ClinicalTrials.gov record
Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer
ClinicalTrials.gov ID: NCT02412670
Public ClinicalTrials.gov record NCT02412670. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective Phase II Trial of Neoadjuvant Systemic Chemotherapy Followed by Extirpative Surgery for Patients With High Grade Upper Tract Urothelial Carcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II trial studies how well giving chemotherapy before surgery works in treating patients with aggressive upper urinary tract cancer. Drugs used in chemotherapy, such as methotrexate, vinblastine, doxorubicin hydrochloride, cisplatin, gemcitabine hydrochloride, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Removing the affected upper urinary tract by surgery is the recommended treatment for upper urinary tract cancer, but can cause loss of kidney function and prevent patients from being able to receive chemotherapy after surgery. Giving chemotherapy before surgery, when the kidneys are working at their maximum, may allow less tissue to be removed during surgery and may be more effective in treating patients with high grade upper urinary tract cancer.
Study identification
- NCT ID
- NCT02412670
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 36 participants
Conditions and interventions
Conditions
Interventions
- Methotrexate Drug
- Vinblastine Drug
- Doxorubicin Drug
- Cisplatin Drug
- Gemcitabine Drug
- Carboplatin Drug
- Pegfilgrastim Drug
- Nephroureterectomy Procedure
Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 27, 2015 (Actual)
- Primary completion
- Aug 23, 2018 (Actual)
- Completion
- May 10, 2022 (Actual)
- Last update posted
- Jul 10, 2023
2015 – 2022
United States locations
- U.S. sites
- 134
- U.S. states
- 19
- U.S. cities
- 96
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Memorial Hospital Colorado Springs | Colorado Springs | Colorado | 80909 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Christiana Gynecologic Oncology LLC | Newark | Delaware | 19713 | — |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Regional Hematology and Oncology PA | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| Nanticoke Memorial Hospital | Seaford | Delaware | 19973 | — |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Low Country Cancer Care Associates PC | Savannah | Georgia | 31405 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | — |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | — |
| Memorial Hospital of Carbondale | Carbondale | Illinois | 62902 | — |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| Carle on Vermilion | Danville | Illinois | 61832 | — |
| Cancer Care Center of Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | — |
| Illinois CancerCare Galesburg | Galesburg | Illinois | 61401 | — |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Radiation Oncology of Northern Illinois | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | — |
| Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC | Peoria | Illinois | 61615-7827 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | — |
| Valley Radiation Oncology | Peru | Illinois | 61354 | — |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | — |
| Central Illinois Hematology Oncology Center | Springfield | Illinois | 62702 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois | 62226 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | 46360 | — |
| Woodland Cancer Care Center | Michigan City | Indiana | 46360 | — |
| Reid Hospital and Health Care Services | Richmond | Indiana | 47374 | — |
| Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | 41017 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Oakwood Hospital and Medical Center | Dearborn | Michigan | 48124 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| Saint Joseph Mercy Port Huron | Port Huron | Michigan | 48060 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Central Care Cancer Center-Carrie J Babb Cancer Center | Bolivar | Missouri | 65613 | — |
| Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | 63628 | — |
| CoxHealth Cancer Center | Branson | Missouri | 65616 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| Capital Region Medical Center-Goldschmidt Cancer Center | Jefferson City | Missouri | 65109 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Mercy Hospital-Joplin | Joplin | Missouri | 64804 | — |
| Phelps County Regional Medical Center | Rolla | Missouri | 65401 | — |
| Saint John's Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | 45202 | — |
| Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | 45211 | — |
| Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio | 45230 | — |
| Oncology Hematology Care Inc - Kenwood | Cincinnati | Ohio | 45236 | — |
| Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | 45242 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Health Center | Dayton | Ohio | 45415 | — |
| Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | 45014 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Springfield Regional Cancer Center | Springfield | Ohio | 45504 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| Flower Hospital | Sylvania | Ohio | 43560 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Tulsa Cancer Institute | Tulsa | Oklahoma | 74146 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | 18201 | — |
| Geisinger Medical Oncology at Evangelical Community Hospital | Lewisburg | Pennsylvania | 17837 | — |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | — |
| ECOG-ACRIN Cancer Research Group | Philadelphia | Pennsylvania | 19103 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Geisinger Medical Oncology-Pottsville | Pottsville | Pennsylvania | 17901 | — |
| Geisinger Medical Group | State College | Pennsylvania | 16801 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | 37067 | — |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| Aurora Cancer Care-Burlington | Burlington | Wisconsin | 53105 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin | 54143 | — |
| Aurora Advanced Healthcare Inc-Menomonee Falls | Menomonee Falls | Wisconsin | 53051 | — |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406-5661 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Aurora Cancer Care-Waukesha | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02412670, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 10, 2023 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02412670 live on ClinicalTrials.gov.