A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)
Public ClinicalTrials.gov record NCT02425891. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Placebo-Controlled Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Patients With Previously Untreated Metastatic Triple-Negative Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This multicenter, randomized, double-blind study evaluated the efficacy, safety, and pharmacokinetics of atezolizumab (MPDL3280A) administered with nab-paclitaxel compared with placebo in combination with nab-paclitaxel in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic breast cancer (mBC). The safety of single-agent nab-paclitaxel has been determined in previous studies of participants with mBC and the safety data to date suggest that atezolizumab can be safely combined with standard chemotherapy agents.
Study identification
- NCT ID
- NCT02425891
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 902 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 23, 2015 (Actual)
- Primary completion
- Apr 14, 2020 (Actual)
- Completion
- Aug 31, 2021 (Actual)
- Last update posted
- Jul 19, 2022
2015 – 2021
United States locations
- U.S. sites
- 49
- U.S. states
- 24
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Kaiser Permanente of Northern California | Oakland | California | 94612 | — |
| Emad Ibrahim, Md, Inc | Redlands | California | 92373 | — |
| Univ of Calif, San Francisco; Breast Cancer Center | San Francisco | California | 94115 | — |
| Kaiser Permanente - San Marcos | San Marcos | California | 92069 | — |
| Cancer Research Collaboration, Inc. | Santa Ana | California | 92705 | — |
| Stanford Univ School of Med; Oncology | Stanford | California | 94305-5821 | — |
| Kaiser Permanente Of Colorado | Aurora | Colorado | 80014 | — |
| Yale Cancer Center; Medical Oncology | New Haven | Connecticut | 06520 | — |
| Norwalk Hospital | Norwalk | Connecticut | 06856 | — |
| Stamford Hospital; BCC, MOHR | Stamford | Connecticut | 06904 | — |
| MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center) | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists - SCRI; Pharmacy | Fort Myers | Florida | 33901 | — |
| Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) | Jacksonville | Florida | 32256 | — |
| The Mount Siani Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Florida Cancer Research Institute | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building) | St. Petersburg | Florida | 33705 | — |
| Northwest Georgia Oncology Centers PC - Marietta | Marietta | Georgia | 30060 | — |
| Rush University Medical Center - Chicago | Chicago | Illinois | 60612 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Johns Hopkins Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21287 | — |
| Maryland Oncology Hematology | Rochville | Maryland | 20850 | — |
| Barbara Ann Karmanos Cancer Institute; Oncology | Detroit | Michigan | 48201 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Jackson Oncology Associates, PLLC | Jackson | Mississippi | 39202 | — |
| Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC | Kansas City | Missouri | 64132 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| New Hampshire Hematology Oncology | Manchester | New Hampshire | 03103 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| ProHEALTH Care Associates LLP | Lake Success | New York | 11042 | — |
| Laura and ISAAC Perlmutter Cancer Center at NYU Langone. | New York | New York | 10016 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Onc/Hem Care Clin Trials LLC | Cincinnati | Ohio | 45242 | — |
| The Mark H. Zangmeister Ctr; Mid Ohio Onc/Hem Inc. | Columbus | Ohio | 43219 | — |
| Kaiser Perm NW - Rheuma | Portland | Oregon | 97227 | — |
| Providence Cancer Center | Portland | Oregon | 97231 | — |
| St. Luke's Cancer Care Associates | Bethlehem | Pennsylvania | 18015 | — |
| Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Greenville Health System (GHS) Cancer Institute | Greenville | South Carolina | 29605 | — |
| Wellmont Bristol Regional Medical Center | Bristol | Tennessee | 37620 | — |
| West Clinic | Germantown | Tennessee | 38138 | — |
| Sarah Cannon Cancer Center - Tennessee Oncology, Pllc | Nashville | Tennessee | 37203 | — |
| Vanderbilt | Nashville | Tennessee | 37232 | — |
| Texas Oncology- El Paso Cancer Treatment Center Gateway | El Paso | Texas | 79915 | — |
| The Methodist Cancer Center | Houston | Texas | 77030 | — |
| University of Texas;M.D. Anderson Cancer Center | Houston | Texas | 77030 | — |
| Inova Medical Group | Fairfax | Virginia | 22031 | — |
| Cancer Care Northwest | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 198 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02425891, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 19, 2022 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02425891 live on ClinicalTrials.gov.