The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma
Public ClinicalTrials.gov record NCT02414165. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Randomized, Open-Label Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC Versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma
Study identification
- NCT ID
- NCT02414165
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Tocagen Inc.
- Industry
- Enrollment
- 403 participants
Conditions and interventions
Conditions
Interventions
- Toca 511 Biological
- Toca FC Drug
- Lomustine Drug
- Temozolomide Drug
- Bevacizumab Biological
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 29, 2015
- Primary completion
- May 30, 2019
- Completion
- Dec 19, 2019
- Last update posted
- Feb 6, 2020
2015 – 2019
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurological Institute at Dignity Health St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| University of California, Irvine | Irvine | California | 92868 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| University of California, Los Angeles | Los Angeles | California | 90095 | — |
| St. Joseph Hospital | Orange | California | 92868 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | — |
| Colorado Neurological Institute | Englewood | Colorado | 80113 | — |
| Associated Neurologists of Southern Connecticut | Fairfield | Connecticut | 06824 | — |
| Yale University/Yale Cancer Center | New Haven | Connecticut | 06520 | — |
| University of Florida McKnight Brain Institute | Gainesville | Florida | 32611 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Abbott Northwestern Hospital / Allina Health | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| HCA Midwest / Sarah Cannon | Kansas City | Missouri | 64132 | — |
| Washington University St. Louis | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| JFK Medical Center Neuroscience Institute | Edison | New Jersey | 08820 | — |
| John Theurer Cancer Center at Hackensack University | Hackensack | New Jersey | 07601 | — |
| Overlook Medical Center | Summit | New Jersey | 07901 | — |
| North Shore University Hospital | Lake Success | New York | 11042 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Columbia University | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Cincinnati's Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19101 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Sanford Research | Sioux Falls | South Dakota | 57104 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Houston Methodist Hospital Outpatient Center | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston (UTHealth) | Houston | Texas | 77030 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Inova Dwight and Martha Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Sentara Neurosurgery Specialists | Norfolk | Virginia | 23507 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02414165, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 6, 2020 · Synced Jun 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02414165 live on ClinicalTrials.gov.