ClinicalTrials.gov record
A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart
ClinicalTrials.gov ID: NCT02415400
Public ClinicalTrials.gov record NCT02415400. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients With Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine if Apixaban is safer than a Vitamin K Antagonist given for 6 months in terms of bleeding in patients with an irregular heart beat (atrial fibrillation) and a recent heart attack or a recent procedure to open up a blood vessel in the heart. All patients would also be taking a class of medicines called P2Y12 inhibitors (such as clopidogrel/Plavix) and be treated for up to 6 months. The primary focus will be a comparison of the bleeding risk of Apixaban, with or without aspirin, versus a Vitamin K antagonist, such as warfarin, with or without aspirin.
Study identification
- NCT ID
- NCT02415400
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 4,614 participants
Conditions and interventions
Conditions
Interventions
- Apixaban Drug
- vitamin K antagonist Drug
- Acetylsalicylic acid Drug
- Acetylsalicylic acid placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 95 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 4, 2015 (Actual)
- Primary completion
- Nov 10, 2018 (Actual)
- Completion
- Nov 10, 2018 (Actual)
- Last update posted
- Jun 11, 2020
2015 – 2018
United States locations
- U.S. sites
- 143
- U.S. states
- 38
- U.S. cities
- 128
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiovascular Associates of the Southeast, LLC | Birmingham | Alabama | 35243 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3410 | — |
| Arizona Heart Rhythm Center | Phoenix | Arizona | 85013 | — |
| Local Institution | Phoenix | Arizona | 85054 | — |
| Scottsdale Osborn Medical Center | Scottsdale | Arizona | 85251 | — |
| Southern Arizona VA Health Care System | Tucson | Arizona | 85723 | — |
| Local Institution | Little Rock | Arkansas | 72204 | — |
| Local Institution | Phoenix | Arkansas | 85015 | — |
| Comprehensive Cardiovascular Specialists | Alhambra | California | 91801 | — |
| Local Institution | Culver City | California | 90230 | — |
| Washington Township Medical Foundation | Fremont | California | 94536 | — |
| California Heart Specialist, Inc. | Huntington Beach | California | 92648 | — |
| Foundation For Cardiovascular Medicine | La Jolla | California | 92037 | — |
| Local Institution | Long Beach | California | 90806 | — |
| Local Institution | Rancho Mirage | California | 92270 | — |
| Local Institution | San Diego | California | 92161 | — |
| Manshadi Heart Institute | Stockton | California | 95204 | — |
| Local Institution | Torrance | California | 90502 | — |
| University Of Colorado | Aurora | Colorado | 80045 | — |
| Colorado Heart and Vascular | Lakewood | Colorado | 80228 | — |
| Local Institution | Norwalk | Connecticut | 06851 | — |
| Local Institution | Wilmington | Delaware | 19803 | — |
| Orlando Heart Specialists | Altamonte Springs | Florida | 32714 | — |
| Local Institution | Bradenton | Florida | 34209 | — |
| Clearwater Cardiovascular and Interventional Consultants | Clearwater | Florida | 33756 | — |
| Local Institution | Clearwater | Florida | 33756 | — |
| Daytona Heart Group | Daytona Beach | Florida | 32114 | — |
| Local Institution | Fort Lauderdale | Florida | 33316 | — |
| Local Institution | Jacksonville | Florida | 32204 | — |
| Local Institution | Jacksonville | Florida | 32216 | — |
| Local Institution | Jacksonville Beach | Florida | 32250 | — |
| Tenet Florida Physician Services | Jupiter | Florida | 33458 | — |
| Local Institution | Lake Mary | Florida | 32746 | — |
| Local Institution | Miami | Florida | 33173 | — |
| Mediquest Research | Ocala | Florida | 34471 | — |
| Local Institution | Orlando | Florida | 32825 | — |
| CP Cardiology Partners | Palm Beach Gardens | Florida | 33410 | — |
| Bayfront Health St. Petersburg | St. Petersburg | Florida | 33701 | — |
| Local Institution | Tampa | Florida | 33613 | — |
| Cardiology Partners | Wellington | Florida | 33449 | — |
| Athens Regional Cariology Group | Athens | Georgia | 30606 | — |
| Local Institution | Atlanta | Georgia | 30342 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Georgia Heart Specialists | Covington | Georgia | 30014 | — |
| Local Institution | Cumming | Georgia | 30041 | — |
| Local Institution | Tucker | Georgia | 30084 | — |
| Saint Lukes Idaho Cardiology Associates | Boise | Idaho | 83712 | — |
| Medicoricium, LLC | Fairview Heights | Illinois | 62208 | — |
| Gateway Cardiology PC | Jerseyville | Illinois | 62052 | — |
| Advocate Medical Group ? Cardiology and Pulmonology | Normal | Illinois | 61761 | — |
| South Suburban Cardiology | Olympia Fields | Illinois | 60461 | — |
| Local Institution | Bloomington | Indiana | 47403 | — |
| Elkhart Clinic LLC | Elkhart | Indiana | 46514 | — |
| Roudebush VA Medical Center | Indianapolis | Indiana | 46202 | — |
| Reid Hospital and Health Care Services | Richmond | Indiana | 47374 | — |
| Midwest Cardiovascular Research Foundation | Davenport | Iowa | 52803 | — |
| University of Iowa Stead Family Children's Hospital | Iowa City | Iowa | 52242 | — |
| Northeast Iowa Family Practice Center | Waterloo | Iowa | 50702 | — |
| Local Institution | Kansas City | Kansas | 66160 | — |
| Local Institution | Wichita | Kansas | 67203 | — |
