A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]
Public ClinicalTrials.gov record NCT02367794. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Paclitaxel or Atezolizumab in Combination With Carboplatin+Nab-Paclitaxel Versus Carboplatin+Nab-Paclitaxel in Chemotherapy-Naive Patients With Stage IV Squamous Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, open-label study will evaluate the safety and efficacy of atezolizumab (MPDL3280A) in combination with carboplatin + paclitaxel or carboplatin + nab-paclitaxel compared with treatment with carboplatin + nab-paclitaxel in chemotherapy-naive participants with Stage IV squamous NSCLC.
Study identification
- NCT ID
- NCT02367794
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,021 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (anti-PD-L1) antibody Drug
- Carboplatin Drug
- Nab-Paclitaxel Drug
- Paclitaxel Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 11, 2015 (Actual)
- Primary completion
- Oct 3, 2018 (Actual)
- Completion
- Feb 17, 2021 (Actual)
- Last update posted
- Mar 21, 2022
2015 – 2021
United States locations
- U.S. sites
- 57
- U.S. states
- 28
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Southern CA Permanente Med Grp | Bellflower | California | — | — |
| Kaiser Permanente Oakland Medical Center | Oakland | California | 94611 | — |
| Kaiser Permanente - Sacramento Medical Center and Medical Offices | Sacramento | California | 95825 | — |
| Kaiser Permanente - San Leandro Medical Center | San Leandro | California | 94577 | — |
| Kaiser Permanente - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente; Oncology Clinical Trials | Vallejo | California | 94589 | — |
| Kaiser Permanente - Walnut Creek | Walnut Creek | California | 94596 | — |
| Rocky Mountain Cancer Center | Denver | Colorado | 80218 | — |
| Danbury Hospital | Danbury | Connecticut | 06810 | — |
| Holy Cross Hospital Inc | Fort Lauderdale | Florida | 33308 | — |
| SCRI Florida Cancer Specialists South | Fort Myers | Florida | 33916 | — |
| Florida Cancer Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Hematology Oncology Associates of the Treasure Coast | Port Saint Lucie | Florida | 34952 | — |
| Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building) | St. Petersburg | Florida | 33705 | — |
| University Cancer & Blood Center, LLC; Research | Athens | Georgia | 30607 | — |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Carrollton | Georgia | 30117 | — |
| Central Georgia Cancer Care PC | Macon | Georgia | 31201 | — |
| Southeastern Regional Medical Center, Inc. | Newnan | Georgia | 30265 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Joliet Oncology-Hematology; Associates, Ltd. | Joliet | Illinois | 60435 | — |
| Quincy Medical Group | Quincy | Illinois | 62301 | — |
| Fort Wayne Med Oncology & Hematology Inc | Fort Wayne | Indiana | 46845 | — |
| Hematology-Oncology; Associates of the Quad Cities | Bettendorf | Iowa | 52722 | — |
| Siouxland Hematology/Oncology | Sioux City | Iowa | 51101 | — |
| Lahey Clinic Med Ctr | Lexington | Kentucky | 02421 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Southcoast Health System; Southcoast Centers For Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| St. Joseph Mercy Health System | Ann Arbor | Michigan | 48106 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| St. Luke's Regional Cancer Center | Duluth | Minnesota | 55805 | — |
| Hematology and Oncology Associates at Bridgepoint | Tupelo | Mississippi | 38801 | — |
| Billings Clinic | Billings | Montana | 59102 | — |
| Valley Hospital; Oncology Research | Paramus | New Jersey | 07652 | — |
| Regional Cancer Care Associates LLC | Sewell | New Jersey | 08080 | — |
| Clinical Research Alliance | Westbury | New York | 11590 | — |
| W.G. Bill Hefner VA Medical Center | Salisbury | North Carolina | — | — |
| University of Cincinnati | Cincinnati | Ohio | 45203-0542 | — |
| Mark H. Zangmeister Center | Columbus | Ohio | 43219 | — |
| Oncology Hematology Care, Inc. | Hamilton | Ohio | 45103 | — |
| Oregon Health & Science Uni | Portland | Oregon | 97239 | — |
| St. Luke's Cancer Care Associates | Bethlehem | Pennsylvania | 18015 | — |
| Maryland Oncology Hematology (Lanham) - USOR | Gettysburg | Pennsylvania | 17325 | — |
| Allegheny Cancer Center | Pittsburgh | Pennsylvania | 15212 | — |
| Univ of Pittsburgh Medical Ctr | Pittsburgh | Pennsylvania | 15232 | — |
| SCRI Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | — |
| Tennessee Cancer Specialists | Knoxville | Tennessee | 37920 | — |
| SCRI The Center For Cancer and Blood Disorders | Denton | Texas | 76210 | — |
| Longview Cancer Center | Longview | Texas | 75601 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Providence Regional Cancer Partnership | Everett | Washington | 98201 | — |
| Medical Oncology Associates | Spokane | Washington | 99208 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 185 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02367794, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 21, 2022 · Synced Nov 3, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02367794 live on ClinicalTrials.gov.