Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission
Public ClinicalTrials.gov record NCT02373813. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Withdrawal Double-blind Study of Etanercept Monotherapy Compared to Methotrexate Monotherapy for Maintenance of Remission in Subjects With Rheumatoid Arthritis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of etanercept monotherapy compared to methotrexate monotherapy on maintenance of remission in participants with rheumatoid arthritis (RA) who were on etanercept plus methotrexate therapy. This is a multicenter, randomized withdrawal, double-blind controlled study in participants with rheumatoid arthritis on etanercept plus methotrexate therapy who are in very good disease control for 6 months prior to study entry. The study will consist of a 30-day screening period, a 24-week open label run-in period, a 48-week double-blind treatment period and a 30-day safety follow-up period.
Study identification
- NCT ID
- NCT02373813
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 371 participants
Conditions and interventions
Conditions
Interventions
- etanercept pre-filled syringe subcutaneous injection Drug
- Oral methotrexate Drug
- Placebo for etanercept subcutaneous injection Drug
- Placebo for methotrexate Drug
- Folic acid (non-investigational product) Dietary Supplement
Drug · Dietary Supplement
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 20, 2015 (Actual)
- Primary completion
- Dec 6, 2019 (Actual)
- Completion
- Dec 6, 2019 (Actual)
- Last update posted
- Jan 11, 2023
2015 – 2019
United States locations
- U.S. sites
- 74
- U.S. states
- 22
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Birmingham | Alabama | 35294 | — |
| Research Site | Huntsville | Alabama | 35801 | — |
| Research Site | Glendale | Arizona | 85306 | — |
| Research Site | Mesa | Arizona | 85202 | — |
| Research Site | Phoenix | Arizona | 85037 | — |
| Research Site | Scottsdale | Arizona | 85258 | — |
| Research Site | Escondido | California | 92025 | — |
| Research Site | Fontana | California | 92335 | — |
| Research Site | Hemet | California | 92543 | — |
| Research Site | Huntington Beach | California | 92646 | — |
| Research Site | La Jolla | California | 92037 | — |
| Research Site | Murrieta | California | 92563 | — |
| Research Site | Orange | California | 92868 | — |
| Research Site | Sacramento | California | 95817 | — |
| Research Site | Santa Maria | California | 93454-6945 | — |
| Research Site | Torrance | California | 90502 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | Victorville | California | 92395 | — |
| Research Site | West Hills | California | 91307 | — |
| Research Site | Doral | Florida | 33126 | — |
| Research Site | Fort Lauderdale | Florida | 33309 | — |
| Research Site | Gainesville | Florida | 32607 | — |
| Research Site | Miami | Florida | 33126 | — |
| Research Site | Miami | Florida | 33144 | — |
| Research Site | Orlando | Florida | 32806 | — |
| Research Site | Palm Harbor | Florida | 34684 | — |
| Research Site | Pensacola | Florida | 32514 | — |
| Research Site | St. Petersburg | Florida | 33705 | — |
| Research Site | Tampa | Florida | 33613 | — |
| Research Site | Lawrenceville | Georgia | 30046 | — |
| Research Site | Boise | Idaho | 83702 | — |
| Research Site | Meridian | Idaho | 83642 | — |
| Research Site | Blue Island | Illinois | 60406 | — |
| Research Site | Skokie | Illinois | 60076 | — |
| Research Site | Springfield | Illinois | 62703 | — |
| Research Site | Granger | Indiana | 46530 | — |
| Research Site | Baton Rouge | Louisiana | 70809 | — |
| Research Site | New Orleans | Louisiana | 70121 | — |
| Research Site | Wheaton | Maryland | 20902 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Grand Rapids | Michigan | 49546 | — |
| Research Site | Kalamazoo | Michigan | 49008 | — |
| Research Site | Lansing | Michigan | 48910 | — |
| Research Site | Lansing | Michigan | 48917 | — |
| Research Site | Springfield | Missouri | 65807 | — |
| Research Site | St Louis | Missouri | 63141 | — |
| Research Site | Clifton | New Jersey | 07012 | — |
| Research Site | Freehold | New Jersey | 07728 | — |
| Research Site | Newark | New Jersey | 07103 | — |
| Research Site | Albuquerque | New Mexico | 87102 | — |
| Research Site | Brooklyn | New York | 11201 | — |
| Research Site | Great Neck | New York | 11021 | — |
| Research Site | New York | New York | 10021 | — |
| Research Site | Charlotte | North Carolina | 28204 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Oklahoma City | Oklahoma | 73103 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Pittsburgh | Pennsylvania | 15224 | — |
| Research Site | Wynnewood | Pennsylvania | 19096 | — |
| Research Site | Wyomissing | Pennsylvania | 19610 | — |
| Research Site | Charleston | South Carolina | 29406 | — |
| Research Site | Orangeburg | South Carolina | 29118 | — |
| Research Site | Jackson | Tennessee | 38305 | — |
| Research Site | Knoxville | Tennessee | 37909-1900 | — |
| Research Site | Carrollton | Texas | 75007 | — |
| Research Site | Corpus Christi | Texas | 78404 | — |
| Research Site | Cypress | Texas | 77429 | — |
| Research Site | League City | Texas | 77573 | — |
| Research Site | Plano | Texas | 75024 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Webster | Texas | 77598 | — |
| Research Site | Danville | Virginia | 24541 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02373813, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 11, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02373813 live on ClinicalTrials.gov.