Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)
Public ClinicalTrials.gov record NCT02414958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomised, Double Blind, Placebo-controlled, Parallel Group, Efficacy, Safety and Tolerability Trial of Once Daily, Oral Doses of Empagliflozin as Adjunctive to inSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Comparison of 2 doses of empagliflozin vs placebo in patients already using either an insulin regimen of multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). Randomisation to 3 treatments arms (equal assignment) following a screening period, an optimisation period and a run-in period. 52 week double-blind treatment period, and 3 week follow-up period.
Study identification
- NCT ID
- NCT02414958
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 730 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2015 (Actual)
- Primary completion
- Apr 20, 2017 (Actual)
- Completion
- Oct 23, 2017 (Actual)
- Last update posted
- Jan 3, 2019
2015 – 2017
United States locations
- U.S. sites
- 34
- U.S. states
- 17
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMCR Institute, Inc. | Escondido | California | 92025 | — |
| Diabetes/Lipid Management and Research Center | Huntington Beach | California | 92648 | — |
| National Research Institute | Los Angeles | California | 90057 | — |
| Mills-Peninsula Health Services | San Mateo | California | 94401 | — |
| Metabolic Institute of America | Tarzana | California | 91356 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| Creekside Endocrine Associates, PC | Denver | Colorado | 80246 | — |
| The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32204 | — |
| Baptist Diabetes Associates, PA | Miami | Florida | 33156 | — |
| Physicians Research Associates, LLC | Lawrenceville | Georgia | 30046 | — |
| Endocrine Research Solutions, Inc. | Roswell | Georgia | 30076 | — |
| Rocky Mountain Diabetes and Osteoporosis Center | Idaho Falls | Idaho | 83404 | — |
| Northwest Endo Diabetes Research, LLC | Arlington Heights | Illinois | 60005 | — |
| Midwest Endocrinology | Crystal Lake | Illinois | 60012 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Diabetes anddocrine Associates, PC | Omaha | Nebraska | 68114 | — |
| Desert Endocrinology Clinical Research Center | Henderson | Nevada | 89052 | — |
| Palm Research Center | Las Vegas | Nevada | 89148 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03063 | — |
| Albany Medical Center / Albany Medical College | Albany | New York | 12206 | — |
| University Physicians Group Research Division | Staten Island | New York | 10301 | — |
| Diabetes and Endocrinology Consultants, PC | Morehead City | North Carolina | 28557 | — |
| The Carl and Edyth Lindner Center for Research & Education at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Diabetes and Obesity Clinical Trials Center | Nashville | Tennessee | 37212 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Office of Dr. Michelle Zaniewski-Singh | Houston | Texas | 77090 | — |
| Texas Diabetes and Endocrinology | Round Rock | Texas | 78681 | — |
| Bateman Horne Center | Salt Lake City | Utah | 84102 | — |
| Advanced Research Institute | South Ogden | Utah | 84405 | — |
| Larry D Stonesifer, MD Inc., PS | Federal Way | Washington | 98003 | — |
| Rainier Clinical Research Center, Inc | Renton | Washington | 98057 | — |
| The Polyclinic | Seattle | Washington | 98104 | — |
| MultiCare Institute for Research and Innovation | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 97 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02414958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 3, 2019 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02414958 live on ClinicalTrials.gov.