Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function
Public ClinicalTrials.gov record NCT02408900. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pilot Study of Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background: \- Primary lateral sclerosis (PLS) is a rare disease. It leads to weakness in the muscle of the arms, legs, and face. People with PLS develop muscle stiffness called spasticity. Researchers want to find a better way to measure this. They want to see if ultrasound, which uses sound waves to look at parts of the body, can measure spasticity and stiffness in muscles. Objective: \- To see if ultrasound can detect and measure muscle spasticity in people with PLS. Eligibility: * People ages 18 75 who have a diagnosis of PLS and are enrolled in protocol 01-N-0145. * Healthy volunteers ages 18 75. Design: * Participants with PLS will have 1 study visit. Healthy participants will have upto 5 visits. Each visit will be about 2 hours. * Participants will have tests of muscle strength. They will be examined. They will push their arms and legs against researchers in different positions. * Participants will have tests of muscle stiffness. Their arms and legs will be moved while they relax. * Participants will have a muscle ultrasound test. They will lie on a table. Gel will be placed on the skin over the muscles of the arms and legs. A probe, like a microphone, will be moved over the skin. Researchers will look at several muscles. * Participants should try to stay still during the ultrasound. It may be done several times and may be done by different examiners.
Study identification
- NCT ID
- NCT02408900
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 15 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 24, 2015
- Primary completion
- Aug 2, 2015
- Completion
- Aug 2, 2015
- Last update posted
- Dec 16, 2019
2015
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland | 20892 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02408900, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 16, 2019 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02408900 live on ClinicalTrials.gov.