| Saint Elizabeth Healthcare | Crestview Hills | Kentucky | 41017 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Alexandria Cardiology Clinic | Alexandria | Louisiana | 71301 | — |
| Imperial Health | Lake Charles | Louisiana | 70601 | — |
| Local Institution | Minden | Louisiana | 71055 | — |
| Clinical Trials of America LA LLC - PPDS | Monroe | Louisiana | 71201 | — |
| Local Institution | Natick | Massachusetts | 01760 | — |
| Great Lakes Heart Center of Alpena | Alpena | Michigan | 49707 | — |
| Local Institution | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Local Institution | Detroit | Michigan | 48202 | — |
| Local Institution | Lansing | Michigan | 48912 | — |
| Covenant Center for the Heart | Saginaw | Michigan | 48602 | — |
| Metropolitan Cardiology Consultants | Minneapolis | Minnesota | 55433-4568 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Local Institution | Jackson | Mississippi | 39216 | — |
| Cardiology Associates Research LLC | Tupelo | Mississippi | 38801 | — |
| Missouri Cardiovascular Specialists | Columbia | Missouri | 65201 | — |
| Local Institution | Columbia | Missouri | 65212 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Cox Health Systems | Springfield | Missouri | 65807 | — |
| Gateway Cardiology PC | St Louis | Missouri | 63128 | — |
| St. Louis Heart and Vascular | St Louis | Missouri | 63136 | — |
| Local Institution | Billings | Montana | 59101 | — |
| Bryan Heart Hospital | Lincoln | Nebraska | 68506 | — |
| HCP Clinical Research LLC | Las Vegas | Nevada | 89169 | — |
| Renown Regional Medical Center. | Reno | Nevada | 89502 | — |
| New Jersey Heart | Linden | New Jersey | 07036 | — |
| Capital Cardiology Associates | Albany | New York | 12211 | — |
| New York-Presbyterian Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Local Institution | Brooklyn | New York | 11217 | — |
| Buffalo Heart Group LLP | Buffalo | New York | 14215 | — |
| Mount Sinai-St. Lukes | New York | New York | 10025 | — |
| Hudson Valley Cardiovascular Practice, PC | Poughkeepsie | New York | 12601 | — |
| Asheville Cardiology Associates PA | Asheville | North Carolina | 28801 | — |
| University of North Carolina School of Medicine | Chapel Hill | North Carolina | 27599 | — |
| Durham VA Medical Center | Durham | North Carolina | 27705 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Clinical Trials of America-NC, LLC - PPDS | Lenoir | North Carolina | 28645 | — |
| Duke Cardiology and Cardiovascular Surgery of Lumberton | Lumberton | North Carolina | 28358 | — |
| PMG Research of Wilmington | Wilmington | North Carolina | 28401 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Local Institution | Columbus | Ohio | 43214 | — |
| Local Institution | Kettering | Ohio | 45429 | — |
| Local Institution | Willoughby | Ohio | 44094 | — |
| Saint Vincent Hospital | Erie | Pennsylvania | 16544 | — |
| Heart Group | Lancaster | Pennsylvania | 17603 | — |
| Mercer Bucks Cardiology | Newton | Pennsylvania | 18940 | — |
| WellSpan York Hospital | York | Pennsylvania | 17405 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Columbia Heart | Columbia | South Carolina | 29204 | — |
| Upstate Cardiology PA | Greenville | South Carolina | 29607 | — |
| Roper St. Francis Healthcare | North Charleston | South Carolina | 29418 | — |
| Carolina Cardiology Clinical Research Institute | Rock Hill | South Carolina | 29732 | — |
| Local Institution | Germantown | Tennessee | 38138 | — |
| Research Associates of Jackson | Jackson | Tennessee | 38301 | — |
| Cardiovascular Research of Knoxville | Knoxville | Tennessee | 37917 | — |
| Knoxville Health Managment Associates Cardiology PPM LLC | Knoxville | Tennessee | 37934 | — |
| Parkway Cardiology Associates PC | Oak Ridge | Tennessee | 37830 | — |
| Local Institution | Austin | Texas | 78705 | — |
| Local Institution | Austin | Texas | 78758 | — |
| Local Institution | Dallas | Texas | 75216 | — |
| San Antonio Military Medical Center | Fort Sam Houston | Texas | 78234 | — |
| Angiocardiac Care of Texas PA | Houston | Texas | 77025 | — |
| Local Institution | Houston | Texas | 77084 | — |
| Local Institution | Houston | Texas | 77089 | — |
| Grace Research, LLC | Huntsville | Texas | 77340 | — |
| Local Institution | Huntsville | Texas | 77340 | — |
| Local Institution | Katy | Texas | 77450 | — |
| Caprock Cardiac Center Research Institute | Lubbock | Texas | 79410 | — |
| Local Institution | Plano | Texas | 75024 | — |
| Local Institution | San Antonio | Texas | 78229 | — |
| Mercury Medical LLC | San Antonio | Texas | 78229 | — |
| Local Institution | Sealy | Texas | 77474 | — |
| Local Institution | Sugar Land | Texas | 77479 | — |
| Victoria Heart and Vascular Center | Victoria | Texas | 77901 | — |
| University of Vermont | Burlington | Vermont | 05403 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Virginia Heart Group Ltd | Leesburg | Virginia | 20176 | — |
| CJW Medical Center | Richmond | Virginia | 23235 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| St Mary's Medical Center | Huntington | West Virginia | 25702 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 483 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02415400, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 11, 2020 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02415400 live on ClinicalTrials.gov.