the majority of patients with brain metastases experience cognitive (such as learning and memory) deterioration after WBRT. Memantine hydrochloride may enhance cognitive function by binding to and inhibiting channels of receptors located in the central nervous system. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Using radiation techniques, such as intensity modulated radiotherapy to avoid the hippocampal region during WBRT, may reduce the radiation dose to the hippocampus and help limit the radiation-induced cognitive decline. It is not yet known whether giving memantine hydrochloride and WBRT with or without hippocampal avoidance works better in reducing neurocognitive decline in patients with brain metastases.
Study identification
- NCT ID
- NCT02360215
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 518 participants
Conditions and interventions
Interventions
- Whole brain radiation therapy with hippocampal avoidance Radiation
- Memantine Drug
- Whole brain radiation therapy Radiation
Radiation · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2015 (Actual)
- Primary completion
- Apr 30, 2018 (Actual)
- Completion
- Aug 26, 2019 (Actual)
- Last update posted
- Sep 10, 2026
2015 – 2019
United States locations
- U.S. sites
- 212
- U.S. states
- 41
- U.S. cities
- 175
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lewis and Faye Manderson Cancer Center | Tuscaloosa | Alabama | 35401 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | — |
| Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | — |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | — |
| Mercy Cancer Center - Sacramento | Sacramento | California | 95816 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| Stanford Cancer Center South Bay | San Jose | California | 95124 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | 80304 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Saint Vincent's Medical Center | Bridgeport | Connecticut | 06606 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UF Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| Cleveland Clinic-Weston | Weston | Florida | 33331 | — |
| Grady Health System | Atlanta | Georgia | 30303 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho | 83686 | — |
| Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | 83301 | — |
| SIH Cancer Institute | Carterville | Illinois | 62918 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Edward Hines Jr VA Hospital | Hines | Illinois | 60141 | — |
| Condell Memorial Hospital | Libertyville | Illinois | 60048 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| Community Cancer Center East | Indianapolis | Indiana | 46219 | — |
| Community Cancer Center South | Indianapolis | Indiana | 46227 | — |
| Community Cancer Center North | Indianapolis | Indiana | 46256 | — |
| Saint Luke's Hospital | Cedar Rapids | Iowa | 52402 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| MedStar Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | 21044 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| UM Saint Joseph Medical Center | Towson | Maryland | 21204 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Lowell General Hospital | Lowell | Massachusetts | 01854 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | 48183 | — |
| Saint Joseph Mercy Chelsea | Chelsea | Michigan | 48118 | — |
| 21st Century Oncology MHP - Clarkston | Clarkston | Michigan | 48346 | — |
| McLaren Cancer Institute-Clarkston | Clarkston | Michigan | 48346 | — |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | 48038 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| 21st Century Oncology MHP - Farmington | Farmington Hills | Michigan | 48334 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| Mercy Health Mercy Campus | Muskegon | Michigan | 49444 | — |
| McLaren Cancer Institute-Owosso | Owosso | Michigan | 48867 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| McLaren-Port Huron | Port Huron | Michigan | 48060 | — |
| Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | 49085 | — |
| 21st Century Oncology MHP - Troy | Troy | Michigan | 48098 | — |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | — |
| Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota | 56007 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | 56001 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic Radiation Therapy-Northfield | Northfield | Minnesota | 55057 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Community Medical Hospital | Missoula | Montana | 59804 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Wentworth-Douglass Hospital | Dover | New Hampshire | 03820 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| NHRMC Radiation Oncology - 16th Street | Wilmington | North Carolina | 28401 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Cleveland Clinic Cancer Center Independence | Independence | Ohio | 44131 | — |
| UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | 44130 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | 44136 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Crozer-Keystone Regional Cancer Center at Broomall | Broomall | Pennsylvania | 19008 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Crozer Regional Cancer Center at Brinton Lake | Glen Mills | Pennsylvania | 19342 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Aria Health-Torresdale Campus | Philadelphia | Pennsylvania | 19114 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | 29605 | — |
| Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | 29615 | — |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | — |
| The Radiation Oncology Center-Hilton Head/Bluffton | Hilton Head Island | South Carolina | 29926 | — |
| Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | 29307 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0565 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| UTMB Cancer Center at Victory Lakes | League City | Texas | 77573 | — |
| Ogden Regional Medical Center | Ogden | Utah | 84405 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | 05819 | — |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin | 54701 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | 53038 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Community Memorial Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Ascension Columbia Saint Mary's Water Tower Medical Commons | Milwaukee | Wisconsin | 53211 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Zablocki Veterans Administration Medical Center | Milwaukee | Wisconsin | 53295 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | 54482 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
| Diagnostic and Treatment Center | Weston | Wisconsin | 54476 | — |
| Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02360215, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 10, 2026 · Synced Oct 31, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02360215 live on ClinicalTrials.gov.